公开(公告)号：US09073885B2

公开(公告)日：2015-07-07

申请号：US10543881

申请日：2004-01-29

申请人： Kazuya Takenouchi ,  Miyuki Anzai ,  Hiroshi Saito ,  Kazuhisa Okada ,  Seiichi Ishizuka ,  Daishiro Miura ,  Hiroaki Takayama ,  Atsushi Kittaka ,  Nozomi Saito ,  Toshie Fujishima

发明人： Kazuya Takenouchi ,  Miyuki Anzai ,  Hiroshi Saito ,  Kazuhisa Okada ,  Seiichi Ishizuka ,  Daishiro Miura ,  Hiroaki Takayama ,  Atsushi Kittaka ,  Nozomi Saito ,  Toshie Fujishima

IPC分类号： A61K31/593 ,  C07D307/58

CPC分类号： C07D307/58 ,  A61K31/593

摘要： A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof; [wherein R1 refers to hydrogen atom, C1-C6 alkyl group optionally substituted with hydrogen group or C1-C6 alkoxy group optionally substituted with hydroxyl group, R2a and R2b refer to hydrogen atom, C1-C10 alkyl group optionally substituted with hydroxyl group, C6-C10 aryl group optionally substituted with hydroxyl group or C7-C12 aralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which R1 is a hydrogen atom or a methyl group and R2a and R2b are hydrogen atoms is excluded].

摘要翻译： 由下式（1）表示的化合物可有效治疗佩吉特氏骨或高钙血症或其医学上可接受的溶剂合物; [其中，R1表示氢原子，可以被氢原子取代的C1-C6烷基或者被羟基取代的C1-C6烷氧基，R2a和R2b表示氢原子，可以被羟基取代的C1-C10烷基，C6 任选被羟基取代的-C 10芳基或任选被羟基取代的C 7 -C 12芳烷基，或被组合以代表亚乙基。 然而，除了R1是氢原子或甲基，R2a和R2b是氢原子的化合物]。

公开(公告)号：US20060148768A1

公开(公告)日：2006-07-06

申请号：US10543881

申请日：2004-01-29

申请人： Kazuya Takenouchi ,  Miyuki Anzai ,  Hiroshi Saito ,  Kazuhisa Okada ,  Seiichi Ishizuka ,  Daishiro Miura ,  Hiroaki Takayama ,  Atsushi Kittaka ,  Nozomi Saito ,  Toshie Fujishima

发明人： Kazuya Takenouchi ,  Miyuki Anzai ,  Hiroshi Saito ,  Kazuhisa Okada ,  Seiichi Ishizuka ,  Daishiro Miura ,  Hiroaki Takayama ,  Atsushi Kittaka ,  Nozomi Saito ,  Toshie Fujishima

IPC分类号： A61K31/59 ,  C07D307/02

CPC分类号： C07D307/58 ,  A61K31/593

摘要： A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof; [wherein R1 refers to hydrogen atom, C1-C6 alkyl group optionally substituted with hydrogen group or C1-C6 alkoxy group optionally substituted with hydroxyl group, R2a and R2b refer to hydrogen atom, C1-C10 alkyl group optionally substituted with hydroxyl group, C6-C10 aryl group optionally substituted with hydroxyl group or C7-C12 aralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which R1 is a hydrogen atom or a methyl group and R2a and R2b are hydrogen atoms is excluded].

摘要翻译： 由下式（1）表示的化合物可有效治疗佩吉特氏骨或高钙血症或其医学上可接受的溶剂合物; [其中R 1是氢原子，任选被氢或C 1 -C 6烷基取代的C 1 -C 6烷基， 任选被羟基取代的C 1 -C 6烷氧基，R 2a和R 2b是指氢原子，C 1〜 任选被羟基取代的C 1 -C 10烷基，任选被羟基取代的C 6 -C 10芳基或C 6 - 任选被羟基取代的或者被组合以代表亚乙基的C 1 -C 12芳烷基。 但是，不包括其中R 1是氢原子或甲基，R 2b和R 2b的氢原子的化合物。

公开(公告)号：US08196414B2

公开(公告)日：2012-06-12

申请号：US12493351

申请日：2009-06-29

申请人： Kenji Nanataki ,  Nozomi Saito ,  Hidetaro Murata

发明人： Kenji Nanataki ,  Nozomi Saito ,  Hidetaro Murata

IPC分类号： F02C9/00

CPC分类号： F02C9/20 ,  F02C3/10 ,  F02C9/54 ,  F05D2260/85 ,  F05D2260/96 ,  F05D2270/024 ,  F05D2270/101 ,  F05D2270/304

摘要： A twin-shaft gas turbine 1, which has a gas generator 2 including a compressor 7, a combustor 8, and a high-pressure turbine 9, is configured to make a first control mode and a second control mode selectively usable for control of the gas generator. In addition, in the first control mode, an IGV angle in the compressor is controlled in accordance with a corrected shaft rotation speed of the gas generator, and in the second control mode, the IGV angle is controlled to maintain a constant gas generator shaft rotation speed. Furthermore, the first control mode is used to start, to stop, and to operate the turbine under fixed or lower load conditions, and that the second control mode is used under operational states other than those to which the first control mode is applied.

摘要翻译： 具有包括压缩机7，燃烧器8和高压汽轮机9的气体发生器2的双轴燃气轮机1构成为能够选择性地用于控制第一控制模式和第二控制模式 气体发生器。 此外，在第一控制模式中，压缩机中的IGV角度根据气体发生器的校正轴转速被控制，在第二控制模式中，控制IGV角度以保持恒定的气体发生器轴旋转 速度。 此外，第一控制模式用于在固定或较低负载条件下启动，停止和操作涡轮机，并且第二控制模式在除了施加第一控制模式的操作状态之外使用。

公开(公告)号：US08272223B2

公开(公告)日：2012-09-25

申请号：US12980120

申请日：2010-12-28

申请人： Kenji Nanataki ,  Nozomi Saito ,  Hidetaro Murata

发明人： Kenji Nanataki ,  Nozomi Saito ,  Hidetaro Murata

IPC分类号： F02C9/00

CPC分类号： F02C9/20 ,  F02C3/10 ,  F02C9/54 ,  F05D2260/85 ,  F05D2260/96 ,  F05D2270/024 ,  F05D2270/101 ,  F05D2270/304

摘要： A twin-shaft gas turbine 1, which has a gas generator 2 including a compressor 7, a combustor 8, and a high-pressure turbine 9, is configured to make a first control mode and a second control mode selectively useable for control of the gas generator. In addition, in the first control mode, an IGV angle in the compressor is controlled in accordance with a corrected shaft rotation speed of the gas generator, and in the second control mode, the IGV angle is controlled to maintain a constant gas generator shaft rotation speed. Furthermore, the first control mode is used to start, to stop, and to operate the turbine under fixed or lower load conditions, and that the second control mode is used under operational states other than those to which the first control mode is applied.

摘要翻译： 具有包括压缩机7，燃烧器8和高压汽轮机9的气体发生器2的双轴燃气轮机1被构造成能够选择性地用于控制第一控制模式和第二控制模式 气体发生器。 此外，在第一控制模式中，压缩机中的IGV角度根据气体发生器的校正轴转速被控制，在第二控制模式中，控制IGV角度以保持恒定的气体发生器轴旋转 速度。 此外，第一控制模式用于在固定或较低负载条件下启动，停止和操作涡轮机，并且第二控制模式在除了施加第一控制模式的操作状态之外使用。