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公开(公告)号：US20060224033A1
公开(公告)日：2006-10-05
申请号：US11095835
申请日：2005-03-31
申请人： Keith Hovis , Khalid Iqbal , Mark Cragun
发明人： Keith Hovis , Khalid Iqbal , Mark Cragun
CPC分类号： C07C2/62 , B01J19/2465 , B01J2219/00006 , B01J2219/00162
摘要： A system and/or process for alkylating hydrocarbons which includes an improved method of safely handling alkylation catalyst is disclosed. The process includes passing the alkylation catalyst from a settler vessel to a catalyst receiving vessel, via a catalyst cooler, for containment therein in the presence of a condensible gas. Also disclosed is a method for controlling the pressure in the catalyst receiving vessel by controlling the rate of removal of vapors.
摘要翻译： 公开了一种用于烷基化烃的系统和/或方法，其包括安全处理烷基化催化剂的改进方法。 该方法包括通过催化剂冷却器将烷基化催化剂从沉降器容器传递到催化剂接收容器，以便在可冷凝气体存在下容纳其中。 还公开了一种通过控制蒸汽除去速率来控制催化剂接收容器中的压力的方法。
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公开(公告)号：US08592374B2
公开(公告)日：2013-11-26
申请号：US13044323
申请日：2011-03-09
申请人： Herbert Mösler , Khalid Iqbal , Inge Grundke-Iqbal
发明人： Herbert Mösler , Khalid Iqbal , Inge Grundke-Iqbal
CPC分类号： C07K5/1008 , A61K38/00 , C07K5/1021
摘要： The present invention relates to a neurotrophic peptide having an amino acid sequence of VGDGGLFEKKL (SEQ ID NO:1), EDQQVHFTPTEG (SEQ ID NO:2) or IPENEADGMPATV (SEQ ID NO:3), and comprising an adamantyl group at the C- and/or N-terminal end.
摘要翻译： 本发明涉及具有VGDGGLFEKKL（SEQ ID NO：1）氨基酸序列，EDQQVHFTPTEG（SEQ ID NO：2）或IPENEADGMPATV（SEQ ID NO：3）的氨基酸序列的神经营养肽，其包含C-末端的金刚烷基， 和/或N末端。
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公开(公告)号：US08349577B2
公开(公告)日：2013-01-08
申请号：US12766391
申请日：2010-04-23
申请人： Khalid Iqbal , Sonia Chalbot , Inge Grundke-Iqbal
发明人： Khalid Iqbal , Sonia Chalbot , Inge Grundke-Iqbal
IPC分类号： C12Q1/34
CPC分类号： C12Q1/44
摘要： A system and method for evaluating blood-neural barrier permeability. Phospholipid liposomes are labeled with a fluorescent phospholipase A2 substrate and exposed to cerebrospinal fluid. The change in fluorescence is monitored to determine PLA2 activity. The PLA2 activity is used to evaluate the permeability and function of the blood-neural barrier.
摘要翻译： 用于评估血液 - 神经屏障渗透性的系统和方法。 磷脂脂质体用荧光磷脂酶A2底物标记并暴露于脑脊液。 监测荧光的变化以确定PLA2活性。 PLA2活性用于评估血液神经屏障的渗透性和功能。
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公开(公告)号：US20110160141A1
公开(公告)日：2011-06-30
申请号：US13044323
申请日：2011-03-09
CPC分类号： C07K5/1008 , A61K38/00 , C07K5/1021
摘要： The present invention relates to a neurotrophic peptide having an amino acid sequence of VGDGGLFEKKL (SEQ ID NO:1), EDQQVHFTPTEG (SEQ ID NO:2) or IPENEADGMPATV (SEQ ID NO:3), and comprising an adamantyl group at the C- and/or N-terminal end.
摘要翻译： 本发明涉及具有VGDGGLFEKKL（SEQ ID NO：1）氨基酸序列，EDQQVHFTPTEG（SEQ ID NO：2）或IPENEADGMPATV（SEQ ID NO：3）的氨基酸序列的神经营养肽，其包含C-末端的金刚烷基， 和/或N末端。
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5.发明申请NMDA receptor antagonists and their use in inhibiting abnormal hyperphosphorylation of microtubule associated protein tau 审中-公开NMDA受体拮抗剂及其用于抑制微管相关蛋白tau异常高磷酸化的用途公开(公告)号：US20120157537A1
公开(公告)日：2012-06-21
申请号：US13134615
申请日：2011-06-10
申请人： Khalid Iqbal , Inge Grundke-Iqbal
发明人： Khalid Iqbal , Inge Grundke-Iqbal
IPC分类号： A61K31/13 , A61P25/16 , A61P25/00 , A61P25/08 , A61P27/06 , A61P31/14 , A61P25/14 , A61P25/36 , A61P25/32 , A61P25/30 , A61P25/04 , A61P33/06 , A61P25/28 , A61P1/16
CPC分类号： A61K31/135 , A61K31/13 , A61K31/132 , A61K31/40 , Y02A50/411
摘要： Aminocyclohexane and aminoalkylcyclohexane compounds, which are systemically-active as NMDA receptor antagonists, are effective in inhibiting abnormal hyperphosphorylation of microtubule associated protein tau, method of treating disorders resulting from or associated with abnormal hyperphosphorylation of microtubule associated protein tau, and pharmaceutical compositions comprising the same.
