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公开(公告)号：US08252583B2
公开(公告)日：2012-08-28
申请号：US12663464
申请日：2008-06-06
CPC分类号： C12N5/0657 , A61K35/12 , C12N2501/155 , C12N2501/22 , C12N2506/02
摘要： A method for inducing differentiation of ES cells into cardiomyocytes, which comprises contacting the ES cells with an agonist for G-CSF receptor.
摘要翻译： 一种诱导ES细胞分化为心肌细胞的方法，其包括将ES细胞与G-CSF受体激动剂接触。
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公开(公告)号：US20110129922A1
公开(公告)日：2011-06-02
申请号：US12663464
申请日：2008-06-06
IPC分类号： C12N5/0735 , C12N5/077 , C07K14/535
CPC分类号： C12N5/0657 , A61K35/12 , C12N2501/155 , C12N2501/22 , C12N2506/02
摘要： A method for inducing differentiation of ES cells into cardiomyocytes, which comprises contacting the ES cells with an agonist for G-CSF receptor.
摘要翻译： 一种诱导ES细胞分化为心肌细胞的方法，其包括将ES细胞与G-CSF受体激动剂接触。
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公开(公告)号：US20130302272A1
公开(公告)日：2013-11-14
申请号：US13988255
申请日：2011-11-17
申请人： Keiichi Fukuda , Shinsuke Yuasa
发明人： Keiichi Fukuda , Shinsuke Yuasa
IPC分类号： A61K38/19
CPC分类号： A61K38/193
摘要： The present invention provides therapeutic agents for diseases associated with skeletal muscle degeneration comprising a granulocyte colony-stimulating factor (G-CSF) as an active ingredient. The therapeutic agents of the present invention are especially effective as therapeutic agents for muscular dystrophy.
摘要翻译： 本发明提供与骨骼肌变性相关的疾病的治疗剂，其包含粒细胞集落刺激因子（G-CSF）作为活性成分。 本发明的治疗剂作为肌营养不良症的治疗剂是特别有效的。
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公开(公告)号：US20130189786A1
公开(公告)日：2013-07-25
申请号：US13641370
申请日：2011-04-15
申请人： Keiichi Fukuda , Shinsuke Yuasa , Tomohisa Seki , Mamoru Hasegawa
发明人： Keiichi Fukuda , Shinsuke Yuasa , Tomohisa Seki , Mamoru Hasegawa
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N5/0696 , C12N2501/2302 , C12N2501/515 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/13 , C12N2506/11 , C12N2510/00
摘要： An object of the present invention is to provide methods for producing iPS cells with low invasivity and high efficiency. The iPS cells can be produced with high efficiency using a method comprising the steps of culturing mononuclear cells derived from peripheral blood for 3 to 14 days in the presence of anti-CD3 antibody, and subjecting the cultured mononuclear cells to dedifferentiation.
摘要翻译： 本发明的目的是提供用于生产低侵入性和高效率的iPS细胞的方法。 可以使用包括以下步骤的方法高效率地制备iPS细胞，所述方法包括在抗CD3抗体存在下培养来自外周血的单核细胞3至14天，并对培养的单核细胞进行去分化。
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5.发明授权公开(公告)号：US07727762B2
公开(公告)日：2010-06-01
申请号：US10574530
申请日：2004-10-04
申请人： Keiichi Fukuda , Shinsuke Yuasa , Hideyuki Okano , Takuya Shimazaki , Uichi Koshimizu , Tomofumi Tanaka , Keijiro Sugimura
发明人： Keiichi Fukuda , Shinsuke Yuasa , Hideyuki Okano , Takuya Shimazaki , Uichi Koshimizu , Tomofumi Tanaka , Keijiro Sugimura
CPC分类号： C12N5/0657 , C12N2501/155 , C12N2506/03
摘要： For a method of inducing differentiation of cardiomyocytes from stem cells, a method is provided to induce efficiently and selectively differentiation of cardiomyocytes by such a method in which the stem cells are cultured to induce differentiation into cardiomyocytes in the presence of a substance that inhibits BMP signaling.
摘要翻译： 为了诱导心肌细胞从干细胞分化的方法，提供了一种通过这样一种方法诱导心肌细胞的有效和选择性分化的方法，其中培养干细胞以在抑制BMP信号的物质存在下诱导分化成心肌细胞 。
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公开(公告)号：US09447432B2
公开(公告)日：2016-09-20
申请号：US13641370
申请日：2011-04-15
申请人： Keiichi Fukuda , Shinsuke Yuasa , Tomohisa Seki , Mamoru Hasegawa
发明人： Keiichi Fukuda , Shinsuke Yuasa , Tomohisa Seki , Mamoru Hasegawa
CPC分类号： C12N15/86 , C12N5/0696 , C12N2501/2302 , C12N2501/515 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/13 , C12N2506/11 , C12N2510/00
摘要： An object of the present invention is to provide methods for producing iPS cells with low invasivity and high efficiency. The iPS cells can be produced with high efficiency using a method comprising the steps of culturing mononuclear cells derived from peripheral blood for 3 to 14 days in the presence of anti-CD3 antibody, and subjecting the cultured mononuclear cells to dedifferentiation.
