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19 条记录 (耗时 0.027 秒)

    Compounds and methods for treatment and diagnosis of Chlamydial infection
    4.
    发明授权
    Compounds and methods for treatment and diagnosis of Chlamydial infection 失效
    治疗和诊断衣原体感染的化合物和方法

    公开(公告)号：US07384638B2

    公开(公告)日：2008-06-10

    申请号：US10762058

    申请日：2004-01-15

    申请人： Ajay Bhatia ,  Peter Probst ,  Erika Jean Stromberg

    发明人： Ajay Bhatia ,  Peter Probst ,  Erika Jean Stromberg

    IPC分类号： A61K39/00 ,  A61K39/02 ,  C07K14/00 ,  C12N21/04

    CPC分类号： C07K14/295 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  C07K2319/00

    摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

    摘要翻译： 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。

    Modification of interferon alpha production
    5.
    发明授权
    Modification of interferon alpha production 失效
    干扰素α生产的修改

    公开(公告)号：US06962695B1

    公开(公告)日：2005-11-08

    申请号：US09869269

    申请日：1999-12-22

    申请人： Åsa Berglund

    发明人： Åsa Berglund

    IPC分类号： C12P21/02 ,  C07K14/56 ,  C12R1/91 ,  A61K38/21 ,  C12N21/04

    CPC分类号： C07K14/56

    摘要： A process for the production of α-interferon comprising the steps: i) inducing of human leukocytes by means of a virus; ii) treating the leukocytes with an enhancing agent selected from: a) Xanthine, pyrimidinol and pyrimidinone or derivatives of anyone thereof, such as theophylline, 2-amino-5-bromo-6-methyl-4 pyriminidol or thymine; b) an organic solvent selected from the group consisting of non-aromatic ketones, aliphatic or cyclic amides, alkylated aliphatic or cyclic urea derivatives and aliphatic or cyclic sulfoxides, such as N-methyl-2-pyrrolidinone, acetone, 2-butanone, 1,3-dimethyl-2-imidazolidinone, dimethylsulfoxide, 4-methyl-2-pentanone-N-ethyl-2-pyrrolidinone, 2-pyrrolidinone, tetramethylene sulfoxide or N,N-dimethylacetamide; or a combination of the compounds from a) with an organic solvent from b).

    摘要翻译： 一种生产α-干扰素的方法，包括以下步骤：i）通过病毒诱导人白细胞; ii）用选自以下的增强剂处理白细胞：a）黄嘌呤，嘧啶醇和嘧啶酮或其任何一种的衍生物，如茶碱，2-氨基-5-溴-6-甲基-4嘧啶醇或胸腺嘧啶; b）选自非芳族酮，脂族或环状酰胺，烷基化脂族或环状脲衍生物和脂族或环状亚砜的有机溶剂，例如N-甲基-2-吡咯烷酮，丙酮，2-丁酮，1 3-二甲基-2-咪唑啉酮，二甲亚砜，4-甲基-2-戊酮-N-乙基-2-吡咯烷酮，2-吡咯烷酮，四亚甲基亚砜或N，N-二甲基乙酰胺; 或来自a）的化合物与来自b）的有机溶剂的组合。

    Methods and compositions for inhibition of RNA splicing
    6.
    发明授权
    Methods and compositions for inhibition of RNA splicing 失效
    用于抑制RNA剪接的方法和组合物

    公开(公告)号：US06958215B1

    公开(公告)日：2005-10-25

    申请号：US09936146

    申请日：2000-03-15

    申请人： Stephen M. Testa ,  Matthew D. Disney ,  Sergei M. Gryaznov ,  Douglas H. Turner

    发明人： Stephen M. Testa ,  Matthew D. Disney ,  Sergei M. Gryaznov ,  Douglas H. Turner

    IPC分类号： C12N1/20 ,  C12N15/00 ,  C12N15/63 ,  C12Q1/68 ,  C12N21/04

    CPC分类号： C12N15/63

    摘要： A method of inhibiting the self-splicing of a Group I intron is disclosed. The method uses an oligonucleotide having a sequence essentially identical to a guide sequence found in the 5′ flanking exon and terminates with a 3′ ribonucleoside. Usually the oligonucleotide has N3′→P5′ phosphoramidate or N3′→P5′ thiophiosphoramidate linkages rather than phosphodiester linkages. A method of inhibiting the growth of organisms having Group I intron, particularly certain pathogenic fungi including P. carinii, C. albicans, and A. nidulans using the oglionucleotide is also provided.

