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公开(公告)号：US06787532B2
公开(公告)日：2004-09-07
申请号：US10066951
申请日：2002-02-04
申请人： Keith Biggadike , Amyn P. Sayani , Ian Buxton , Kenton Reed
发明人： Keith Biggadike , Amyn P. Sayani , Ian Buxton , Kenton Reed
IPC分类号： A61K3158
CPC分类号： A61K31/56 , A61K9/0043 , A61K31/58 , A61K45/06 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/34 , A61K47/44 , Y10S514/826 , A61K2300/00
摘要： There is provided according to the invention a pharmaceutical formulation comprising an aqueous carrier liquid having dissolved therein (a) an ester of fluticasone or a solvate thereof as medicament and (b) a solubilising agent for assisting the solubilisation of the medicament in the aqueous carrier liquid.
摘要翻译： 根据本发明提供了包含其中溶解有（a）氟替卡松或其溶剂化物的酯作为药物的水性载体液体的药物制剂，和（b）用于帮助药物溶解在含水载体液体中的增溶剂 。
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公开(公告)号：US07531528B2
公开(公告)日：2009-05-12
申请号：US10918770
申请日：2004-08-13
申请人： Keith Biggadike , Amyn Sayani , Ian Buxton , Kenton Reed
发明人： Keith Biggadike , Amyn Sayani , Ian Buxton , Kenton Reed
IPC分类号： A61K31/58
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： There is provided according to the invention a pharmaceutical formulation comprising an aqueous carrier liquid having dissolved therein (a) an ester of fluticasone or a solvate thereof as medicament and (b) a solubilizing agent for assisting the solubilization of the medicament in the aqueous carrier liquid.
摘要翻译： 根据本发明提供了一种药物制剂，其包含其中溶解有（a）氟替卡松或其溶剂化物的酯的水性载体液体作为药物，和（b）用于辅助药物溶解在含水载体液体中的增溶剂 。
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公开(公告)号：US20050020549A1
公开(公告)日：2005-01-27
申请号：US10918779
申请日：2004-08-13
申请人： Keith Biggadike , Amyn Sayani , Ian Buxton , Kenton Reed
发明人： Keith Biggadike , Amyn Sayani , Ian Buxton , Kenton Reed
IPC分类号： A61K9/10 , A61K9/00 , A61K31/56 , A61K31/568 , A61K31/57 , A61K31/58 , A61K47/02 , A61K47/18 , A61K47/34 , A61K47/36 , A61K47/38 , A61L9/04 , A61P5/44 , A61P11/02 , A61P29/00 , A61P37/08 , C07J3/00 , C07J17/00 , C07J53/00 , C07J71/00
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof.
摘要翻译： 提供了包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液的药物制剂。
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公开(公告)号：US20050026888A1
公开(公告)日：2005-02-03
申请号：US10918770
申请日：2004-08-13
申请人： Keith Biggadike , Amyn Sayani , Ian Buxton , Kenton Reed
发明人： Keith Biggadike , Amyn Sayani , Ian Buxton , Kenton Reed
IPC分类号： A61K20060101 , A61K31/56 , A61K31/57 , A61K31/58 , A61L9/04 , A61P20060101 , A61P5/44 , A61P11/06 , C07J20060101 , C07J3/00 , C07J17/00 , C07J31/00 , C07J53/00 , C07J71/00
CPC分类号： A61K31/58 , A61K9/0043 , A61K31/56
摘要： There is provided according to the invention a pharmaceutical formulation comprising an aqueous carrier liquid having dissolved therein (a) an ester of fluticasone or a solvate thereof as medicament and (b) a solubilising agent for assisting the solubilisation of the medicament in the aqueous carrier liquid.
摘要翻译： 根据本发明提供了包含其中溶解有（a）氟替卡松或其溶剂化物的酯作为药物的水性载体液体的药物制剂，和（b）用于帮助药物溶解在含水载体液体中的增溶剂 。
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5.发明申请Pharmaceutical formulation comprising an androstane derivative and a solubilising agent in an aqueous liquid carrier 审中-公开在水性液体载体中包含雄甾烷衍生物和增溶剂的药物制剂公开(公告)号：US20050209206A1
公开(公告)日：2005-09-22
申请号：US10503000
申请日：2003-02-04
申请人： Keith Biggadike , Ian Buxton , Peter Daley-Yates , Bettina Fong , Elita Ho , Kenton Reed , Amyn Sayani
发明人： Keith Biggadike , Ian Buxton , Peter Daley-Yates , Bettina Fong , Elita Ho , Kenton Reed , Amyn Sayani
IPC分类号： A61K9/08 , A61K9/00 , A61K31/56 , A61K31/569 , A61K31/57 , A61K31/58 , A61K47/04 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/36 , A61L9/04 , A61P11/02 , A61P27/16 , A61P29/00 , A61P37/08 , C07J3/00 , C07J17/00 , C07J53/00 , C07J71/00
CPC分类号： A61K31/56 , A61K9/0043 , A61K31/58 , A61K45/06 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/34 , A61K47/44 , Y10S514/826 , A61K2300/00
摘要： A pharmaceutical formulation comprising an aqueous carrier liquid having dissolved therein (a) a glucocorticoid of formula (I) wherein R represents a 5 membered heterocyclic aromatic ring containing 1 to 3 heteroatoms selected from O, N and S, optionally substituted by one or more methyl or halogen atoms or a solvate thereof, as a medicament; and (b) a solubilising agent for assisting the solubilisation of the medicament in the aqueous carrier liquid.
