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公开(公告)号：US20120029175A1
公开(公告)日：2012-02-02
申请号：US12226199
申请日：2007-04-11
CPC分类号： C07K14/4748 , A61K39/0011 , A61K39/39 , A61K2039/55583 , C07K1/1077
摘要： A process for producing an embedded protein antigen, comprising embedding a protein antigen having two or more cysteine residues in a molecule thereof, into a hydrophobized polysaccharid. Prior to or after the embedding of the protein antigen, the protein antigen is purified. There are provided an embedded protein antigen and a process for producing the same, which can advantageously purify the protein antigen, while suppressing the denaturation of the protein antigen as completely as possible.
摘要翻译： 一种生产嵌入蛋白质抗原的方法，包括将其分子中具有两个或多个半胱氨酸残基的蛋白质抗原嵌入疏水化多糖中。 在嵌入蛋白质抗原之前或之后，纯化蛋白质抗原。 提供嵌入蛋白质抗原及其制备方法，其可以有利地纯化蛋白质抗原，同时尽可能地完全抑制蛋白质抗原的变性。
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公开(公告)号：US20140322344A1
公开(公告)日：2014-10-30
申请号：US14241321
申请日：2012-08-30
IPC分类号： A61K39/385 , A61K39/39
CPC分类号： A61K39/385 , A61K39/0011 , A61K45/06 , A61K47/61 , A61K2039/55511 , A61K2039/55561 , A61K2039/6087 , C07K14/4748 , C07K2319/00 , C07K2319/40 , C12N15/117 , C12N2310/17 , A61K2300/00
摘要： A vaccine preparation for treating cancer includes a complex of a hydrophobized polysaccharide and at least one synthetic long peptide derived from a tumor-specific antigenic protein and/or a pathogen-derived antigenic protein. The at least one synthetic long peptide contains at least one CD8+ cytotoxic T-cell recognition epitope and at least one CD4+ helper T-cell recognition epitope. The complex is simultaneously administered to the patient with at least one immunopotentiating agent.
摘要翻译： 用于治疗癌症的疫苗制剂包括疏水化多糖和衍生自肿瘤特异性抗原蛋白和/或病原体衍生抗原蛋白的至少一种合成长肽的复合物。 所述至少一种合成长肽含有至少一种CD8 +细胞毒性T细胞识别表位和至少一种CD4 +辅助T细胞识别表位。 使用至少一种免疫增强剂将复合物同时施用于患者。
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