公开(公告)号：US5775339A

公开(公告)日：1998-07-07

申请号：US914272

申请日：1997-08-19

申请人： Kathryn W. Woodburn ,  Qing Fan ,  Stuart W. Young

发明人： Kathryn W. Woodburn ,  Qing Fan ,  Stuart W. Young

IPC分类号： A61K31/407 ,  A61K41/00 ,  A61B19/00

CPC分类号： A61K31/407 ,  A61K41/0033 ,  A61K41/0076 ,  Y10S607/901

摘要： The present invention involves the use of a photosensitive texaphyrin for the photodynamic treatment of a pigmented lesion, such as a melanodermic lesion, or a lesion obscured by pigmented tissue such as melaniferous tissue in a subject. In particular, the invention provides a treatment for the metastatic process of melanoma, and a method for inhibiting growth of established metastases of melanoma. The photosensitive texaphyrin may be a free-base texaphyrin or may be metallated with a diamagnetic metal. Preferably, the texaphyrin is metallated with lutetium. Heretofore, melanoma has been refractory to treatment with photodynamic therapy.

摘要翻译： 本发明涉及使用感光性泰克萨菲瑞用于色素沉着病变如黑素瘤病变的光动力学治疗或被受试者中着色组织如黑色素组织遮盖的病变。 特别地，本发明提供了黑素瘤的转移过程的治疗方法，以及抑制已有的黑色素瘤转移的生长的方法。 感光性泰克萨菲瑞可以是游离碱泰克萨菲瑞，也可以用抗磁性金属进行金属化。 泰克萨菲瑞优选用镥金属化。 迄今为止，黑素瘤已经用光动力疗法治疗难以治愈。

公开(公告)号：US06270749B1

公开(公告)日：2001-08-07

申请号：US09329720

申请日：1999-06-10

申请人： Mark S. Blumenkranz ,  Kathryn W. Woodburn ,  Richard A. Miller ,  Stuart W. Young

发明人： Mark S. Blumenkranz ,  Kathryn W. Woodburn ,  Richard A. Miller ,  Stuart W. Young

IPC分类号： A61K4900

CPC分类号： A61K41/0076 ,  A61K49/0021 ,  Y10S514/912

摘要： The use of texaphyrins for ocular diagnosis and therapy is provided, especially use of photosensitive texaphyrins for photodynamic therapy of conditions of the eye characterized by abnormal vasculature, such as macular degeneration, or pterygium, for example. The photosensitive texaphyrin may be a free-base texaphyrin or may be metallated with a diamagnetic metal. Preferably, the photosensitive texaphyrin is metallated with lutetium. Due to the dual wavelength absorption of texaphyrins, i.e., at 400-500 nm and at 700-800 nm, especially about 732 nm, as compared to porphyrins, texaphyrins are more effective and versatile for use in humans as compared to porphyrins. Texaphyrins serve as effective contrast agents in ocular angiography.

摘要翻译： 提供了泰克萨菲瑞用于眼部诊断和治疗的用途，特别是使用感光性泰克萨菲瑞用于光动力学治疗眼睛状况的特征是异常脉管系统，例如黄斑变性或翼状ium肉。 感光性泰克萨菲瑞可以是游离碱泰克萨菲瑞，也可以用抗磁性金属进行金属化。 优选地，感光性泰克萨菲瑞用镥金属化。 由于与卟啉相比，泰克萨菲瑞的双波长吸收，即在400-500nm和700-800nm，特别是约732nm，与卟啉相比，泰克萨菲素在人类中更有效和通用。 Texaphyrins作为眼部血管造影术中的有效造影剂。

公开(公告)号：US6022526A

公开(公告)日：2000-02-08

申请号：US903099

申请日：1997-07-30

申请人： Kathryn W. Woodburn ,  Stuart W. Young

发明人： Kathryn W. Woodburn ,  Stuart W. Young

IPC分类号： A61K49/00 ,  G01N33/574

CPC分类号： A61K49/0036 ,  G01N33/5743 ,  G01N33/57496

摘要： Melanotic melanoma tumor or cells, melanin, or melanin metabolites are detected, identified, and localized when bound to texaphyrins or texaphyrin metal complexes. The present invention provides texaphyrins and texaphyrin metal complexes as reagents for in vivo or in vitro detection for melanin or melanin metabolites predictive of the presence of melanotic melanoma.

摘要翻译： 当与泰克萨菲林或泰克萨菲瑞金属络合物结合时，检测，鉴定和定位黑色素瘤黑素瘤肿瘤或细胞，黑色素或黑色素代谢物。 本发明提供泰克萨菲精和特沙弗林金属络合物作为预测黑色素黑素瘤存在的黑色素或黑色素代谢物的体内或体外检测的试剂。