公开(公告)号：US5808024A

公开(公告)日：1998-09-15

申请号：US478370

申请日：1995-06-07

申请人： Ken Sasaki ,  Robin E. Harkness ,  Sheena M. Loosmore ,  Michel H. Klein

发明人： Ken Sasaki ,  Robin E. Harkness ,  Sheena M. Loosmore ,  Michel H. Klein

IPC分类号： A61K39/00 ,  A61K39/095 ,  C07K14/21 ,  C07K14/22 ,  C12N5/10 ,  C12N15/31 ,  C12N15/62 ,  C07H21/02

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K2319/02 ,  Y10S530/806 ,  Y10S530/825

摘要： An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, has a molecular mass of about 200 kDa. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

摘要翻译： 分离和纯化的莫拉氏菌属菌株，特别是卡他莫拉氏菌的外膜蛋白具有约200kDa的分子量。 大约200kDa的外膜蛋白以及编码它们的核酸分子可用于诊断应用和免疫原性组合物，特别是用于体内施用于宿主以赋予产生约200kDa外部细菌病原体引起的疾病的保护 产生能够在与约200kDa外膜蛋白特异性反应的宿主中诱导抗体的蛋白质。

公开(公告)号：US06448386B2

公开(公告)日：2002-09-10

申请号：US08945567

申请日：1998-03-19

申请人： Ken Sasaki ,  Robin E. Harkness ,  Sheena M. Loosmore ,  Pele Chong ,  Michel H. Klein

发明人： Ken Sasaki ,  Robin E. Harkness ,  Sheena M. Loosmore ,  Pele Chong ,  Michel H. Klein

IPC分类号： C07H2102

CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/02 ,  C12N2799/022 ,  C12N2799/023 ,  Y02A50/466 ,  Y10S424/803

摘要： An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

摘要翻译： 提供分离和纯化的具有约200kDa分子量的莫拉氏菌属菌株，特别是卡他莫拉氏菌的外膜蛋白。 大约200kDa的外膜蛋白以及编码它们的核酸分子可用于诊断应用和免疫原性组合物，特别是用于体内施用于宿主以赋予产生约200kDa外部细菌病原体引起的疾病的保护 产生能够在与约200kDa外膜蛋白特异性反应的宿主中诱导抗体的蛋白质。

公开(公告)号：US06440425B1

公开(公告)日：2002-08-27

申请号：US08621944

申请日：1996-03-26

申请人： Ken Sasaki ,  Robin E. Harkness ,  Sheena M. Loosmore ,  Pele Chong ,  Michel H. Klein

发明人： Ken Sasaki ,  Robin E. Harkness ,  Sheena M. Loosmore ,  Pele Chong ,  Michel H. Klein

IPC分类号： A61K3902

CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/02 ,  C12N2799/022 ,  C12N2799/023 ,  Y02A50/466 ,  Y10S424/803

摘要： An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

公开(公告)号：US06335018B1

公开(公告)日：2002-01-01

申请号：US08431718

申请日：1995-05-01

申请人： Ken Sasaki ,  Robin E. Harkness ,  Michel H. Klein

发明人： Ken Sasaki ,  Robin E. Harkness ,  Michel H. Klein

IPC分类号： C07K500

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K2319/02 ,  Y02A50/466 ,  Y10S530/806 ,  Y10S530/825

摘要： An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, has a molecular mass of about 200 kDa. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

摘要翻译： 分离和纯化的莫拉氏菌属菌株，特别是卡他莫拉氏菌的外膜蛋白具有约200kDa的分子量。 大约200kDa的外膜蛋白以及编码它们的核酸分子可用于诊断应用和免疫原性组合物，特别是用于体内施用于宿主以赋予产生约200kDa外部细菌病原体引起的疾病的保护 产生能够在与约200kDa外膜蛋白特异性反应的宿主中诱导抗体的蛋白质。