摘要翻译： 作为NMDA受体拮抗剂具有系统活性的氨基环己烷和氨基烷基环己烷化合物有效抑制微管相关蛋白tau的异常过度磷酸化，治疗由微管相关蛋白tau异常过度磷酸化引起或与之相关的病症的方法，以及包含其的药物组合物 。
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公开(公告)号：US07972563B2
公开(公告)日：2011-07-05
申请号：US12694782
申请日：2010-01-27
申请人： Keith W. Hovis , Khalid Iqbal , Mark R. Cragun
发明人： Keith W. Hovis , Khalid Iqbal , Mark R. Cragun
CPC分类号： C07C2/62 , B01J19/2465 , B01J2219/00006 , B01J2219/00162
摘要： A system for alkylating hydrocarbons which includes an improved method of safely handling alkylation catalyst is disclosed. The process includes passing the alkylation catalyst from a settler vessel to a catalyst receiving vessel, via a catalyst cooler, for containment therein in the presence of a condensible gas. Also disclosed is a method for controlling the pressure in the catalyst receiving vessel by controlling the rate of removal of vapors.
摘要翻译： 公开了一种烷基化烃系统，其包括安全处理烷基化催化剂的改进方法。 该方法包括通过催化剂冷却器将烷基化催化剂从沉降器容器传递到催化剂接收容器，以便在可冷凝气体存在下容纳其中。 还公开了一种通过控制蒸汽除去速率来控制催化剂接收容器中的压力的方法。
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公开(公告)号：US07678957B2
公开(公告)日：2010-03-16
申请号：US11095835
申请日：2005-03-31
申请人： Keith W. Hovis , Khalid Iqbal , Mark R. Cragun
发明人： Keith W. Hovis , Khalid Iqbal , Mark R. Cragun
IPC分类号： C07C2/60
CPC分类号： C07C2/62 , B01J19/2465 , B01J2219/00006 , B01J2219/00162
摘要： A system and/or process for alkylating hydrocarbons which includes an improved method of safely handling alkylation catalyst is disclosed. The process includes passing the alkylation catalyst from a settler vessel to a catalyst receiving vessel, via a catalyst cooler, for containment therein in the presence of a condensible gas. Also disclosed is a method for controlling the pressure in the catalyst receiving vessel by controlling the rate of removal of vapors.
摘要翻译： 公开了一种用于烷基化烃的系统和/或方法，其包括安全处理烷基化催化剂的改进方法。 该方法包括通过催化剂冷却器将烷基化催化剂从沉降器容器传递到催化剂接收容器，以便在可冷凝气体存在下容纳其中。 还公开了一种通过控制蒸汽除去速率来控制催化剂接收容器中的压力的方法。
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公开(公告)号：US20080070263A1
公开(公告)日：2008-03-20
申请号：US11838502
申请日：2007-08-14
申请人： Khalid Iqbal , Michael Flory , Inge Grundke-Iqbal
发明人： Khalid Iqbal , Michael Flory , Inge Grundke-Iqbal
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： A method for diagnosing distinct subgroups of Alzheimer's Disease, the method comprising the steps of obtaining a sample of cerebrospinal fluid and determining the level of ubiquitin, the level of Aβ1-42, and the level of tau present in the sample. Based on the levels of each composition in the cerebrospinal fluid, the sample can be assigned to distinct subgroups, thereby allowing for the diagnosis of Alzheimer's Disease or Alzheimer's Disease pathology in the patient from whom the sample was taken.
摘要翻译： 一种用于诊断阿尔茨海默病的不同亚组的方法，所述方法包括以下步骤：获得脑脊液样品并测定泛素水平，AβAβ1-42水平和存在的tau水平 在样品中。 基于脑脊髓液中每种组成的水平，可以将样品分配到不同的亚组，从而允许诊断患者的阿尔茨海默病或阿尔茨海默病病理学。
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公开(公告)号：US07256003B2
公开(公告)日：2007-08-14
申请号：US10890508
申请日：2004-07-13
申请人： Khalid Iqbal , Michael Flory , Inge Grundke-Ighal
发明人： Khalid Iqbal , Michael Flory , Inge Grundke-Ighal
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2333/9015 , G01N2800/2821
摘要： A method for diagnosing distinct subgroups of Alzheimer's Disease, the method comprising the steps of obtaining a sample of cerebrospinal fluid and determining the level of ubiquitin, the level of Aβ1-42, and the level of tau present in the sample. Based on the levels of each composition in the cerebrospinal fluid, the sample can be assigned to distinct subgroups.
摘要翻译： 一种用于诊断阿尔茨海默病的不同亚组的方法，所述方法包括以下步骤：获得脑脊液样品并测定泛素水平，AβAβ1-42水平和存在的tau水平 在样品中。 根据脑脊液中每种组成的水平，可以将样品分配到不同的亚组。
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公开(公告)号：US20100273196A1
公开(公告)日：2010-10-28
申请号：US12766391
申请日：2010-04-23
申请人： Khalid Iqbal , Sonia Chalbot , Inge Grundke-Iqbal
发明人： Khalid Iqbal , Sonia Chalbot , Inge Grundke-Iqbal
IPC分类号： C12Q1/44
CPC分类号： C12Q1/44
摘要： A system and method for evaluating blood-neural barrier permeability. Phospholipid liposomes are labeled with a fluorescent phospholipase A2 substrate and exposed to cerebrospinal fluid. The change in fluorescence is monitored to determine PLA2 activity. The PLA2 activity is used to evaluate the permeability and function of the blood-neural barrier.
摘要翻译： 用于评估血液 - 神经屏障渗透性的系统和方法。 磷脂脂质体用荧光磷脂酶A2底物标记并暴露于脑脊液。 监测荧光的变化以确定PLA2活性。 PLA2活性用于评估血液神经屏障的渗透性和功能。
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