摘要翻译： 一种包含其中溶解有水性载体液体的药物制剂（a）式（I）的糖皮质激素，其中R表示含有1至3个选自O，N和S的杂原子的5元杂环芳环，任选被一个或多个甲基 或卤素原子或其溶剂合物作为药物; 和（b）用于辅助药物溶解在含水载体液体中的增溶剂。
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6.发明申请Pharmaceutical formulation comprising an aqueous suspension of an androstane derivative for the treatment of inflammatory and allergic conditions 审中-公开药物制剂，其包含用于治疗炎症和过敏病症的雄甾烷衍生物的水性悬浮液公开(公告)号：US20050164996A1
公开(公告)日：2005-07-28
申请号：US10502902
申请日：2003-02-04
申请人： Keith Biggadike , Ian Buxton , Steven Coote , Rosalyn Nice , Kenton Reed , Amyn Sayani , Avinash Sharma
发明人： Keith Biggadike , Ian Buxton , Steven Coote , Rosalyn Nice , Kenton Reed , Amyn Sayani , Avinash Sharma
IPC分类号： A61K9/10 , A61K9/00 , A61K31/56 , A61K31/568 , A61K31/57 , A61K31/58 , A61K47/02 , A61K47/18 , A61K47/34 , A61K47/36 , A61K47/38 , A61L9/04 , A61P5/44 , A61P11/02 , A61P29/00 , A61P37/08 , C07J3/00 , C07J17/00 , C07J53/00 , C07J71/00
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof.
摘要翻译： 提供了包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液的药物制剂。
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公开(公告)号：US20120142651A1
公开(公告)日：2012-06-07
申请号：US13370493
申请日：2012-02-10
申请人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
发明人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a method of treatment of allergic rhinitis which comprises administering to a patient a pharmaceutically acceptable amount of a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof, wherein the administration is once-per-day and intranasal, and the total daily dose of the compound (I) is 50 to 100 μg.
摘要翻译： 提供了一种治疗过敏性鼻炎的方法，其包括给予患者药学上可接受量的药物制剂，其包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液，其中所述给药是每天一次 和鼻内，化合物（I）的总日剂量为50〜100μg。
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公开(公告)号：US20100311706A1
公开(公告)日：2010-12-09
申请号：US12858940
申请日：2010-08-18
申请人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
发明人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a method of treatment of allergic rhinitis which comprises administering to a patient a pharmaceutically acceptable amount of a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof, wherein the administration is once-per-day and intranasal, and the total daily dose of the compound (I) is 50 to 100 μg.
摘要翻译： 提供了一种治疗过敏性鼻炎的方法，其包括给予患者药学上可接受量的药物制剂，其包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液，其中所述给药是每天一次 和鼻内，化合物（I）的总日剂量为50〜100μg。
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9.发明授权Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases 有权嘌呤衍生物用于治疗过敏性，炎性和感染性疾病公开(公告)号：US08765772B2
公开(公告)日：2014-07-01
申请号：US13058470
申请日：2009-08-07
申请人： Keith Biggadike , Diane Mary Coe , Xiao Qing Lewell , Charlotte Jane Mitchell , Stephen Allan Smith , Naimisha Trivedi
发明人： Keith Biggadike , Diane Mary Coe , Xiao Qing Lewell , Charlotte Jane Mitchell , Stephen Allan Smith , Naimisha Trivedi
IPC分类号： A61K31/522 , C07D473/34
CPC分类号： A61K31/522 , A61K9/0043 , A61K31/55 , A61K45/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07D473/16 , C07D473/18
摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。
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10.发明申请公开(公告)号：US20140051720A1
公开(公告)日：2014-02-20
申请号：US14110437
申请日：2012-04-05
申请人： Keith Biggadike , Gianpaolo Bravi , Aurelie Cecile Champigny , Diane Mary Coe , Deborah Needham , Dainiel Terence Tape
发明人： Keith Biggadike , Gianpaolo Bravi , Aurelie Cecile Champigny , Diane Mary Coe , Deborah Needham , Dainiel Terence Tape
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A compound of formula (I) wherein X represents a H atom, or a CH2OH group, Y represents a H atom, or a CH2OH group, but X and Y are not both CH2OH groups and Ar is selected from or a pharmaceutically acceptable salt thereof.
摘要翻译： 式（I）的化合物，其中X表示H原子，或CH 2 OH基，Y表示H原子或CH 2 OH基，但X和Y不同时为CH 2 OH基，Ar选自其药学上可接受的盐 。
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