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    Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof
    2.
    发明申请
    Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof 有权
    表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途

    公开(公告)号：US20050287108A1

    公开(公告)日：2005-12-29

    申请号：US11038787

    申请日：2005-01-21

    申请人： William DeGrado ,  Dahui Liu ,  Gregory Tew ,  Michael Klein

    发明人： William DeGrado ,  Dahui Liu ,  Gregory Tew ,  Michael Klein

    IPC分类号： A61K31/74 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78 ,  C07C279/12

    CPC分类号： C07C279/12 ,  A61K31/74 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78

    摘要： The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.

    摘要翻译： 本发明公开了使用表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法，包括但不限于聚合物和低聚物作为抗微生物剂的药物用途和用于与肝素治疗相关的出血并发症的解毒剂。 本发明还公开了新颖的表面两亲聚芳基和聚芳基炔基聚合物和低聚物，新型聚合物和低聚物的组合物，包括药物组合物，以及设计和合成表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法。