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公开(公告)号：US07491405B2
公开(公告)日：2009-02-17
申请号：US11116371
申请日：2005-04-28
申请人： Kazutoh Takesako , Takashi Okada , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okada , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译： 从马拉色氏菌属真菌的基本上纯的，分离的抗原性蛋白质，其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外，可以提供用于马拉色氏菌过敏原的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。
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公开(公告)号：US20080069829A1
公开(公告)日：2008-03-20
申请号：US11116371
申请日：2005-04-28
申请人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译： 从马拉色氏菌属真菌的基本上纯的，分离的抗原性蛋白质，其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外，可以提供用于马拉色氏菌过敏原的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。
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公开(公告)号：US06911208B2
公开(公告)日：2005-06-28
申请号：US10109670
申请日：2002-04-01
申请人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号： A61K38/00 , C07K14/37 , C07K16/14 , C12N15/31 , C12P21/08 , A61K39/35 , A61K39/36 , C12N21/04 , C12N21/06
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergies; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergies, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译： 一种基本上纯的，分离的抗原蛋白，其来源于马拉色氏菌属的真菌，其特征在于所述抗原蛋白具有与过敏患者IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外，可以提供用于马拉色氏菌过敏症的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。
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公开(公告)号：US06432407B1
公开(公告)日：2002-08-13
申请号：US09091097
申请日：1998-06-12
申请人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号： A61K3900
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译： 从马拉色氏菌属真菌的基本上纯的，分离的抗原性蛋白质，其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外，可以提供用于马拉色氏菌过敏原的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。
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