公开(公告)号：US20230234015A1

公开(公告)日：2023-07-27

申请号：US18008592

申请日：2021-07-01

申请人： Avantium Technologies B.V.

发明人： Tom Nijbacker ,  Robbert Arnold de Graaf

IPC分类号： B01J19/00 ,  C40B60/14

CPC分类号： B01J19/0046 ,  C40B60/14 ,  B01J2219/00283 ,  B01J2219/00335 ,  B01J2219/00376 ,  B01J2219/00601

摘要： A system for pressurising parallel batch reactors, and a process for using such to pressurize batch reactors to a pressure of between 20 and 150 barg. The reactors are closed by a removable reactor closure system for covering the mouth of such reactor, wherein the closure system comprises an elastomeric septum and a rigid member with a small hole covering the septum. The septum may be pierced with a specific hollow needle, e.g. to force pressurized gas in the reactor, which pressure can be maintained for prolonged periods after withdrawing the needle. The closure system does not require moving parts.

公开(公告)号：US20180231536A1

公开(公告)日：2018-08-16

申请号：US15952958

申请日：2018-04-13

申请人： Theranos IP Company, LLC

发明人： Tammy BURD ,  Ian GIBBONS ,  Elizabeth A. HOLMES ,  Gary FRENZEL ,  Anthony Joseph NUGENT

IPC分类号： G01N33/53 ,  G01N35/10 ,  A61B5/15 ,  G01N35/02 ,  G01N35/00 ,  G01N33/94 ,  G01N33/68 ,  G01N33/574 ,  G01N33/569 ,  G01N33/543 ,  G01N1/38 ,  B01L9/00 ,  B01L7/00 ,  B01L3/00 ,  B01L3/02 ,  B01J19/00 ,  A61B5/151 ,  A61B10/00 ,  A61B10/02

CPC分类号： G01N33/5304 ,  A61B5/15 ,  A61B5/150755 ,  A61B5/151 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/007 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/543 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/0097 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/9129 ,  G01N2800/26 ,  G01N2800/60 ,  G16H10/40 ,  Y10T29/49826 ,  Y10T436/25375

摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US09757706B2

公开(公告)日：2017-09-12

申请号：US14402943

申请日：2013-05-24

申请人： The University Court of the University of Glasgow

发明人： Leroy Cronin

IPC分类号： B01J19/00 ,  C40B50/04 ,  C40B60/08

CPC分类号： B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/007 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00738 ,  B01J2219/00747 ,  B01J2219/00756 ,  C40B50/04 ,  C40B60/08

摘要： The invention provides a method for preparing a compound or a product having one or more characteristics that meet or exceed a user specification, the process comprising the step of selecting a first combination of chemical inputs, optionally together with physical inputs, and supplying those inputs to a reaction space, thereby to generate a first product; analyzing one or more characteristics of the product generated; comparing the one or more characteristics against a user specification; using a genetic algorithm selecting a second combination of chemical inputs, optionally together with physical inputs, wherein the second combination differs from the first combination, and supplying those inputs to the reaction space, thereby to generate a second product; analyzing one or more characteristics of the second product generated; comparing the one or more characteristics generated against the user specification; repeating the selecting and analyzing steps for further individual combinations of chemical and/or physical inputs, to provide an array of products wherein the flow chemistry system operates continuously to provide the first, second and further products, thereby to identify one or more products meeting or exceeding the user specification.

公开(公告)号：US20170058334A1

公开(公告)日：2017-03-02

申请号：US15096114

申请日：2016-04-11

申请人： Clondiag Chip Technologies GmbH

发明人： Torsten Schulz ,  Eugen Ermantraut ,  Ralf Ehricht ,  Klaus- Peter Mobius ,  Gerd Wagner ,  Joachim Fischer ,  Thomas Ellinger

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6837 ,  B01J2219/00283 ,  B01J2219/00529 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01L3/50 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0851 ,  C40B40/06 ,  C40B60/14 ,  C40B70/00 ,  G01N21/253 ,  G01N33/54366 ,  C12Q2547/101

摘要： The invention relates to a reaction vessel, a device and a method for detecting specific interactions between molecular target and probe molecules. The present invention especially relates to a reaction vessel which has a shape and size typical of a laboratory reaction vessel and in which a supporting element with probe molecules immobilised thereon on predetermined regions is arranged on its base surfaces.

摘要翻译： 本发明涉及一种用于检测分子靶和探针分子之间的特异性相互作用的反应容器，装置和方法。 本发明特别涉及一种反应容器，其具有典型的实验室反应容器的形状和尺寸，其中在预定区域上固定有探针分子的支撑元件布置在其基面上。

公开(公告)号：US20170016904A1

公开(公告)日：2017-01-19

申请号：US15217360

申请日：2016-07-22

申请人： Theranos, Inc.

发明人： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC分类号： G01N33/574 ,  G01N35/10 ,  G01N35/02 ,  G01N35/00 ,  G01N33/543

CPC分类号： G01N33/5304 ,  A61B5/15 ,  A61B5/150755 ,  A61B5/151 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/007 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/543 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/0097 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/9129 ,  G01N2800/26 ,  G01N2800/60 ,  G16H10/40 ,  Y10T29/49826 ,  Y10T436/25375

摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20160266108A1

公开(公告)日：2016-09-15

申请号：US15160491

申请日：2016-05-20

申请人： Theranos, Inc.

