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    Vitamin d3 derivatives and remedies using the same
    2.
    发明申请
    Vitamin d3 derivatives and remedies using the same 审中-公开
    维生素d3衍生物及其使用方法

    公开(公告)号：US20050101575A1

    公开(公告)日：2005-05-12

    申请号：US10503388

    申请日：2003-02-19

    申请人： Karuya Takenouchi ,  Miyuki Anzai ,  Kenji Manabe ,  Seiichi Ishizuka ,  Daishiro Miura

    发明人： Karuya Takenouchi ,  Miyuki Anzai ,  Kenji Manabe ,  Seiichi Ishizuka ,  Daishiro Miura

    IPC分类号： A61P3/02 ,  A61P3/10 ,  A61P3/14 ,  A61P5/18 ,  A61P9/12 ,  A61P11/00 ,  A61P17/02 ,  A61P17/06 ,  A61P17/10 ,  A61P17/14 ,  A61P19/08 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D307/58 ,  A61K31/59 ,  C07D307/02

    CPC分类号： C07D307/58

    摘要： A vitamin D3 derivative expressed by the following general formula (1) [wherein, R is a hydrogen atom or a methyl group, and A is a single bond, —CH2—, —CH═CH—, —CH2—CH═CH—, —CH═CH—CH═CH—, —C≡C— or —CH2—C≡C—; and a compound in which R is an hydrogen atom, A is —CH2—, the steric configuration at the 1-position is (S)-configuration, and the steric configuration at the 3-position is (R)-configuration is excluded] or a pharmaceutically permissible solvate thereof. The compound can be an effective ingredient of a treating agent for osteoporosis, malignant tumor, psoriasis, hyperparathyroidism, an inflammatory respiratory disease, rheumatoid arthritis, growth onset type diabetes mellitus, hypertension, alopecia, acne, dermatitis, hypercalcemia or Paget's disease of bone.

    摘要翻译： 由以下通式（1）表示的维生素D 3 N衍生物[其中，R是氢原子或甲基，A是单键，-CH 2 O / ，-CH-CH-，-CH 2 -CH-CH-，-CH-CH-CH-CH - ， - C≡C-或-CH 2 >-C≡C-; 和其中R为氢原子的化合物，A为-CH 2 - ，1位的空间构型为（S）构型，3位的空间构型为 （R） - 构型]或其药学上可允许的溶剂化物。 该化合物可以是骨质疏松症，恶性肿瘤，牛皮癣，甲状旁腺功能亢进，炎性呼吸系统疾病，类风湿性关节炎，生长发病型糖尿病，高血压，脱发，痤疮，皮炎，高钙血症或佩吉特氏病的治疗剂的有效成分。

    Method of testing myelotoxicity with the use of flow cytometer
    3.
    发明授权
    Method of testing myelotoxicity with the use of flow cytometer 失效
    使用流式细胞仪检测骨髓毒性的方法

    公开(公告)号：US07300763B2

    公开(公告)日：2007-11-27

    申请号：US10297749

    申请日：2001-06-08

    申请人： Daishiro Miura ,  Shoko Ogata ,  Yukiya Koike

    发明人： Daishiro Miura ,  Shoko Ogata ,  Yukiya Koike

    IPC分类号： G01N33/567

    CPC分类号： G01N33/5014 ,  G01N15/14 ,  G01N33/56966 ,  Y10T436/107497

    摘要： The objects of the present invention are to solve low test efficiency and low accuracy which are problems encountered in the conventional methods for testing myelotoxicity of a drug by observing smears. To this end, markers for discriminating and identifying hematopoietic stem cells and blood cells at various differentiation stages in bone marrow are identified. From this point of view, cell surface antigens are specified. Thus, it is found that the myelotoxicity of a drug can be evaluated with a high efficiency at a high accuracy by using flow cytometry to analyze for a change in the quantity of bone marrow-derived cells expressing the cell surface antigens after administration of the drug to an animal.

    摘要翻译： 本发明的目的是解决通过观察涂片测定药物的骨髓毒性的常规方法中遇到的问题的低试验效率和低精度问题。 鉴定鉴别和鉴定骨髓各种分化阶段造血干细胞和血细胞的标记。 从这个角度来说，规定了细胞表面抗原。 因此，通过使用流式细胞术可以高效率地评价药物的骨髓毒性，以分析施用药物后表达细胞表面抗原的骨髓来源的细胞数量的变化 到一个动物

    Glutathione derivatives and their dosage forms
    4.
    发明授权
    Glutathione derivatives and their dosage forms 失效
    谷胱甘肽衍生物及其剂型

    公开(公告)号：US06627732B1

    公开(公告)日：2003-09-30

    申请号：US09673449

    申请日：2000-10-16

    申请人： Kiyoyuki Sakon ,  Yoshimitsu Naniwa ,  Mitsuru Kobayashi ,  Daishiro Miura ,  Hiroshi Imai ,  Atsushi Imaizumi

    发明人： Kiyoyuki Sakon ,  Yoshimitsu Naniwa ,  Mitsuru Kobayashi ,  Daishiro Miura ,  Hiroshi Imai ,  Atsushi Imaizumi

    IPC分类号： C07K508

    CPC分类号： C07K5/0215 ,  A61K38/00

    摘要： The present invention provides a glutathione derivative having a dramatically enhanced hematopoiesis promoting effect in the living body represented by the formula (I): where A represents H or a C1-C20 acyl group; R1 represents a C1-C26 alkyl group or a C3-C26 alkenyl group; and R2 represents H, a C1-C26 alkyl group or a C3-C26 alkyl group, with the proviso that compounds are excluded in which R1 is a C1-C10 alkyl group or a C3-C10 alkenyl group, and simultaneously R2 is H, a C1-C10 alkyl group or a C3-C10 alkenyl group. The present invention also provides a salt of the glutathione derivative, or a colloidal composition that enables the safe and effective development of the effects of the glutathione derivative in the living body.

    摘要翻译： 本发明提供一种在由式（I）表示的活体中具有显着增强的造血作用促进作用的谷胱甘肽衍生物：其中A表示H或C1-C20酰基; R1表示C1-C26烷基或C3-C26烯基; 并且R 2表示H，C 1 -C 26烷基或C 3 -C 26烷基，条件是排除其中R 1为C 1 -C 10烷基或C 3 -C 10烯基的化合物，同时R2为H， C1-C10烷基或C3-C10烯基。 本发明还提供谷胱甘肽衍生物的盐或能够安全有效地发挥生物体中谷胱甘肽衍生物的作用的胶体组合物。