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    TRPV1 agonist compounds and methods for making and using the same
    1.
    发明申请
    TRPV1 agonist compounds and methods for making and using the same 有权
    TRPV1激动剂化合物及其制备和使用方法

    公开(公告)号：US20060240097A1

    公开(公告)日：2006-10-26

    申请号：US11411328

    申请日：2006-04-25

    申请人： Gene Jamieson ,  Naweed Muhammad ,  Keith Bley

    发明人： Gene Jamieson ,  Naweed Muhammad ,  Keith Bley

    IPC分类号： A61K31/24 ,  A61K9/48 ,  C07C235/72

    CPC分类号： C07C233/20 ,  A61K47/55 ,  A61K47/60 ,  C07C233/18 ,  C07C2601/14

    摘要： Described here are TRPV1 agonist compounds and their methods of synthesis and use. In addition to specifically identified compounds, capsaicin prodrugs, gemini dimers, and mutual prodrugs are also described. Formulations of the TRPV1 agonist compounds may be in the form of a liquid, tablets, capsules, gel, cream, emulsion, a patch, or the like. Methods for treating medical conditions using the compounds, compositions, or prodrugs described, are also provided.

    摘要翻译： 这里描述的是TRPV1激动剂化合物及其合成和使用方法。 除了具体鉴定的化合物之外，还描述了辣椒素前药，双子二聚体和共同前药。 TRPV1激动剂化合物的制剂可以是液体，片剂，胶囊，凝胶，霜剂，乳剂，贴剂等的形式。 还提供了使用所述化合物，组合物或前药治疗医学病症的方法。

    Low-concentration capsaicin patch and methods for treating neuropathic pain
    2.
    发明申请
    Low-concentration capsaicin patch and methods for treating neuropathic pain 审中-公开
    低浓度辣椒素贴剂和治疗神经性疼痛的方法

    公开(公告)号：US20060222690A1

    公开(公告)日：2006-10-05

    申请号：US11396161

    申请日：2006-03-30

    申请人： Keith Bley

    发明人： Keith Bley

    IPC分类号： A61K31/16 ,  A61F13/02 ,  A61L15/16

    CPC分类号： A61K9/7069 ,  A61K31/16 ,  A61K31/165 ,  A61L24/0084 ,  A61K2300/00

    摘要： Described here are patches and methods for treating neuropathic pain. In some variations, the neuropathic pain-relieving patch comprises capsaicin or a capsaicin analog, wherein the concentration of the capsaicin or capsaicin analog is less than 1% by weight, and a penetration enhancer, wherein the patch is capable of relieving neuropathic pain over a sustained period of time. The penetration enhancer may be any suitable penetration enhancer. The patches may also include oils, viscosity increasing agents, and the like. In some variations, the pain-relieving patches comprise capsaicin, or an, wherein the concentration of the capsaicin or analog is less than 1%, and a penetration enhancer, whereby delivery of capsaicin from the patch continues for at least an hour, and whereby a single use of the patch provides a therapeutic benefit for at least one month, two months, or three months. Methods for treating neuropathic pain are also described.

    摘要翻译： 这里描述了治疗神经性疼痛的补丁和方法。 在一些变型中，神经性疼痛缓解贴片包括辣椒素或辣椒素类似物，其中辣椒素或辣椒素类似物的浓度小于1重量％，并且渗透促进剂，其中所述贴剂能够缓解神经性疼痛 持续时间 渗透增强剂可以是任何合适的渗透增强剂。 贴剂还可以包括油，增粘剂等。 在一些变型中，止痛剂包括辣椒素，或其中辣椒素或类似物的浓度小于1％，以及渗透促进剂，其中来自贴片的辣椒素的递送持续至少1小时，由此 补丁的单次使用可提供至少一个月，两个月或三个月的治疗益处。 还描述了治疗神经性疼痛的方法。

    Device for delivery of TRPV1 agonists
    3.
    发明申请
    Device for delivery of TRPV1 agonists 审中-公开
    TRPV1激动剂输送装置

    公开(公告)号：US20060204561A1

    公开(公告)日：2006-09-14

    申请号：US11354349

    申请日：2006-02-14

    申请人： Naweed Muhammad ,  Gene Jamieson ,  Keith Bley

    发明人： Naweed Muhammad ,  Gene Jamieson ,  Keith Bley

    IPC分类号： A61K36/81 ,  A61K31/16 ,  A61F13/02

    CPC分类号： A61K31/565 ,  A61K9/7084 ,  A61K31/16 ,  A61K36/81

    摘要： Described here are drug delivery devices including an occlusive backing layer and a drug depot containing a TRPV1 agonist and a non-hydrophilic solvent. The drug depot may take various forms, such as an adhesive polymeric matrix, liquid reservoir, or microreservoir droplets. Methods of making and using the drug delivery devices are also described.

    摘要翻译： 这里描述了药物递送装置，其包括闭塞背衬层和含有TRPV1激动剂和非亲水溶剂的药物贮库。 药物库可以采取各种形式，例如粘合剂聚合物基质，液体储存器或微储层液滴。 还描述了制备和使用药物递送装置的方法。

    Oils of capsaicinoids and methods of making and using the same
    6.
    发明申请
    Oils of capsaicinoids and methods of making and using the same 有权
    辣椒素油及其制作和使用方法

    公开(公告)号：US20060233901A1

    公开(公告)日：2006-10-19

    申请号：US11394495

    申请日：2006-03-31

    申请人： Gene Jamieson ,  Naweed Muhammad ,  Keith Bley

    发明人： Gene Jamieson ,  Naweed Muhammad ,  Keith Bley

    IPC分类号： A61K36/81

    CPC分类号： C09D5/1625 ,  A01N49/00 ,  A01N65/00 ,  A01N65/08 ,  A23K20/111 ,  A23K50/75 ,  A61K31/165 ,  A61K36/81 ,  A01N25/02

    摘要： Oils of capsaicinoids and methods of making and using them are described. In some variations, the oils of capsaicinoids comprise at least 40% w/w capsaicinoid and a solvent capable of solubilizing the capsaicinoid, wherein the oil of capsaicinoid is substantially free of capsaicinoid crystals or capsaicinoid precipitates. In other variations, the oils of capsaicinoids consist essentially of at least 40% w/w capsaicinoid and a solvent capable of solubilizing the capsaicinoid. The solvent may be a semi-volatile solvent, a non-volatile solvent, or a volatile solvent, and the oil may comprise at least 50% w/w capsaicinoid, 60% w/w capsaicinoid, 70% w/w capsaicinoid, 80% w/w capsaicinoid, 90% w/w capsaicinoid, or 95% w/w capsaicinoid. The oil of capsaicinoid may also include a crystallization inhibitor.

    摘要翻译： 描述了辣椒素的油以及制造和使用它们的方法。 在一些变型中，辣椒素类油包含至少40％w / w辣椒素和能够溶解辣椒素的溶剂，其中辣椒素类油基本上不含辣椒素晶体或辣椒素沉淀物。 在其它变体中，辣椒素类油基本上由至少40％w / w辣椒素和能够溶解辣椒素的溶剂组成。 溶剂可以是半挥发性溶剂，非挥发性溶剂或挥发性溶剂，并且油可以包含至少50％w / w辣椒素，60％w / w辣椒素，70％w / w辣椒素，80 ％w / w辣椒素，90％w / w辣椒素，或95％w / w辣椒素。 辣椒素油也可以包括结晶抑制剂。