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    Phenyloxyaniline derivatives
    1.
    发明授权
    Phenyloxyaniline derivatives 有权
    苯氧基苯胺衍生物

    公开(公告)号：US06870069B2

    公开(公告)日：2005-03-22

    申请号：US10699743

    申请日：2003-11-04

    申请人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Tetsuya Suhara ,  Atsuro Nakazato ,  Makoto Goto

    发明人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Tetsuya Suhara ,  Atsuro Nakazato ,  Makoto Goto

    IPC分类号： C07C233/15 ,  C07C233/05 ,  A61K31/16

    CPC分类号： C07C233/15

    摘要： A phenyloxyaniline derivative useful as a ligand for peripheral benzodiazepine receptor having a strong affinity and a high selectivity, which is represented by formula (1): wherein X1 and X2 are same or different and each is hydrogen atom or halogen atom; R1 and R2 are same or different and each is hydrogen atom, an alkyl group having 1 to 10 carbon(s) or a halogen-substituted alkyl group having 1 to 10 carbon(s); and R3 is a halogen-substituted alkyl group having 1 to 5 carbon(s), or a radioisotope thereof.

    摘要翻译： 用作具有强亲合力和高选择性的外部苯并二氮杂受体的配体的苯氧基苯胺衍生物，其由式（1）表示：其中X 1和X 2相同或不同，各自为氢原子或卤素 原子; R 1和R 2相同或不同，各自为氢原子，具有1〜10个碳原子的烷基或具有1〜10个碳原子的卤素取代的烷基; R 3是具有1〜5个碳原子的卤素取代的烷基或其放射性同位素。

    Radioactive Halogen-Labeled Phenyloxyaniline Derivatives
    2.
    发明申请
    Radioactive Halogen-Labeled Phenyloxyaniline Derivatives 审中-公开
    放射性卤素标记苯氧基苯胺衍生物

    公开(公告)号：US20090234162A1

    公开(公告)日：2009-09-17

    申请号：US11884763

    申请日：2005-12-28

    申请人： Kazutoshi Suzuki ,  Tetsuya Suhara ,  Christer Halldin ,  Ming-Rong Zhang ,  Atsuro Nakazato

    发明人： Kazutoshi Suzuki ,  Tetsuya Suhara ,  Christer Halldin ,  Ming-Rong Zhang ,  Atsuro Nakazato

    IPC分类号： C07C233/25

    CPC分类号： A61K51/04 ,  C07B59/001 ,  C07B2200/05 ,  C07C233/88

    摘要： A radioactive halogen-labeled phenyoxyaniline derivative represented by the following formula: wherein R1 represents a group such as an alkyl group; X1, X2, X3 and X4 represent each a hydrogen atom, an alkyl group, an alkoxy group, an alkoxy group carrying 11C introduced thereinto or a radioactive halogen atom, provided that at least one of X1, X2, X3 and X4 represents an alkoxy group carrying 11C introduced thereinto or a radioactive halogen atom; which is a compound useful as a PBR ligand having a high affinity and a high selectivity. In in vitro measurement of PBR, a PBR ligand having a high affinity and a high selectivity is labeled with a radioactive halogen nuclear species so as to enable the measurement of PBR in vivo with the use of means including not only PET but also SPECT. Thus, a compound which is useful in early diagnosing, preventing and treating diseases such as Alzheimer type dementia can be obtained.

    摘要翻译： 由下式表示的放射性卤素标记的苯氧基苯胺衍生物：其中R1表示烷基等基团; X 1，X 2，X 3和X 4各自表示氢原子，烷基，烷氧基，带有11C的烷氧基或放射性卤素原子，条件是X 1，X 2，X 3和X 4中的至少一个表示烷氧基 携带11C的基团或放射性卤素原子; 其是可用作具有高亲和力和高选择性的PBR配体的化合物。 在PBR的体外测量中，具有高亲和力和高选择性的PBR配体用放射性卤素核物种进行标记，以便能够使用不仅包括PET而且还包括SPECT的方法在体内测量PBR。 因此，可以获得可用于早期诊断，预防和治疗诸如阿尔茨海默氏型痴呆症的疾病的化合物。

    PET VISUALIZATION OF AMYLOID-ASSOCIATED NEUROINFLAMMATION IN THE BRAIN
    3.
    发明申请
    PET VISUALIZATION OF AMYLOID-ASSOCIATED NEUROINFLAMMATION IN THE BRAIN 审中-公开
    在脑中的AMYLOID相关神经炎症的PET可视化

    公开(公告)号：US20100055036A1

    公开(公告)日：2010-03-04

    申请号：US12531051

    申请日：2008-03-12

    申请人： Tetsuya Suhara ,  Kazutoshi Suzuki ,  Makoto Higuchi ,  Ming-Rong Zhang ,  Jun Maeda ,  Bin Ji

