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公开(公告)号：US20110052599A1
公开(公告)日：2011-03-03
申请号：US12818055
申请日：2010-06-17
IPC分类号： A61K39/395 , C12N5/075 , A61K38/18 , A61K31/55 , A61K31/7052 , C12Q1/02 , A61P15/08 , A61B17/43
CPC分类号： C12N5/0609 , C12N2501/13 , C12N2517/10
摘要： Compositions and methods are provided for enhancing the survival and promoting the maturation of mammalian oocytes, zygotes and preimplantation embryos. BDNF or BDNF agonists may be administered to an individual, or to cells in vitro, to enhance cellular maturation, embryo growth and fertilization. Accordingly, compositions comprising BDNF are herein presented for use in promoting in vivo oocyte maturation as well as for use as a component in culture media for promoting preimplantation maturation of zygotes and embryos, for instance, for use with in vitro fertilization procedures and for the production of stem cells. Additionally, compounds that interfere with the binding of BDNF to its receptor may be administered to an individual to prevent oocyte maturation, thereby acting as a contraceptive. The BNDF receptor, TrkB, and BDNF also find use in the screening and design of agonists and antagonists for use in the methods of the invention.
摘要翻译： 提供组合物和方法用于增强哺乳动物卵母细胞，合子和植入前胚胎的存活和促进成熟。 BDNF或BDNF激动剂可以在体外施用于个体或细胞，以增强细胞成熟，胚胎生长和受精。 因此，本文提供了包含BDNF的组合物用于促进体内卵母细胞成熟以及用作培养基中的组分，用于促进受精卵和胚胎的植入前成熟，例如用于体外受精程序和用于生产 的干细胞。 此外，干扰BDNF与其受体的结合的化合物可以施用于个体以防止卵母细胞成熟，从而起避孕作用。 BNDF受体，TrkB和BDNF也用于筛选和设计用于本发明方法的激动剂和拮抗剂。
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2.发明授权公开(公告)号：US07763462B2
公开(公告)日：2010-07-27
申请号：US11762606
申请日：2007-06-13
CPC分类号： C12N5/0609 , C12N2501/13 , C12N2517/10
摘要： Compositions and methods are provided for enhancing the survival and promoting the maturation of mammalian oocytes, zygotes and preimplantation embryos. BDNF or BDNF agonists may be administered to an individual, or to cells in vitro, to enhance cellular maturation, embryo growth and fertilization. Accordingly, compositions comprising BDNF are herein presented for use in promoting in vivo oocyte maturation as well as for use as a component in culture media for promoting preimplantation maturation of zygotes and embryos, for instance, for use with in vitro fertilization procedures and for the production of stem cells. Additionally, compounds that interfere with the binding of BDNF to its receptor may be administered to an individual to prevent oocyte maturation, thereby acting as a contraceptive. The BNDF receptor, TrkB, and BDNF also find use in the screening and design of agonists and antagonists for use in the methods of the invention.
摘要翻译： 提供组合物和方法用于增强哺乳动物卵母细胞，合子和植入前胚胎的存活和促进成熟。 BDNF或BDNF激动剂可以在体外施用于个体或细胞，以增强细胞成熟，胚胎生长和受精。 因此，本文提供了包含BDNF的组合物用于促进体内卵母细胞成熟以及用作培养基中的组分，用于促进受精卵和胚胎的植入前成熟，例如用于体外受精程序和用于生产 的干细胞。 此外，干扰BDNF与其受体的结合的化合物可以施用于个体以防止卵母细胞成熟，从而起避孕作用。 BNDF受体，TrkB和BDNF也用于筛选和设计用于本发明方法的激动剂和拮抗剂。
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3.发明授权In vitro exposure of immature oocytes to BDNF enhances generation of embryonic stem cells 有权未成熟卵母细胞体外暴露于BDNF可增强胚胎干细胞的产生公开(公告)号：US08445281B2
公开(公告)日：2013-05-21
申请号：US12818055
申请日：2010-06-17
IPC分类号： C12N15/00
CPC分类号： C12N5/0609 , C12N2501/13 , C12N2517/10
摘要： Compositions and methods are provided for enhancing the survival and promoting the maturation of mammalian oocytes, zygotes and preimplantation embryos. BDNF or BDNF agonists may be administered to an individual, or to cells in vitro, to enhance cellular maturation, embryo growth and fertilization. Accordingly, compositions comprising BDNF are herein presented for use in promoting in vivo oocyte maturation as well as for use as a component in culture media for promoting preimplantation maturation of zygotes and embryos, for instance, for use with in vitro fertilization procedures and for the production of stem cells. Additionally, compounds that interfere with the binding of BDNF to its receptor may be administered to an individual to prevent oocyte maturation, thereby acting as a contraceptive. The BNDF receptor, TrkB, and BDNF also find use in the screening and design of agonists and antagonists for use in the methods of the invention.
摘要翻译： 提供组合物和方法用于增强哺乳动物卵母细胞，合子和植入前胚胎的存活和促进成熟。 BDNF或BDNF激动剂可以在体外施用于个体或细胞，以增强细胞成熟，胚胎生长和受精。 因此，本文提供了包含BDNF的组合物用于促进体内卵母细胞成熟以及用作培养基中的组分，用于促进受精卵和胚胎的植入前成熟，例如用于体外受精程序和用于生产 的干细胞。 此外，干扰BDNF与其受体的结合的化合物可以施用于个体以防止卵母细胞成熟，从而起避孕作用。 BNDF受体，TrkB和BDNF也用于筛选和设计用于本发明方法的激动剂和拮抗剂。
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