公开(公告)号：US06440424B1

公开(公告)日：2002-08-27

申请号：US08483855

申请日：1995-06-07

申请人： Ken Sasaki ,  Robin E. Harkness ,  Sheena M. Loosmore ,  Michel H. Klein

发明人： Ken Sasaki ,  Robin E. Harkness ,  Sheena M. Loosmore ,  Michel H. Klein

IPC分类号： A61K3902

CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K2319/02 ,  Y02A50/466 ,  Y10S530/806 ,  Y10S530/825

摘要： An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, has a molecular mass of about 200 kDa. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

公开(公告)号：US06391313B1

公开(公告)日：2002-05-21

申请号：US09353617

申请日：1999-07-15

申请人： Sheena M. Loosmore ,  Yan-Ping Yang ,  Michel H. Klein ,  Ken Sasaki

发明人： Sheena M. Loosmore ,  Yan-Ping Yang ,  Michel H. Klein ,  Ken Sasaki

IPC分类号： A61K39116

CPC分类号： A61K39/102 ,  A61K39/1045 ,  A61K2039/55505 ,  A61K2039/70 ,  Y02A50/466

摘要： A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both Haemophilus influenzae and Moraxella catarrhalis. Such composition comprises at least four antigens comprising at least one antigen from Haemophilus influenzae, and at least one antigen from Moraxella catarrhalis. Three of the antigens are adhesins. High molecular weight (HMW) proteins and Haemophilus influenzae adhesin (Hia) proteins of non-typeable Haemophilus and a 200 kDa outer membrane protein of Moraxella catarrhalis comprise the adhesin components while the other antigen is a non-proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The multi-valent immunogenic composition may be combined with DTP component vaccines, which may also include non-virulent poliovirus and PRP-T, to provide a component vaccine without impairment of the immunogenic properties of the other antigens.

摘要翻译： 多价免疫原性组合物赋予免疫宿主免受由流感嗜血杆菌和卡他莫拉菌引起的感染的保护。 这样的组合物包含至少四种抗原，其包含来自流感嗜血杆菌的至少一种抗原和至少一种来自卡他莫拉菌的抗原。 三种抗原是粘附素。 不可分型嗜血杆菌的高分子量（HMW）蛋白和流感嗜血杆菌粘附素（Hia）蛋白和卡他莫拉菌的200kDa外膜蛋白包含粘附素组分，而另一种抗原是Hin47蛋白的非蛋白水解类似物。 每个成分不影响其他成分的免疫原性。 多价免疫原性组合物可以与DTP组分疫苗组合，其也可以包括非毒性脊髓灰质炎病毒和PRP-T，以提供组分疫苗，而不损害其他抗原的免疫原性。

公开(公告)号：US09030589B2

公开(公告)日：2015-05-12

申请号：US14127818

申请日：2012-08-07

申请人： Ken Sasaki ,  Nobuhiro Takeda

发明人： Ken Sasaki ,  Nobuhiro Takeda

IPC分类号： H04N3/14 ,  H04N5/335 ,  H04N5/232 ,  H04N5/359 ,  H04N5/355 ,  H04N5/3745 ,  H01L27/146

CPC分类号： H04N5/359 ,  H01L27/14621 ,  H01L27/14627 ,  H01L27/14641 ,  H04N5/355 ,  H04N5/3559 ,  H04N5/3745

摘要： An image sensor comprises a plurality of pixels, and each pixel having: a plurality of photoelectric conversion units configured to receive light fluxes that pass through different exit pupil regions of an optical system disposed on an object side of the image sensor and accumulate charges, respectively; a separation portion configured to separate the photoelectric conversion units; and setting means configured to selectively set an electric potential of the separation portion to any one of a plurality of electric potentials. Signals can be separately read out from the photoelectric conversion units. Taking an electric potential of a separation portion that separates the plurality of pixels as a reference potential, the plurality of electric potentials include first to third electric potentials; higher than the reference potential, lower than the reference potential, and higher than the reference potential and lower than the first electric potential.