    发明人： Tetsuya Suhara ,  Kazutoshi Suzuki ,  Makoto Higuchi ,  Ming-Rong Zhang ,  Jun Maeda ,  Bin Ji

    IPC分类号： A61K51/00 ,  C07C233/00

    CPC分类号： A61K51/04 ,  A61B6/037 ,  A61B6/508

    摘要： The present invention relate to a method for monitoring a response to a therapy on a mammal having a neurodegenerative or neuroinflammatory disorder. According to a preferred embodiment, the method comprising the steps of:a) imaging the mammal using a radio-labeled peripheral benzodiazepine receptor ligand;b) administrating in the mammal at least one anti-amyloid or anti-neuroinflammatory agent;c) imaging the mammal of step b) using a radio-labeled peripheral benzodiazepine receptor ligand; andd) detecting the level of CNS neuroinflammation by the signals from the radio-labeled peripheral benzodiazepine receptor ligand.

    摘要翻译： 本发明涉及用于监测对具有神经变性或神经炎症性疾病的哺乳动物的治疗反应的方法。 根据优选实施方案，所述方法包括以下步骤：a）使用放射性标记的外周苯并二氮杂受体配体对哺乳动物进行成像; b）在哺乳动物中施用至少一种抗淀粉样蛋白或抗神经炎症药物; c）使用放射性标记的外周苯并二氮杂受体配体对步骤b）的哺乳动物进行成像; 和d）通过来自放射性标记的外周苯并二氮杂受体配体的信号检测CNS神经炎症的水平。

    Method for synthesizing radioactive ligand having 18F-labeled fluorobenzene ring
    4.
    发明授权
    Method for synthesizing radioactive ligand having 18F-labeled fluorobenzene ring 有权
    合成具有18 F标记氟苯环的放射性配体的方法

    公开(公告)号：US08067648B2

    公开(公告)日：2011-11-29

    申请号：US12161974

    申请日：2006-11-29

    申请人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Katsushi Kumata

    发明人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Katsushi Kumata

    IPC分类号： C07B59/00 ,  C07C231/12 ,  C07C233/25 ,  C07C303/26 ,  C07C309/73

    CPC分类号： C07B59/001 ,  C07B2200/05 ,  C07C233/88 ,  C07C309/00 ,  Y10T436/196666

    摘要： A phenyl tin compound is synthesized by using a derivative having various functional groups and a bromo- or iodo-benzene ring as a labeling material of a radioactive ligand. On the other hand, a novel hydroxytosyl iodobenzene compound having an electron-donating group is obtained by oxidizing iodobenzene having one or more electron-donating groups and reacting it with tosylic acid. Then, a diphenyliodonium salt which is a labeling precursor is synthesized by reacting the resulting compound with various phenyl tin compounds. Finally, a 18F-labeled ligand having various functional groups and a [18F] fluorobenzene ring is synthesized by reacting the resulting diphenyliodonium salt with [18F]F−.

    摘要翻译： 通过使用具有各种官能团的衍生物和溴或碘 - 苯环作为放射性配体的标记材料来合成苯基锡化合物。 另一方面，通过氧化具有一个或多个给电子基团的碘苯并将其与甲苯磺酸反应得到具有给电子基团的新的羟基苯基碘苯化合物。 然后，通过使所得化合物与各种苯基锡化合物反应来合成作为标记前体的二苯基碘鎓盐。 最后，通过使得到的二苯基碘鎓盐与[18 F] F- - 反应合成具有各种官能团和[18 F]氟苯环的18 F标记的配体。

    METHOD FOR SYNTHESIZING RADIOACTIVE LIGAND HAVING 18F-LABELED FLUOROBENZENE RING
    5.
    发明申请
    METHOD FOR SYNTHESIZING RADIOACTIVE LIGAND HAVING 18F-LABELED FLUOROBENZENE RING 有权
    合成具有18F标记荧光素环的放射性配体的方法

    公开(公告)号：US20090069592A1

    公开(公告)日：2009-03-12

    申请号：US12161974

    申请日：2006-11-29

    申请人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Katsushi Kumata

    发明人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Katsushi Kumata

    IPC分类号： C07C309/29 ,  C07C233/65

    CPC分类号： C07B59/001 ,  C07B2200/05 ,  C07C233/88 ,  C07C309/00 ,  Y10T436/196666

    摘要： A phenyl tin compound is synthesized by using a derivative having various functional groups and a bromo- or iodo-benzene ring as a labeling material of a radioactive ligand. On the other hand, a novel hydroxytosyl iodobenzene compound having an electron-donating group is obtained by oxidizing iodobenzene having one or more electron-donating groups and reacting it with tosylic acid. Then, a diphenyliodonium salt which is a labeling precursor is synthesized by reacting the resulting compound with various phenyl tin compounds. Finally, a 18F-labeled ligand having various functional groups and a [18F] fluorobenzene ring is synthesized by reacting the resulting diphenyliodonium salt with [18F]F−.

