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公开(公告)号：US08404858B2
公开(公告)日：2013-03-26
申请号：US12944326
申请日：2010-11-11
IPC分类号： C07D277/04
CPC分类号： A61K31/426 , A61K9/0019 , A61K31/427 , A61K45/06 , A61K47/6951 , B82Y5/00 , C07D277/20 , C07D277/56 , C07D417/12
摘要： An EP2 agonist which may have an EP3 agonistic effect has an effect of regenerating and/or protecting nerves, and is therefore useful as a therapeutic agent for a disease of the peripheral nervous system, such as a lower or upper motor neuron disease, a nerve root disease, plexopathy, thoracic outlet compression syndrome, peripheral neuropathy, neurofibromatosis and neuromuscular transmission disease. An EP2 agonist which has an EP3 agonistic effect is a safe and effective agent for the regeneration and/or protection of nerves which has little influence on the circulatory system.
摘要翻译： 可能具有EP3激动作用的EP2激动剂具有再生和/或保护神经的作用，因此可用作周围神经系统疾病的治疗剂，例如下部或上部运动神经元疾病，神经 根系疾病，癫痫病，胸出口压迫综合征，周围神经病变，神经纤维瘤病和神经肌肉传播疾病。 具有EP3激动作用的EP2激动剂是对循环系统影响不大的神经的再生和/或保护的安全有效的药剂。
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公开(公告)号：US07863263B2
公开(公告)日：2011-01-04
申请号：US11916374
申请日：2006-06-02
IPC分类号： A61K31/33 , C07D277/04
CPC分类号： A61K31/426 , A61K9/0019 , A61K31/427 , A61K45/06 , A61K47/6951 , B82Y5/00 , C07D277/20 , C07D277/56 , C07D417/12
摘要： An EP2 agonist which may have an EP3 agonistic effect has an effect of regenerating and/or protecting nerves, and is therefore useful as a therapeutic agent for a disease of the peripheral nervous system, such as a lower or upper motor neuron disease, a nerve root disease, plexopathy, thoracic outlet compression syndrome, peripheral neuropathy, neurofibromatosis and neuromuscular transmission disease. An EP2 agonist which has an EP3 agonistic effect is a safe and effective agent for the regeneration and/or protection of nerves which has little influence on the circulatory system.
摘要翻译： 可能具有EP3激动作用的EP2激动剂具有再生和/或保护神经的作用，因此可用作周围神经系统疾病的治疗剂，例如下部或上部运动神经元疾病，神经 根系疾病，癫痫病，胸出口压迫综合征，周围神经病变，神经纤维瘤病和神经肌肉传播疾病。 具有EP3激动作用的EP2激动剂是对循环系统影响不大的神经的再生和/或保护的安全有效的药剂。
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3.发明授权公开(公告)号：US08410281B2
公开(公告)日：2013-04-02
申请号：US13377047
申请日：2010-06-09
IPC分类号： A61K31/426 , C07D277/56
CPC分类号： C07D277/56 , A61K31/426 , A61K45/06 , A61K47/6951 , B82Y5/00 , C07D277/20 , C07D277/36 , C08B37/00
摘要： Since a compound represented by formula (I) wherein all of the symbols are the same as defined in the specification, a salt thereof, a solvate thereof, a prodrug thereof, a mixture with a diastereomer thereof in an arbitrary ratio, or a cyclodextrin clathrate thereof have a contracting activity of bladder detrusor and a relaxing activity of urethral sphincter, they can ameliorate bladder contraction dysfunction and/or urethral relaxation dysfunction, and for example, are effective for underactive bladder. Additionally, the compound of the present invention has little risk of side effects on the urinary system, the circulatory system and the digestive system, and exhibits excellent pharmacokinetics, such as oral absorbability etc. Therefore, the compound of the present invention is useful as a superior agent for preventing, treating and/or ameliorating underactive bladder.
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公开(公告)号：US08501793B2
公开(公告)日：2013-08-06
申请号：US12889731
申请日：2010-09-24
IPC分类号： A61K31/425 , A61K31/19 , A61K31/557
CPC分类号： A61K31/5575 , A61K31/427 , A61K31/429 , A61K31/559 , C07C405/00 , C07D277/56
摘要： It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect of promoting the blood flow in cauda equina tissues (excluding limaprost) are useful as highly safe blood flow promoters for cauda equina tissues and, therefore, are efficacious in preventing and/or treating lumbar pain, lower limb pain, lower limb palsy, intermittent claudication, vesicorectal failure, hypogonadism, etc. caused by cauda equina injuries.