摘要翻译： 图像传感器包括多个像素，并且每个像素具有：多个光电转换单元，被配置为接收通过分别设置在图像传感器的物体侧的光学系统的不同出射光瞳区域的光束并分别积累电荷 ; 分离部，被配置为分离所述光电转换单元; 以及设定装置，被配置为选择性地将分离部分的电位设置为多个电位中的任一个。 信号可以从光电转换单元分别读出。 将多个像素分离为基准电位的分离部分的电位，所述多个电位包括第一至第三电位; 高于参考电位，低于参考电位，并高于参考电位并低于第一电位。

公开(公告)号：US20110092424A1

公开(公告)日：2011-04-21

申请号：US12895517

申请日：2010-09-30

申请人： Ken Sasaki ,  Vanessa Jane Williamson ,  Alberto de Araujo ,  Ewa Walczyk

发明人： Ken Sasaki ,  Vanessa Jane Williamson ,  Alberto de Araujo ,  Ewa Walczyk

IPC分类号： A61K38/00 ,  C07K14/00 ,  C12P21/06 ,  C07H21/04

CPC分类号： C07K14/605 ,  C07K2319/00

摘要： GLP-2 peptides and analogs thereof are produced in high yield and with desired, authentic termini by isolation from a GLP-2 peptide multimer in which at least two units of GLP-2 peptide are coupled through a linker that presents an N-terminal acid cleavage site and a C-terminal enzyme cleavage site. In a specific embodiment, [Gly2]hGLP-2 is produced from a multimeric precursor comprising 2-30 units thereof.

摘要翻译： 通过从其中至少两个单元的GLP-2肽通过呈现N末端酸的连接体偶联的GLP-2肽多聚体分离，以高产率和期望的真实末端产生GLP-2肽及其类似物 切割位点和C末端酶切割位点。 在一个具体实施方案中，[Gly2] hGLP-2由包含其2-30单位的多聚体前体产生。

公开(公告)号：US20110011550A1

公开(公告)日：2011-01-20

申请号：US12921485

申请日：2009-03-25

申请人： Takaharu Noda ,  Masato Ogimoto ,  Katsumasa Ono ,  Ken Sasaki ,  Takeshi Takahashi

发明人： Takaharu Noda ,  Masato Ogimoto ,  Katsumasa Ono ,  Ken Sasaki ,  Takeshi Takahashi

IPC分类号： D21F11/00

CPC分类号： D21H27/002 ,  D21H11/16

摘要： The present invention aims to provide soft and pleasant-to-touch tissue papers for household use with high strength.Provided are a tissue paper for household use characterized in that it contains a pulp obtained by applying an impact force produced during the collapse of bubbles generated by cavitation to pulp fibers and a tissue paper for household use consisting of two or more paper layers characterized in that at least one paper layer contains a pulp obtained by applying an impact force produced during the collapse of bubbles generated by cavitation to pulp fibers.

摘要翻译： 本发明的目的在于提供具有高强度家用的柔软易感的薄纸。 本发明提供一种家用薄页纸，其特征在于，其含有通过将由气蚀产生的气泡崩解产生的冲击力施加到纸浆纤维而获得的纸浆和由两层或多层纸层构成的家用纸巾，其特征在于， 至少一层纸层含有通过将由气蚀产生的气泡崩解产生的冲击力施加到纸浆纤维而获得的纸浆。

公开(公告)号：US20060159709A1

公开(公告)日：2006-07-20

申请号：US11013711

申请日：2004-12-16

申请人： Sheena Loosmore ,  Ken Sasaki ,  Yan Yang ,  Michel Klein

发明人： Sheena Loosmore ,  Ken Sasaki ,  Yan Yang ,  Michel Klein

IPC分类号： A61K39/02 ,  C07H21/04 ,  C12P21/06 ,  C12N15/74 ,  C12N1/21 ,  C07K14/195

CPC分类号： C07K14/212

摘要： An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, having a molecular mass of about 200 kDa, is provided by recombinant means. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

摘要翻译： 通过重组方法提供分离和纯化的分子量为约200kDa的莫拉氏菌属菌株，特别是卡他莫拉氏菌的外膜蛋白。 大约200kDa的外膜蛋白以及编码它们的核酸分子可用于诊断应用和免疫原性组合物，特别是用于体内施用于宿主以赋予产生约200kDa外部细菌病原体引起的疾病的保护 产生能够在与约200kDa外膜蛋白特异性反应的宿主中诱导抗体的蛋白质。