发明人： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC分类号： G01N33/543 ,  G01N35/00 ,  G01N35/10

CPC分类号： G01N33/5304 ,  A61B5/15 ,  A61B5/150755 ,  A61B5/151 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/007 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/543 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/0097 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/9129 ,  G01N2800/26 ,  G01N2800/60 ,  G16H10/40 ,  Y10T29/49826 ,  Y10T436/25375

摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20160161513A1

公开(公告)日：2016-06-09

申请号：US14963030

申请日：2015-12-08

申请人： Theranos, Inc.

发明人： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC分类号： G01N33/94 ,  G01N35/10 ,  G01N33/543

CPC分类号： G01N33/5304 ,  A61B5/15 ,  A61B5/150755 ,  A61B5/151 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/007 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/543 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/0097 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/9129 ,  G01N2800/26 ,  G01N2800/60 ,  G16H10/40 ,  Y10T29/49826 ,  Y10T436/25375

摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20160115092A1

公开(公告)日：2016-04-28

申请号：US14990567

申请日：2016-01-07

申请人： ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBH ,  GESIM-GESELLSCHAFT FUER SILIZIUM-MIKROSYSTEME MBH

发明人： Marco Mueller ,  Steffen Howitz

IPC分类号： C07B59/00 ,  C07H5/02

CPC分类号： C07B59/005 ,  B01J19/004 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00038 ,  B01J2219/0004 ,  B01J2219/00094 ,  B01J2219/00132 ,  B01J2219/00141 ,  B01J2219/00283 ,  B01J2219/00333 ,  B01J2219/00364 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00731 ,  B01J2219/00788 ,  B01J2219/0081 ,  B01J2219/00882 ,  B01J2219/00889 ,  B01J2219/00916 ,  B01J2219/00941 ,  C07B59/00 ,  C07B2200/05 ,  C07H5/02

摘要： The invention relates to a method for the preparation of radiochemical compounds using a device having at least a reaction module, a dosing module, and a storage module, wherein the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module; the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; and at least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module. Substances needed for the preparation of the respective radiochemical compound are introduced into the reaction vessel of the reaction module by means of dosing units, wherein the dosing units can be moved via a pipetting head in x, y directions or in x, y, and z directions.

摘要翻译： 本发明涉及使用至少具有反应模块，剂量模块和储存模块的装置来制备放射化学化合物的方法，其中反应模块具有至少一个具有可闭合的开口的反应容器， 可以将预定的放射化学化合物的制备物引入反应模块的反应容器中，通过该反应装置可以从反应模块的反应容器中除去所制备的放射化学化合物; 所述计量模块具有至少一个移液头，其可相对于所述储存模块和所述反应模块以及x，y和z方向移动，并且还具有至少一个计量单元; 并且在储存模块中形成用于制备各放射化学化合物所需的物质之一的至少一个贮存器。 制备相应的放射化学化合物所需的物质通过计量单元被引入反应模块的反应容器中，其中计量单元可以通过移液头沿x，y方向或x，y和z移动 方向。

公开(公告)号：US20160076977A1

公开(公告)日：2016-03-17

申请号：US14888021

申请日：2013-09-18

申请人： FREESLATE, INC.

发明人： Stephen Lambert ,  John F. Varni ,  Gregor Hsiao

IPC分类号： G01N1/10

CPC分类号： G01N1/10 ,  B01F13/0836 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00373 ,  B01J2219/00376 ,  B01J2219/00389 ,  B01J2219/00481 ,  C40B60/12 ,  C40B60/14 ,  G01N35/10 ,  G01N2001/105 ,  G01N2013/006

摘要： Methods for sampling reactor contents in parallel reactor systems are disclosed. The methods may be used to sample reactor contents in non-atmospheric (e.g., pressurized) reaction vessels.

摘要翻译： 公开了在并联反应器系统中对反应器内容物进行取样的方法。 该方法可用于在非大气压（例如加压）的反应容器中对反应器内容物进行取样。

公开(公告)号：US20150231591A1

公开(公告)日：2015-08-20

申请号：US14625146

申请日：2015-02-18

申请人： Seiko Epson Corporation

发明人： Toshiro MURAYAMA

IPC分类号： B01J19/00

CPC分类号： B01J19/0046 ,  B01J2219/00283 ,  B01J2219/0031 ,  B01J2219/00344 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00722 ,  C12Q1/686

摘要： A nucleic acid amplification reaction vessel includes a first inner wall, and a second inner wall that is arranged opposite to the first inner wall, in which a distance between the first inner wall and the second inner wall is a length in which a nucleic acid amplification reaction solution comes into contact with both the first inner wall and the second inner wall when the nucleic acid amplification reaction solution is poured.

摘要翻译： 核酸扩增反应容器包括第一内壁和与第一内壁相对布置的第二内壁，其中第一内壁和第二内壁之间的距离是核酸扩增的长度 当注入核酸扩增反应溶液时，反应溶液与第一内壁和第二内壁都接触。