摘要翻译： 旨在为马尾组织提供高度安全有效的血液流动促进剂。 在具有低血压降低作用的前列腺素样化合物中，具有促进马尾组织（不包括利马前列素）中的血流的作用的化合物可用作马尾组织的高度安全的血液流动促进剂，因此有效地预防和/ 或治疗由马尾损伤引起的腰痛，下肢疼痛，下肢麻痹，间歇性跛行，膀胱直肠功能衰竭，性腺机能减退等。
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公开(公告)号：US07833995B2
公开(公告)日：2010-11-16
申请号：US10581619
申请日：2004-12-02
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： A61K31/5575 , A61K31/427 , A61K31/429 , A61K31/559 , C07C405/00 , C07D277/56
摘要： It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect of promoting the blood flow in cauda equina tissues (excluding limaprost) are useful as highly safe blood flow promoters for cauda equina tissues and, therefore, are efficacious in preventing and/or treating lumbar pain, lower limb pain, lower limb palsy, intermittent claudication, vesicorectal failure, hypogonadism, etc. caused by cauda equina injuries.
摘要翻译： 旨在为马尾组织提供高度安全有效的血液流动促进剂。 在具有低血压降低作用的前列腺素样化合物中，具有促进马尾组织（不包括利马前列素）中的血流的作用的化合物可用作马尾组织的高度安全的血液流动促进剂，因此有效地预防和/ 或治疗由马尾损伤引起的腰痛，下肢疼痛，下肢麻痹，间歇性跛行，膀胱直肠功能衰竭，性腺机能减退等。
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公开(公告)号：US20090227644A1
公开(公告)日：2009-09-10
申请号：US11916374
申请日：2006-06-02
IPC分类号： A61K31/425 , C07D277/56 , A61P25/00
CPC分类号： A61K31/426 , A61K9/0019 , A61K31/427 , A61K45/06 , A61K47/6951 , B82Y5/00 , C07D277/20 , C07D277/56 , C07D417/12
摘要： An EP2 agonist which may have an EP3 agonistic effect has an effect of regenerating and/or protecting nerves, and is therefore useful as a therapeutic agent for a disease of the peripheral nervous system, such as a lower or upper motor neuron disease, a nerve root disease, plexopathy, thoracic outlet compression syndrome, peripheral neuropathy, neurofibromatosis and neuromuscular transmission disease. An EP2 agonist which has an EP3 agonistic effect is a safe and effective agent for the regeneration and/or protection of nerves which has little influence on the circulatory system.
摘要翻译： 可能具有EP3激动作用的EP2激动剂具有再生和/或保护神经的作用，因此可用作周围神经系统疾病的治疗剂，例如下部或上部运动神经元疾病，神经 根系疾病，癫痫病，胸出口压迫综合征，周围神经病变，神经纤维瘤病和神经肌肉传播疾病。 具有EP3激动作用的EP2激动剂是对循环系统影响不大的神经的再生和/或保护的安全有效的药剂。
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公开(公告)号：US20070129327A1
公开(公告)日：2007-06-07
申请号：US10581619
申请日：2004-12-02
IPC分类号： A61K31/724 , A61K31/558 , A61K31/557
CPC分类号： A61K31/5575 , A61K31/427 , A61K31/429 , A61K31/559 , C07C405/00 , C07D277/56
摘要： It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect of promoting the blood flow in cauda equina tissues (excluding limaprost) are useful as highly safe blood flow promoters for cauda equina tissues and, therefore, are efficacious in preventing and/or treating lumbar pain, lower limb pain, lower limb palsy, intermittent claudication, vesicorectal failure, hypogonadism, etc. caused by cauda equina injuries.
摘要翻译： 旨在为马尾组织提供高度安全有效的血液流动促进剂。 在具有低血压降低作用的前列腺素样化合物中，具有促进马尾组织（不包括利马前列素）中的血流的作用的化合物可用作马尾组织的高度安全的血液流动促进剂，因此有效地预防和/ 或治疗由马尾损伤引起的腰痛，下肢疼痛，下肢麻痹，间歇性跛行，膀胱直肠功能衰竭，性腺机能减退等。
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公开(公告)号：US20110015238A1
公开(公告)日：2011-01-20
申请号：US12889731
申请日：2010-09-24
IPC分类号： A61K31/429 , C07D417/12 , A61K31/427 , A61P9/12 , A61K31/5575 , C07C405/00 , C07D515/18
CPC分类号： A61K31/5575 , A61K31/427 , A61K31/429 , A61K31/559 , C07C405/00 , C07D277/56
摘要： It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect of promoting the blood flow in cauda equina tissues (excluding limaprost) are useful as highly safe blood flow promoters for cauda equina tissues and, therefore, are efficacious in preventing and/or treating lumbar pain, lower limb pain, lower limb palsy, intermittent claudication, vesicorectal failure, hypogonadism, etc. caused by cauda equina injuries.
