公开(公告)号：US06428781B1

公开(公告)日：2002-08-06

申请号：US09331851

申请日：1999-06-28

申请人： Katsuichi Sakano ,  Nobuyuki Higashihashi ,  Ryuji Hashimoto

发明人： Katsuichi Sakano ,  Nobuyuki Higashihashi ,  Ryuji Hashimoto

IPC分类号： A61K4500

CPC分类号： C07K14/65 ,  A61K38/00 ,  C07K14/4743

摘要： The effects of endogenous insulin-like growth factor can be appreciated by administering compounds capable of increasing free IGF in living bodies. Compounds are described which can elevate the concentration of unbound IGF by converting endogenous IGF (insulin-like growth factor) into free, biologically active IGF or elevating the concentration of the complex of IGF and IGFBP (insulin-like growth factor binding protein) in living bodies. Medicaments can be prepared containing these compounds or these compounds may be used in methods for the prevention and or treatment of IGF-responsive diseases such as diabetes, amyotrophic lateral sclerosis, or osteoporosis.

摘要翻译： 内源性胰岛素样生长因子的作用可以通过施用能够增加活体中游离IGF的化合物来获得。 描述了可以通过将内源性IGF（胰岛素样生长因子）转化为游离的，生物活性的IGF或提高IGF和IGFBP（胰岛素样生长因子结合蛋白）的复合物在生物中的浓度来提高未结合的IGF的浓度的化合物 身体。 可以制备含有这些化合物的药物，或者这些化合物可以用于预防和/或治疗诸如糖尿病，肌萎缩性侧索硬化或骨质疏松症的IGF-应答疾病的方法。

公开(公告)号：US5142046A

公开(公告)日：1992-08-25

申请号：US754198

申请日：1991-08-28

申请人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

发明人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

IPC分类号： A61K31/50 ,  C07B57/00 ,  C07D265/36 ,  C07D413/06 ,  C07D498/06

CPC分类号： C07D413/06 ,  C07D265/36

摘要： An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.

摘要翻译： 公开了光学活性吡啶并苯并恶嗪衍生物，其制备方法和可用于制备光学活性吡啶并苯并恶嗪衍生物的新型中间体。 光学活性的吡啶并苯并恶嗪衍生物具有增加的抗微生物活性和降低的毒性。 中间体可用于制备诸如氧氟沙星和anolog化合物之类的光学活性吡啶并苯并恶嗪衍生物。

公开(公告)号：US5053407A

公开(公告)日：1991-10-01

申请号：US876623

申请日：1986-06-20

申请人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

发明人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

IPC分类号： A61K31/50 ,  C07B57/00 ,  C07D265/36 ,  C07D413/06 ,  C07D498/06

CPC分类号： C07D413/06 ,  C07D265/36

摘要： An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.

公开(公告)号：US4985557A

公开(公告)日：1991-01-15

申请号：US327653

申请日：1989-03-23

申请人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

发明人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

IPC分类号： A61K31/50 ,  C07B57/00 ,  C07D265/36 ,  C07D413/06 ,  C07D498/06

CPC分类号： C07D413/06 ,  C07D265/36

摘要： An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.

摘要翻译： 公开了光学活性吡啶并苯并恶嗪衍生物，其制备方法和可用于制备光学活性吡啶并苯并恶嗪衍生物的新型中间体。 光学活性的吡啶并苯并恶嗪衍生物具有增加的抗微生物活性和降低的毒性。 中间体可用于制备诸如氧氟沙星和anolog化合物之类的光学活性吡啶并苯并恶嗪衍生物。