    摘要翻译： 通过使用具有各种官能团的衍生物和溴或碘 - 苯环作为放射性配体的标记材料来合成苯基锡化合物。 另一方面，通过氧化具有一个或多个给电子基团的碘苯并将其与甲苯磺酸反应得到具有给电子基团的新的羟基苯基碘苯化合物。 然后，通过使所得化合物与各种苯基锡化合物反应来合成作为标记前体的二苯基碘鎓盐。 最后，通过使得到的二苯基碘鎓盐与[18 F] F- - 反应合成具有各种官能团和[18 F]氟苯环的18 F标记的配体。

    Data erasing apparatus
    6.
    发明申请
    Data erasing apparatus 失效
    数据擦除装置

    公开(公告)号：US20050041319A1

    公开(公告)日：2005-02-24

    申请号：US10780602

    申请日：2004-02-19

    申请人： Hiroshi Hasegawa ,  Hisato Suzuki ,  Kazutoshi Suzuki ,  Hiroyuki Uematsu ,  Takahiro Ono

    发明人： Hiroshi Hasegawa ,  Hisato Suzuki ,  Kazutoshi Suzuki ,  Hiroyuki Uematsu ,  Takahiro Ono

    IPC分类号： G11B5/024 ,  G11B23/50 ,  G11B25/04 ,  G11B5/03

    CPC分类号： G11B23/505 ,  G11B5/0245 ,  G11B25/043

    摘要： The invention enables a magnetic disk drive to be inserted and removed against an attraction force exerted by a magnetic force that is strong enough to erase data on a magnetic disk enclosed within a metal case. A converting mechanism comprising a ballscrew and a ballscrew nut bracket is provided that converts rotational motion of a handle into translational motion of an HDD holder; by rotating the handle, the HDD holder with the hard disk drive mounted thereon is moved in the inserting and removing directions by overcoming the attraction force being exerted by the magnetic field generated by means of a permanent magnet. An electric motor may be used to generate the rotational force.

    摘要翻译： 本发明使得能够克服由强力施加的吸引力来插入和移除磁盘驱动器，该磁力足以擦除封闭在金属外壳内的磁盘上的数据。 提供一种包括滚珠丝杠和滚珠丝杠螺母支架的转换机构，其将手柄的旋转运动转换成HDD支架的平移运动; 通过旋转手柄，安装有硬盘驱动器的HDD保持器通过克服由永久磁铁产生的磁场施加的吸引力而沿插入和移除方向移动。 可以使用电动机来产生旋转力。

    Data erasing apparatus
    9.
    发明授权
    Data erasing apparatus 失效
    数据擦除装置

    公开(公告)号：US07027249B2

    公开(公告)日：2006-04-11

    申请号：US10780602

    申请日：2004-02-19

    申请人： Hiroshi Hasegawa ,  Hisato Suzuki ,  Kazutoshi Suzuki ,  Hiroyuki Uematsu ,  Takahiro Ono

    发明人： Hiroshi Hasegawa ,  Hisato Suzuki ,  Kazutoshi Suzuki ,  Hiroyuki Uematsu ,  Takahiro Ono

    IPC分类号： G11B5/03

    CPC分类号： G11B23/505 ,  G11B5/0245 ,  G11B25/043

    摘要： The invention enables a magnetic disk drive to be inserted and removed against an attraction force exerted by a magnetic force that is strong enough to erase data on a magnetic disk enclosed within a metal case. A converting mechanism comprising a ballscrew and a ballscrew nut bracket is provided that converts rotational motion of a handle into translational motion of an HDD holder; by rotating the handle, the HDD holder with the hard disk drive mounted thereon is moved in the inserting and removing directions by overcoming the attraction force being exerted by the magnetic field generated by means of a permanent magnet. An electric motor may be used to generate the rotational force.

    摘要翻译： 本发明使得能够克服由强力施加的吸引力来插入和移除磁盘驱动器，该磁力足以擦除封闭在金属外壳内的磁盘上的数据。 提供一种包括滚珠丝杠和滚珠丝杠螺母支架的转换机构，其将手柄的旋转运动转换成HDD支架的平移运动; 通过旋转手柄，安装有硬盘驱动器的HDD保持器通过克服由永久磁铁产生的磁场施加的吸引力而沿插入和移除方向移动。 可以使用电动机来产生旋转力。