摘要翻译： 旨在为马尾组织提供高度安全有效的血液流动促进剂。 在具有低血压降低作用的前列腺素样化合物中，具有促进马尾组织（不包括利马前列素）中的血流的作用的化合物可用作马尾组织的高度安全的血液流动促进剂，因此有效地预防和/ 或治疗由马尾损伤引起的腰痛，下肢疼痛，下肢麻痹，间歇性跛行，膀胱直肠功能衰竭，性腺机能减退等。
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9.发明申请COMPOUND HAVING DETRUSOR MUSCLE-CONTRACTING ACTIVITY AND URETHRAL SPHINCTER MUSCLE-RELAXING ACTIVITY 有权具有抑制性肌肉收缩活性的化合物和URETHRAL SPHINCTER肌肉松弛活性公开(公告)号：US20120088805A1
公开(公告)日：2012-04-12
申请号：US13377047
申请日：2010-06-09
IPC分类号： A61K31/426 , A61P13/02 , A61P13/10 , C07D277/56 , C08B37/16
CPC分类号： C07D277/56 , A61K31/426 , A61K45/06 , A61K47/6951 , B82Y5/00 , C07D277/20 , C07D277/36 , C08B37/00
摘要： Since a compound represented by formula (I) wherein all of the symbols are the same as defined in the specification, a salt thereof, a solvate thereof, a prodrug thereof, a mixture with a diastereomer thereof in an arbitrary ratio, or a cyclodextrin clathrate thereof have a contracting activity of bladder detrusor and a relaxing activity of urethral sphincter, they can ameliorate bladder contraction dysfunction and/or urethral relaxation dysfunction, and for example, are effective for underactive bladder. Additionally, the compound of the present invention has little risk of side effects on the urinary system, the circulatory system and the digestive system, and exhibits excellent pharmacokinetics, such as oral absorbability etc. Therefore, the compound of the present invention is useful as a superior agent for preventing, treating and/or ameliorating underactive bladder.
摘要翻译： 由于其中所有符号与说明书中所定义的相同的式（I）表示的化合物，其盐，其溶剂合物，前药，任意比例的非对映异构体的混合物或环糊精包合物 其具有膀胱逼尿肌的收缩活动和尿道括约肌的放松活动，它们可以改善膀胱收缩功能障碍和/或尿道松弛功能障碍，并且例如对膀胱活动不足有效。 此外，本发明的化合物对尿液系统，循环系统和消化系统几乎没有副作用的风险，并且表现出优异的药代动力学，例如口服吸收性等。因此，本发明的化合物可用作 用于预防，治疗和/或改善膀胱活动不足的优良药剂。
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公开(公告)号：US20150130440A1
公开(公告)日：2015-05-14
申请号：US14539274
申请日：2014-11-12
申请人： Akihiro Kinoshita , Shinji Horio
发明人： Akihiro Kinoshita , Shinji Horio
CPC分类号： H02M1/32 , H02M3/158 , H02M3/1582 , H02M2001/325 , H02M2001/327
摘要： A DC-DC converter includes a voltage conversion circuit boosting a voltage of a DC power supply and supplying the voltage to a load, a bypass circuit provided in parallel to the voltage conversion circuit, a drive circuit turning on and off a switching element of the bypass circuit, and a controller outputting a control signal for controlling the voltage conversion circuit and the drive circuit. A diode is connected in parallel to the switching element so as to be oriented toward a forward direction with respect to the DC power supply. A temperature detector of the drive circuit detects temperature of the diode. The drive circuit maintains the switching element in the on state irrespective of the control signal of the controller when the temperature detector detects a temperature greater than or equal to a predetermined value.
摘要翻译： DC-DC转换器包括升压直流电源的电压并将电压提供给负载的电压转换电路，与电压转换电路并联设置的旁路电路，驱动电路接通和断开开关元件 旁路电路以及输出用于控制电压转换电路和驱动电路的控制信号的控制器。 二极管与开关元件并联连接，以相对于直流电源朝向正方向。 驱动电路的温度检测器检测二极管的温度。 当温度检测器检测到大于或等于预定值的温度时，驱动电路将开关元件保持在接通状态，而与控制器的控制信号无关。
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