公开(公告)号：US20110189299A1

公开(公告)日：2011-08-04

申请号：US13001751

申请日：2009-07-01

申请人： Katsuyuki Okubo ,  Chieko Kitaura ,  Kenjiro Minomi ,  Elizabeth Pearson ,  Clive J. Roberts ,  Martyn C. Davies ,  Snjezana Stolnik-Trenkic ,  Lisbeth Illum

发明人： Katsuyuki Okubo ,  Chieko Kitaura ,  Kenjiro Minomi ,  Elizabeth Pearson ,  Clive J. Roberts ,  Martyn C. Davies ,  Snjezana Stolnik-Trenkic ,  Lisbeth Illum

IPC分类号： A61K9/14 ,  A61K39/00 ,  A61K38/02 ,  A61K38/28 ,  A61K31/711 ,  A61K31/713 ,  A61K31/715 ,  A61K31/422 ,  A61K31/137 ,  A61K31/7105 ,  A61P37/04

CPC分类号： A61K9/1676 ,  A61K9/0043 ,  A61K9/19 ,  A61K31/137 ,  A61K31/195 ,  A61K31/4045 ,  A61K31/715 ,  A61K47/32 ,  A61K47/34 ,  A61K47/42

摘要： The invention provides a pharmaceutical composition that can be used for efficient administration of low-molecular weight drugs and polymeric compounds such as peptides and proteins by methods other than injection, as well as a method for producing the composition. The pharmaceutical composition is for transmucosal administration and comprises (a) a drug having a positive or negative charge at a predetermined pH, (b) a pharmaceutically acceptable small particle and (c) a pharmaceutically acceptable surface-coating polymer capable of being electrically charged at the pH, wherein the surface of the small particle is coated by the surface-coating polymer, the drug is immobilized on the surface of the small particle via the surface-coating polymer, and a complex is formed by a noncovalent interaction between the small particle and the surface-coating polymer and a concurrent electrostatic interaction between the surface-coating polymer and the drug.

摘要翻译： 本发明提供了一种可用于通过注射以外的方法有效施用低分子量药物和聚合物如肽和蛋白质的药物组合物，以及制备该组合物的方法。 所述药物组合物用于经粘膜给药，并且包含（a）在预定pH下具有正电荷或负电荷的药物，（b）药学上可接受的小颗粒和（c）能够被电荷充电的药学上可接受的表面包衣聚合物 pH值，其中小颗粒的表面被表面涂层聚合物涂覆，药物通过表面涂层聚合物固定在小颗粒的表面上，并且通过小颗粒之间的非共价相互作用形成络合物 表面涂层聚合物和表面涂层聚合物与药物之间的并发静电相互作用。

公开(公告)号：US20120244196A1

公开(公告)日：2012-09-27

申请号：US13499876

申请日：2010-10-01

申请人： Katsuyuki Okubo ,  Toshihiko Okazaki ,  Chieko Kitaura ,  Kenjiro Minomi ,  Elizabeth Pearson ,  Clive J. Roberts ,  Martyn C. Davies ,  Snjezana Stolnik-Trenkic ,  Lisbeth Illum

发明人： Katsuyuki Okubo ,  Toshihiko Okazaki ,  Chieko Kitaura ,  Kenjiro Minomi ,  Elizabeth Pearson ,  Clive J. Roberts ,  Martyn C. Davies ,  Snjezana Stolnik-Trenkic ,  Lisbeth Illum

IPC分类号： A61K9/14 ,  A61K38/38 ,  A61K38/28

CPC分类号： A61K9/19 ,  A61K9/146 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K31/715 ,  A61K33/00 ,  A61K33/14 ,  A61K33/30 ,  A61K38/28 ,  A61K39/385 ,  A61K39/39 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/55555 ,  C12N15/88 ,  A61K2300/00

摘要： The invention provides a pharmaceutical composition that can be used for an efficient administration of a water-soluble polymer drug by a method other than injection, and a method for production of the pharmaceutical composition. The pharmaceutical composition contains a small particle comprised of (a) a water-soluble drug and (b) a pharmaceutically acceptable ionic crystalline compound which is solid at room temperature, wherein the ionic crystalline compound is crystallized in the small particle.

摘要翻译： 本发明提供了可以通过除了注射以外的方法有效施用水溶性聚合物药物的药物组合物和药物组合物的制造方法。 药物组合物含有由（a）水溶性药物和（b）在室温下为固体的药学上可接受的离子结晶化合物组成的小颗粒，其中离子结晶化合物在小颗粒中结晶。

公开(公告)号：US4687144A

公开(公告)日：1987-08-18

申请号：US874151

申请日：1986-06-13

申请人： Jere F. Irwin ,  John R. Doornink ,  Clive J. Roberts

发明人： Jere F. Irwin ,  John R. Doornink ,  Clive J. Roberts

IPC分类号： B02C18/14 ,  B02C23/32 ,  B29B13/10 ,  B29B17/04 ,  B02C18/44

CPC分类号： B29B17/0412 ,  B02C18/142 ,  B02C18/148 ,  B02C23/32 ,  B29B13/10 ,  B29L2007/008 ,  Y02W30/625

摘要： An apparatus for comminuting waste material such as waste plastic sheet material, into progressively smaller pieces until a desired size is reached that may be recycled. The apparatus has a set of slowly rotating, intermeshing scissor rolls for receiving the waste material and shearing the material into smaller pieces. A paddle wheel conveyor receives the smaller pieces from the scissor rolls and moves the smaller pieces over a screen with the undersized smaller pieces passing through the screen defining the desired reduced size. The oversized smaller pieces that do not pass through the screen are reprocessed back to the scissor rolls by the paddle wheel conveyor. A vacuum pump draws air through the apparatus and the screen to facilitate the separation on the screen and entrains the undersized pieces in an air stream to convey the pieces from the apparatus.

摘要翻译： 用于将诸如废塑料片材的废料粉碎成逐渐变小的装置，直到达到可被再循环的所需尺寸。 该装置具有一组缓慢旋转的相互啮合的剪刀辊，用于接收废料并将材料剪切成更小的片。 桨轮传送器从剪刀辊接收较小的片，并将较小的片移动到屏幕上，而较小尺寸的较小片通过屏幕，限定所需的减小的尺寸。 不通过筛网的尺寸较小的较小的碎片通过桨轮输送机重新加工回剪刀辊。 真空泵通过设备和屏幕吸入空气，以便于屏幕上的分离，并将小尺寸的片段夹带在空气流中以将装置输送。