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    Furan or thiopene derivative and medicinal use thereof
    1.
    发明申请
    Furan or thiopene derivative and medicinal use thereof 失效
    呋喃或噻吩衍生物及其医药用途

    公开(公告)号：US20060100261A1

    公开(公告)日：2006-05-11

    申请号：US10526507

    申请日：2003-09-04

    申请人： Kazumasa Hamamura ,  Shigekazu Sasaki ,  Yuichiro Amano ,  Junichi Sakamoto ,  Kohji Fukatsu

    发明人： Kazumasa Hamamura ,  Shigekazu Sasaki ,  Yuichiro Amano ,  Junichi Sakamoto ,  Kohji Fukatsu

    IPC分类号： A61K31/40 ,  A61K31/381 ,  A61K31/34 ,  C07D333/22 ,  C07D207/30

    CPC分类号： C07D307/42 ,  C07D307/38 ,  C07D307/54 ,  C07D307/68 ,  C07D307/79 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12

    摘要： The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or —S(O)n— (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, —S(O)m—, —C(═O)—N(R3)— or —N(R3)—C(═O)— (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：[其中R是任选取代的烃基或任选取代的杂环基，p是0,1或2，当p是2时，每个R可以相同 或不同的R 1是氢原子或任选取代的烃基，R 2是任选取代的芳族基团，环A是任选取代的单环芳环或任选取代的芳环 取代的双环芳族稠合环，X 1是氧原子或硫原子，X 2是一个键，氧原子或-S（O）n （其中n为0,1或2），Y为键，氧原子，-S（O）m - ， - C（-O）-N（R （O） - （R 3）是氢原子，任选取代的烃 基团或任选取代的杂环基，m为0,1或2），M 1，M 2和M 3可以是 相同或不同，各自独立 键或任选取代的二价脂族烃基，M 4是任选取代的二价脂族烃基]或其盐，其可用作脂质代谢异常的预防和/或治疗剂 ，动脉硬化疾病及其后遗症，糖尿病等。

    Furan or thiophene derivative and medicinal use thereof
    2.
    发明授权
    Furan or thiophene derivative and medicinal use thereof 失效
    呋喃或噻吩衍生物及其医药用途

    公开(公告)号：US07553867B2

    公开(公告)日：2009-06-30

    申请号：US10526507

    申请日：2003-09-04

    申请人： Kazumasa Hamamura ,  Shigekazu Sasaki ,  Yuichiro Amano ,  Junichi Sakamoto ,  Kohji Fukatsu

    发明人： Kazumasa Hamamura ,  Shigekazu Sasaki ,  Yuichiro Amano ,  Junichi Sakamoto ,  Kohji Fukatsu

    IPC分类号： A61K31/341 ,  A61K31/381 ,  C07D307/40 ,  C07D333/14 ,  C07D333/18

    CPC分类号： C07D307/42 ,  C07D307/38 ,  C07D307/54 ,  C07D307/68 ,  C07D307/79 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12

    摘要： The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or —S(O)n— (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, —S(O)m—, —C(═O)—N(R3)— or —N(R3)—C(═O)— (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物：[其中R是任选取代的烃基或任选取代的杂环基，p是0,1或2，当p是2时，每个R可以相同 或不同的，R 1是氢原子或任选取代的烃基，R 2是任选取代的芳族基团，环A是任选取代的单环芳族环或任选取代的双环芳族稠环，X 1是氧原子或硫原子， X 2是键，氧原子或-S（O）n - （其中n是0,1或2），Y是键，氧原子，-S（O）m - ， - C（-O） -N（R3） - 或-N（R3）-C（-O） - （R3是氢原子，任选取代的烃基或任选取代的杂环基，m是0,1或2），M1， M2和M3可以相同或不同，并且各自独立地为键或任选取代的二价脂族烃基，M4是任选取代的二价脂族氢 羰基]或其盐，其可用作脂质代谢异常的预防和/或治疗剂，动脉硬化疾病及其后遗症，糖尿病等。