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1.发明授权公开(公告)号：US08946144B2
公开(公告)日：2015-02-03
申请号：US12520364
申请日：2007-12-21
IPC分类号： A61K38/00 , C07K9/00 , C07F9/6561
CPC分类号： C07K9/008 , A61K38/00 , C07F9/6561
摘要： The present invention is directed to antimicrobial compounds which have an affinity for binding bones. More particularly, the invention is directed to phosphonated derivatives of glycopeptide or lipoglycopeptide antibiotics. These compounds are useful as antibiotics for the prevention or treatment of bone and joint infections, especially for the prevention and treatment of osteomyelitis.
摘要翻译： 本发明涉及对结合骨的亲和力的抗微生物化合物。 更具体地，本发明涉及糖肽或脂多糖抗生素的膦酸化衍生物。 这些化合物可用作预防或治疗骨和关节感染的抗生素，特别是用于预防和治疗骨髓炎。
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2.发明申请公开(公告)号：US20100113333A1
公开(公告)日：2010-05-06
申请号：US12520364
申请日：2007-12-21
CPC分类号： C07K9/008 , A61K38/00 , C07F9/6561
摘要： The present invention is directed to antimicrobial compounds which have an affinity for binding bones. More particularly, the invention is directed to phosphonated derivatives of glycopeptide or lipoglycopeptide antibiotics. These compounds are useful as antibiotics for the prevention or treatment of bone and joint infections, especially for the prevention and treatment of osteomyelitis.
摘要翻译： 本发明涉及对结合骨的亲和力的抗微生物化合物。 更具体地，本发明涉及糖肽或脂多糖抗生素的膦酸化衍生物。 这些化合物可用作预防或治疗骨和关节感染的抗生素，特别是用于预防和治疗骨髓炎。
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3.发明授权Phosphonated Rifamycins and uses thereof for the prevention and treatment of bone and joint infections 有权磷酸化的利福霉素及其用于预防和治疗骨和关节感染的用途公开(公告)号：US08404664B2
公开(公告)日：2013-03-26
申请号：US12063300
申请日：2006-08-11
申请人： Yannick Stephane Rose , Stephane Ciblat , Ting Kang , Adel Rafai Far , Evelyne Dietrich , Yanick Lafontaine , Ranga Reddy
发明人： Yannick Stephane Rose , Stephane Ciblat , Ting Kang , Adel Rafai Far , Evelyne Dietrich , Yanick Lafontaine , Ranga Reddy
IPC分类号： A01N57/00 , A61K31/66 , C07D225/04
CPC分类号： C07F9/6561 , A61K47/548
摘要： The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.
摘要翻译： 本发明涉及膦酸化的利福霉素，以及制备和使用这些化合物的方法。 这些化合物可用作预防和/或治疗骨和关节感染的抗生素，特别是用于预防和/或治疗骨髓炎。
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公开(公告)号：US20110263534A1
公开(公告)日：2011-10-27
申请号：US12063300
申请日：2006-08-11
申请人： Yannick Stephane Rose , Stephane Ciblat , Ting Kang , Adel Rafai Far , Evelyne Dietrich , Yanick Lafontaine , Ranga Reddy
发明人： Yannick Stephane Rose , Stephane Ciblat , Ting Kang , Adel Rafai Far , Evelyne Dietrich , Yanick Lafontaine , Ranga Reddy
IPC分类号： A61K31/675 , A61P31/04 , C07D498/16 , C07D498/06 , C07D498/22
CPC分类号： C07F9/6561 , A61K47/548
摘要： The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.
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5.发明申请PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS 有权磷酸缓释片及其用于预防和治疗骨和关节感染的用途公开(公告)号：US20110178001A1
公开(公告)日：2011-07-21
申请号：US13058518
申请日：2009-08-10
申请人： Evelyne Dietrich , Ranga Reddy , Kelly Tanaka , Ting Kang , Yanick Lafontaine , Adel Rafai Far
发明人： Evelyne Dietrich , Ranga Reddy , Kelly Tanaka , Ting Kang , Yanick Lafontaine , Adel Rafai Far
IPC分类号： A61K31/675 , C07F9/6561 , A61P31/04 , A61K38/14 , A61K38/12
CPC分类号： C07F9/6561 , A61K31/675 , A61K47/548
摘要： The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.
