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    Process for preparing a therapeutic agent
    2.
    发明授权
    Process for preparing a therapeutic agent 失效
    制备治疗剂的方法

    公开(公告)号：US4054648A

    公开(公告)日：1977-10-18

    申请号：US496814

    申请日：1974-08-12

    申请人： Taro Nagasawa ,  Morio Kuboyama ,  Joji Ono ,  Minoru Saito ,  Tsutomu Kudo ,  Eiji Takahashi ,  Kazuyoshi Doi ,  Kazuhiro Nagata

    发明人： Taro Nagasawa ,  Morio Kuboyama ,  Joji Ono ,  Minoru Saito ,  Tsutomu Kudo ,  Eiji Takahashi ,  Kazuyoshi Doi ,  Kazuhiro Nagata

    IPC分类号： A61K35/50 ,  A61K38/00 ,  A61P35/02

    CPC分类号： A61K35/50

    摘要： Therapeutic agents are prepared by:A. grinding placenta with water or diluted physiological saline to form an emulsion, and acidifying the emulsion with a mixture of aqueous acetic acid and hydrochloric acid, to 0.5 to 2.0N;B. heating the acidified emulsion;C. cooling the emulsion, removing insoluble protein by centrifugation, neutralizing the emulsion with an alkali solution, centrifuging said emulsion to remove insoluble matter and collecting a clear supernatant;D. concentrating the supernatant, and dialyzing the resulting concentrated liquid through a dialysis membrane, or filtrating said supernatant through a membrane filter to obtain a dialyzed fluid or filtrate;E. subjecting the dialyzed fluid or filtrate, after concentration to column chromatography, to obtain any one of fractions, of 0.96 - 1.82 in distribution coefficient with Sephadex G-25, of 0.35 - 1.24 with Sephadex G-15, or of 0.35 - 1.25 with Sephadex G-10; andF. lyophilizing the fraction.

    摘要翻译： 治疗剂通过以下方法制备：

    Granular composition for tobacco filter
    3.
    发明授权
    Granular composition for tobacco filter 失效
    烟草滤芯颗粒组成

    公开(公告)号：US4038992A

    公开(公告)日：1977-08-02

    申请号：US617582

    申请日：1975-09-29

    申请人： Katsuhiro Ogasa ,  Joji Ono ,  Tsutomu Kudo ,  Kazuyoshi Doi ,  Katsuichi Noguchi ,  Kazuo Maeda

    发明人： Katsuhiro Ogasa ,  Joji Ono ,  Tsutomu Kudo ,  Kazuyoshi Doi ,  Katsuichi Noguchi ,  Kazuo Maeda

    IPC分类号： A24D3/06 ,  A24B15/02 ,  A24B15/033

    CPC分类号： A24D3/06

    摘要： A granular composition having a grain size of 10 to 50 mesh and a bulk density of 0.5 to 0.7 g/cm.sup.3 suitable for use in a tobacco filter or a tobacco pipe and having the ability to selectively remove carcinogenic and deleterious components from tobacco smoke comprises granules which are composed of bovine milk whey protein power and/or egg white protein powder, and one or more excipients selected from the group consisting of powdered cellulose, wheat flour, starch, rice flour, sugar, glucose, lactose, talc, alumina, zeolite or silica gel; or composite granules which are a blend of said granules and charcoal granules.

    摘要翻译： 适用于烟草过滤嘴或烟草管并具有从烟草烟雾中选择性除去致癌和有害成分的能力的颗粒大小为10至50目，体积密度为0.5至0.7g / cm 3的颗粒组合物包含颗粒 由牛奶乳清蛋白粉和/或蛋白蛋白粉组成的一种或多种赋形剂，以及选自粉状纤维素，小麦粉，淀粉，米粉，糖，葡萄糖，乳糖，滑石，氧化铝，沸石 或硅胶; 或作为所述颗粒和木炭颗粒的混合物的复合颗粒。

    Lactoferrin tablets
    8.
    发明授权
    Lactoferrin tablets 有权
    乳铁蛋白片

    公开(公告)号：US06319895B1

    公开(公告)日：2001-11-20

    申请号：US09341316

    申请日：1999-09-02

    申请人： Mamoru Tomita ,  Ryo Kato ,  Yuzo Asano ,  Kenji Nishi ,  Yuriko Iiyama ,  Tsutomu Kudo

    发明人： Mamoru Tomita ,  Ryo Kato ,  Yuzo Asano ,  Kenji Nishi ,  Yuriko Iiyama ,  Tsutomu Kudo

    IPC分类号： A61K3840

    CPC分类号： A61K9/2018 ,  A61K35/741 ,  A61K38/40 ,  Y10S435/822 ,  Y10S435/853 ,  Y10S435/885 ,  A61K2300/00

    摘要： Lactoferrin tablets comprising as the active ingredients lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg; and lactoferrin tablets comprising as the active ingredients a microbial cell powder of at least one microorganism selected from among lactic acid bacteria, lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg. These tablets can be produced by using the conventional tableting apparatuses and yet have high hardness. Thus, they do not adhere to the inner wall of the oral cavity and have a favorable taste. Since no excessive tableting pressure is needed in the production process, moreover, these tablets can contain much viable cells of lactic acid bacteria, though they are in the form of rigid tablet.

    摘要翻译： 乳铁蛋白片剂包含作为活性成分的乳铁蛋白和乳果糖，并且具有至少4kg的水平硬度和至少3kg的垂直硬度; 以及乳铁蛋白片，其包含至少一种选自乳酸菌，乳铁蛋白和乳果糖中的微生物的微生物细胞粉末作为活性成分，并且具有至少4kg的水平硬度和至少3kg的垂直硬度。 这些片剂可以通过使用常规的压片装置制造，但是具有高的硬度。 因此，它们不粘附到口腔的内壁并具有良好的味道。 由于在生产过程中不需要过量的压片压力，所以这些片剂可以含有很多活细胞的乳酸菌，尽管它们是刚性片剂的形式。