摘要翻译： 本发明的目的是提供用于生产低侵入性和高效率的iPS细胞的方法。 可以使用包括以下步骤的方法高效率地制备iPS细胞，所述方法包括在抗CD3抗体存在下培养来自外周血的单核细胞3至14天，并对培养的单核细胞进行去分化。
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公开(公告)号：US20120114594A1
公开(公告)日：2012-05-10
申请号：US13319570
申请日：2009-11-16
申请人： Keiichi Fukuda , Shinsuke Yuasa , Mie Hara
发明人： Keiichi Fukuda , Shinsuke Yuasa , Mie Hara
CPC分类号： A61K38/193 , Y10S930/145
摘要： The present invention relates to muscle repair promoters for topical application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.
摘要翻译： 本发明涉及含有作为活性成分的集落刺激因子（CSF）的局部应用的肌肉修复促进剂。 本发明的肌肉修复促进剂在低剂量下表现出其作用，特别是当肌肉内给药时。
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8.发明申请公开(公告)号：US20070134215A1
公开(公告)日：2007-06-14
申请号：US10574530
申请日：2004-10-04
申请人： Keiichi Fukuda , Shinsuke Yuasa , Hideyuki Okano , Takuya Shimazaki , Uichi Koshimizu , Tomofumi Tanaka , Keijiro Sugimura
发明人： Keiichi Fukuda , Shinsuke Yuasa , Hideyuki Okano , Takuya Shimazaki , Uichi Koshimizu , Tomofumi Tanaka , Keijiro Sugimura
CPC分类号： C12N5/0657 , C12N2501/155 , C12N2506/03
摘要： For a method of inducing differentiation of cardiomyocytes from stem cells, a method is provided to induce efficiently and selectively differentiation of cardiomyocytes by such a method in which the stem cells are cultured to induce differentiation into cardiomyocytes in the presence of a substance that inhibits BMP signaling.
摘要翻译： 为了诱导心肌细胞从干细胞分化的方法，提供了一种通过这样一种方法诱导心肌细胞的有效和选择性分化的方法，其中培养干细胞以在抑制BMP信号的物质存在下诱导分化成心肌细胞 。
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9.发明授权Method for promoting muscle repair comprising administering G-CSF at the site of injury 有权用于促进肌肉修复的方法，包括在损伤部位施用G-CSF公开(公告)号：US08841250B2
公开(公告)日：2014-09-23
申请号：US13942270
申请日：2013-07-15
申请人： Keiichi Fukuda
发明人： Keiichi Fukuda , Shinsuke Yuasa , Mie Hara
IPC分类号： A61P17/02 , A61K38/19 , C07K14/535
CPC分类号： A61K38/193 , Y10S930/145
摘要： The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.
摘要翻译： 本发明涉及含有集落刺激因子（CSF）作为活性成分的局部应用的肌肉修复促进剂。 本发明的肌肉修复促进剂在低剂量下表现出其作用，特别是当肌肉内给药时。
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10.发明授权Methods for inducing cell death in pluripotent stem cells and differentiated cells other than cardiac myocytes 有权在多能干细胞和心肌细胞以外的分化细胞中诱导细胞死亡的方法公开(公告)号：US08735152B2
公开(公告)日：2014-05-27
申请号：US13260224
申请日：2010-03-29
申请人： Fumiyuki Hattori , Keiichi Fukuda
发明人： Fumiyuki Hattori , Keiichi Fukuda
CPC分类号： C12N5/0657 , C12N5/0081 , C12N5/0696 , C12N2501/90 , C12N2506/02
摘要： The present invention has as its object developing a method that does not involve genomic modification and which yet is capable of inducing cell death in pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, as well as in differentiated cells other than cardiomyocytes derived from pluripotent stem cells, but not in cardiomyocytes. It has been revealed that by establishing a method capable of inducing cell death in cells other than cardiomyocytes in a very efficient manner by adding a substance having no recognized inherent toxicity or cell death inducing action to the culture conditions for pluripotent stem cells and non-cardiomyocytes, the stated problem can be solved without relying upon genomic modification.
摘要翻译： 本发明的目的是开发一种不涉及基因组修饰并且能够在多能干细胞如胚胎干细胞和诱导的多能干细胞以及除了心肌细胞以外的分化细胞中诱导细胞死亡的方法 来自多能干细胞，但不在心肌细胞中。 已经揭示出，通过向多能干细胞和非心肌细胞的培养条件中加入不具有公认的固有毒性或细胞死亡诱导作用的物质，通过建立能够以非常有效的方式在除心肌细胞之外的细胞中诱导细胞死亡的方法 所述问题可以解决而不依赖于基因组修饰。
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