    摘要翻译： 公开了抑制第I组内含子自剪接的方法。 该方法使用具有与5'侧翼外显子中发现的指导序列基本相同的序列并以3'核糖核苷终止的寡核苷酸。 通常寡核苷酸具有N 3 - →P 5'氨基磷酸酯或N 3 - →P 5'硫代磷酸酰胺键而不是磷酸二酯键。 还提供了一种抑制具有组I内含子生物的生物的方法，特别是某些致病性真菌，包括卡氏肺炎衣原体，白色念珠菌和使用该骨架的构巢曲霉。

    Canine herpes virus alpha transinducing factor nucleic acid molecules
    7.
    发明授权
    Canine herpes virus alpha transinducing factor nucleic acid molecules 有权
    犬疱疹病毒α转导因子核酸分子

    公开(公告)号：US07041813B2

    公开(公告)日：2006-05-09

    申请号：US10156275

    申请日：2002-05-28

    申请人： Elizabeth J. Haanes ,  Rexann S. Frank

    发明人： Elizabeth J. Haanes ,  Rexann S. Frank

    IPC分类号： C12N21/02 ,  C12N21/04 ,  C12P15/82 ,  C07K14/00

    CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  C12N9/1211 ,  C12N2710/16721 ,  C12N2710/16722 ,  C12N2710/16743

    摘要： The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid molecules. The present invention also relates to the use of such genomes and viruses in a variety of applications, including as therapeutic compositions to protect animals from disease. The present invention also relates to novel isolated CHV nucleic acid molecules, to CHV proteins encoded by such nucleic acid molecules, and to antibodies raised against such CHV proteins as well as to the use of such CHV nucleic acid molecules, proteins and antibodies as therapeutic compositions to protect an animal from CHV. The present invention also includes constructs comprising CHV nucleic acid molecules that include heterologous nucleic acid molecules, to recombinant vectors including such constructs, and to the use of such constructs and vectors in the production of recombinant CHV and recombinant CHV genomes.

    摘要翻译： 本发明包括新型重组犬疱疹病毒（CHV）和新型重组CHV基因组，特别是含有异源核酸分子的那些CHV和CHV基因组。 本发明还涉及这些基因组和病毒在各种应用中的应用，包括作为保护动物免受疾病的治疗组合物。 本发明还涉及新的分离的CHV核酸分子，由这样的核酸分子编码的CHV蛋白，以及针对这种CHV蛋白产生的抗体，以及使用这样的CHV核酸分子，蛋白质和抗体作为治疗组合物 保护动物免受CHV的伤害。 本发明还包括包含包含异源核酸分子的CHV核酸分子，包含这种构建体的重组载体的构建体，以及这些构建体和载体在重组CHV和重组CHV基因组的产生中的用途。

    Endo-beta-1,4-glucanase from bacillus
    8.
    发明授权
    Endo-beta-1,4-glucanase from bacillus 有权
    来自芽孢杆菌的内切-β-1,4-葡聚糖酶

    公开(公告)号：US07041488B2

    公开(公告)日：2006-05-09

    申请号：US10479446

    申请日：2002-06-06

    申请人： Helle Outtrup ,  Torben Henriksen ,  Mads Eskelund Bjørnvad

    发明人： Martin Schülein

    IPC分类号： C12N9/24 ,  C12N21/04 ,  C12N19/04 ,  C12N15/74

    CPC分类号： C11D3/386

    摘要： An enzyme exhibiting endo-beta-1,4-glucanase activity (EC 3.2.1.4), which is selected from one of a) a polypeptide encoded by the DNA sequence of positions 1 to 2322 of SEQ ID NO:1,b) a polypeptide produced by culturing a cell comprising the sequence of SEQ ID NO:1 under conditions wherein the DNA sequence is expressed; c) an endo-beta-1,4-glucanase enzyme having a sequence of at least 97% identity to the amino acid sequence of position 1 to position 773 of SEQ ID NO:2, and fragments thereof exhibitng endo-beta-1,4-glucanase activity, and d) a polypeptide having endo-beta-1,4-glucanase activity that is encoded by a polynucleo-tide that hybridizes with the nucleotide sequence shown in positions 1-2322 of SEQ ID NO:1, is useful for detergent and textile applications.

    摘要翻译： 显示内β-1,4-葡聚糖酶活性的酶（EC 3.2.1.4），其选自a）由SEQ ID NO：1的1至2322位的DNA序列编码的多肽之一，b）a 通过在表达DNA序列的条件下培养包含SEQ ID NO：1的序列的细胞产生的多肽; c）具有与SEQ ID NO：2的位置1至位置773的氨基酸序列具有至少97％同一性的序列的内切-β-1,4-葡聚糖酶，并且其片段表现出内切-β-1， 4-葡聚糖酶活性，和d）具有与SEQ ID NO：1所示1-2322位所示的核苷酸序列杂交的多核苷酸编码的具有内切-β-1,4-葡聚糖酶活性的多肽是有用的 用于洗涤剂和纺织品应用。