摘要翻译： 本发明涉及膦酸化的利福霉素，以及制备和使用这些化合物的方法。 这些化合物可用作预防和/或治疗骨和关节感染的抗生素，特别是用于预防和/或治疗骨髓炎。
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6.发明申请Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections 审中-公开磷酸化氟喹诺酮类抗生素类抗生素及预防和治疗骨关节感染的方法公开(公告)号：US20080287396A1
公开(公告)日：2008-11-20
申请号：US11912038
申请日：2006-04-21
申请人： Daniel Delorme , Tom Houghton , Ting Kang , Kelly Tanaka , Yanick LaFontaine , Evelyne Dietrich , Adel Rafai Far
发明人： Daniel Delorme , Tom Houghton , Ting Kang , Kelly Tanaka , Yanick LaFontaine , Evelyne Dietrich , Adel Rafai Far
IPC分类号： A61K31/675 , C07D401/02 , A61P31/04
CPC分类号： C07F9/65586 , C07F9/65583 , C07F9/6561
摘要： The present invention relates to phosphonated fluoroquinolones, antibacterial analogs thereof, and methods of using such compounds. These compounds are useful as antibiotics for prevention and/or the treatment of bone and joint infections, especially for the prevention and/or treatment of osteomyelitis.
摘要翻译： 本发明涉及膦酸化氟喹诺酮类，其抗菌类似物和使用这些化合物的方法。 这些化合物可用作预防和/或治疗骨和关节感染的抗生素，特别是用于预防和/或治疗骨髓炎。
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公开(公告)号：US08901072B2
公开(公告)日：2014-12-02
申请号：US13389993
申请日：2010-08-11
申请人： Adel Rafai Far , Kelly Tanaka , Evelyne Dietrich , Ranga Reddy , Ting Kang
发明人： Adel Rafai Far , Kelly Tanaka , Evelyne Dietrich , Ranga Reddy , Ting Kang
CPC分类号： C07K9/008 , A61K38/12 , A61K38/14 , A61K45/06 , A61K47/48038 , A61K47/48046 , A61K47/48215 , A61K47/542 , A61K47/543 , A61K47/60 , A61K2300/00
摘要： The invention relates to derivatives of glycopeptide and lipoglycopeptide antibiotics possessing an altered ionization state with respect to the parent glycopeptide or lipoglycopeptide antibiotic, and having the ability to be regenerated as the parent glycopeptide or lipoglycopeptide antibiotic under physiological conditions. These compounds are useful as antibiotics for the prevention and/or the treatment of bacterial infections.
摘要翻译： 本发明涉及相对于母体糖肽或脂多糖抗生素具有改变的电离状态的糖肽和脂多糖抗生素的衍生物，并且具有在生理条件下作为母体糖肽或脂多糖抗生素再生的能力。 这些化合物可用作预防和/或治疗细菌感染的抗生素。
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公开(公告)号：US20120149632A1
公开(公告)日：2012-06-14
申请号：US13389993
申请日：2010-08-11
申请人： Adel Rafai Far , Kelly Tanaka , Evelyne Dietrich , Ranga Reddy , Ting Kang
发明人： Adel Rafai Far , Kelly Tanaka , Evelyne Dietrich , Ranga Reddy , Ting Kang
CPC分类号： C07K9/008 , A61K38/12 , A61K38/14 , A61K45/06 , A61K47/48038 , A61K47/48046 , A61K47/48215 , A61K47/542 , A61K47/543 , A61K47/60 , A61K2300/00
摘要： The invention relates to derivatives of glycopeptide and lipoglycopeptide antibiotics possessing an altered ionization state with respect to the parent glycopeptide or lipoglycopeptide antibiotic, and having the ability to be regenerated as the parent glycopeptide or lipoglycopeptide antibiotic under physiological conditions. These compounds are useful as antibiotics for the prevention and/or the treatment of bacterial infections.
摘要翻译： 本发明涉及相对于母体糖肽或脂多糖抗生素具有改变的电离状态的糖肽和脂多糖抗生素的衍生物，并且具有在生理条件下作为母体糖肽或脂多糖抗生素再生的能力。 这些化合物可用作预防和/或治疗细菌感染的抗生素。
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9.发明授权Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections 有权磷酸化的利福霉素及其用于预防和治疗骨和关节感染的用途公开(公告)号：US08524691B2
公开(公告)日：2013-09-03
申请号：US13058518
申请日：2009-08-10
申请人： Evelyne Dietrich , Ranga Reddy , Kelly Tanaka , Ting Kang , Yanick LaFontaine , Adel Rafai Far
发明人： Evelyne Dietrich , Ranga Reddy , Kelly Tanaka , Ting Kang , Yanick LaFontaine , Adel Rafai Far
IPC分类号： A01N57/00 , A61K31/66 , C07D225/04
CPC分类号： C07F9/6561 , A61K31/675 , A61K47/548
摘要： The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.
摘要翻译： 本发明涉及膦酸化的利福霉素，以及制备和使用这些化合物的方法。 这些化合物可用作预防和/或治疗骨和关节感染的抗生素，特别是用于预防和/或治疗骨髓炎。
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