公开(公告)号：US20070269899A1

公开(公告)日：2007-11-22

申请号：US11563324

申请日：2006-11-27

申请人： Kazutaka SHIMBO ,  Takashi Ohnuki ,  Hiroshi Miyano

发明人： Kazutaka SHIMBO ,  Takashi Ohnuki ,  Hiroshi Miyano

IPC分类号： G01N27/62 ,  G01N30/06 ,  G01N30/34 ,  G01N30/72 ,  G01N30/88

CPC分类号： G01N33/6809 ,  G01N30/88 ,  G01N2030/8813 ,  G01N2030/8818 ,  Y10T436/145555 ,  Y10T436/24

摘要： The present invention provides a method and apparatus for analyzing compounds with amino group(s) contained in biological organisms. In this method, a compound with amino group(s) is derivatized and then the derivative of the compound with amino group(s) is eluted by liquid chromatography using a stepwise elution means on a concentration gradient. Subsequently, the derivative of the compound with amino group(s) eluted from the liquid chromatography is detected by mass spectrometry.

摘要翻译： 本发明提供了一种用于分析生物有机体中含有氨基的化合物的方法和装置。 在该方法中，将具有氨基的化合物衍生化，然后通过液相色谱法使用逐步洗脱方法在浓度梯度上洗脱具有氨基的化合物的衍生物。 随后，通过质谱检测从液相色谱法洗脱出的具有氨基的化合物的衍生物。

公开(公告)号：US07494815B2

公开(公告)日：2009-02-24

申请号：US11563324

申请日：2006-11-27

申请人： Kazutaka Shimbo ,  Takashi Ohnuki ,  Hiroshi Miyano

发明人： Kazutaka Shimbo ,  Takashi Ohnuki ,  Hiroshi Miyano

IPC分类号： G01N27/62 ,  G01N30/72

CPC分类号： G01N33/6809 ,  G01N30/88 ,  G01N2030/8813 ,  G01N2030/8818 ,  Y10T436/145555 ,  Y10T436/24

摘要： The present invention provides a method and apparatus for analyzing compounds with amino group(s) contained in biological organisms. In this method, a compound with amino group(s) is derivatized and then the derivative of the compound with amino group(s) is eluted by liquid chromatography using a stepwise elution means on a concentration gradient. Subsequently, the derivative of the compound with amino group(s) eluted from the liquid chromatography is detected by mass spectrometry.

摘要翻译： 本发明提供了一种用于分析生物有机体中含有氨基的化合物的方法和装置。 在该方法中，将具有氨基的化合物衍生化，然后通过液相色谱法使用逐步洗脱方法在浓度梯度上洗脱具有氨基的化合物的衍生物。 随后，通过质谱检测从液相色谱法洗脱出的具有氨基的化合物的衍生物。

公开(公告)号：US4943652A

公开(公告)日：1990-07-24

申请号：US270514

申请日：1988-11-14

申请人： Masanobu Yatagai ,  Takashi Ohnuki

发明人： Masanobu Yatagai ,  Takashi Ohnuki

IPC分类号： B01J31/14 ,  C07B53/00 ,  C07B61/00 ,  C07C27/00 ,  C07C29/143 ,  C07C31/02 ,  C07C33/26 ,  C07C41/26 ,  C07C43/178 ,  C07C67/00 ,  C07C67/31 ,  C07C69/675 ,  C07C69/732 ,  C07C69/734 ,  C07C231/12 ,  C07C235/06 ,  C07D307/33

CPC分类号： C07C67/31 ,  C07C231/18 ,  C07C29/143 ,  C07C41/26 ,  C07B2200/07

摘要： There is disclosed a process for asymmetrically reducing a carbonyl compound, which comprises reducing the carbonyl compound by the use of a reducing agent comprising (i) an optically active tartaric acid or ester thereof and (ii) a metal borohydride, thereby producing an optically active hydroxyl compound. The process can be used for the production of optically active hydroxyesters and alcohols from ketoesters and ketones. These products are useful for the production of medicaments and liquid crystals.

公开(公告)号：US20100012278A1

公开(公告)日：2010-01-21

申请号：US12448572

申请日：2007-12-26

申请人： Takashi Ohnuki ,  Mutsuo Nakajima ,  Kazumasa Kinoshita

发明人： Takashi Ohnuki ,  Mutsuo Nakajima ,  Kazumasa Kinoshita

IPC分类号： B01D1/14 ,  B01J7/02

CPC分类号： B65D51/1611 ,  B01D1/14 ,  B01J2219/00283 ,  B01J2219/00344 ,  B01L3/50825 ,  B01L2200/0678 ,  B01L2300/048

摘要： A vessel 1 comprises a container 2 for storing a sample solution containing a volatile substance and a stopper 3. The stopper 3 is formed with a through-pore 3a at the center, through which a vaporized volatile substance is discharged with exhaust gas. The stopper 2 is formed with a gas inlet port 3b and a gas outlet port 3c at the upper and lower edges, respectively, and a groove 3d connecting the both ports 3b and 3c at the side surface. On reducing pressure in the container 2, an external gas is blown into the container 2 from the gas outlet port 3c through the groove 3d at high speed and spirally rotates by centrifugal force along the inner wall of the container 2. This kicks up the sample solution to stir it, increasing the surface area of the solution and thus promoting vaporizing of the volatile substance.

摘要翻译： 容器1包括用于储存含有挥发性物质和止挡件3的样品溶液的容器2.塞子3在中心形成有通气孔3a，汽化的挥发性物质通过该通孔排出废气。 止动件2分别在上边缘和下边缘处形成有气体入口3b和气体出口3c，以及在侧表面连接两个端口3b和3c的凹槽3d。 在减小容器2的压力的同时，外部气体从气体出口3c通过槽3d高速吹入容器2，并通过离心力沿着容器2的内壁螺旋旋转。这样可以将样品 溶液搅拌，增加溶液的表面积，从而促进挥发性物质的蒸发。