公开(公告)号：US20090217402A1

公开(公告)日：2009-08-27

申请号：US11914881

申请日：2006-05-18

申请人： Kenneth Bernstein ,  Xiao Shen

发明人： Kenneth Bernstein ,  Xiao Shen

IPC分类号： A01K67/00 ,  C12N15/00 ,  C12N5/00 ,  A61K35/12 ,  A61K39/00 ,  C12N15/63

CPC分类号： C12N15/1138 ,  C12N9/48

摘要： Methods and compositions are provided for modulating the activity of macrophage and macrophage-like cells, particularly by modulating the peptidase activity of such cells. In certain aspects, methods are provided for enhancing or suppressing the immune function of a host by increasing or decreasing, respectively, expression of a target peptidase in host macrophage and macrophage-like cells. Such methods for enhancing or suppressing the immune function of a host by increasing or inhibiting (suppressing or silencing) expression of a target peptidase in host macrophage and macrophage-like cells find use in methods for treating and/or preventing a number of diseases and conditions, including cancer, viral and/or bacterial infection, Alzheimer's disease, tissue transplant rejection, autoimmune diseases, and chronic inflammatory diseases. The invention also provides compositions and research tools related to these methods, including vectors for increasing or inhibiting the expression of a peptidase in macrophage and macrophage-like cells, macrophage and macrophage-like cells transfected with these vectors, genetically modified mice that over-express a target peptidase or in which expression of a target peptidase has been disrupted, and selective modulators of peptidase activity in macrophages as well as methods for identifying and using such modulators.

摘要翻译： 提供了用于调节巨噬细胞和巨噬细胞样细胞的活性的方法和组合物，特别是通过调节这些细胞的肽酶活性。 在某些方面，通过分别增加或减少宿主巨噬细胞和巨噬细胞样细胞中靶肽酶的表达来提供用于增强或抑制宿主免疫功能的方法。 通过增加或抑制（抑制或沉默）宿主巨噬细胞和巨噬细胞样细胞中靶肽酶的表达来增强或抑制宿主的免疫功能的这些方法可用于治疗和/或预防多种疾病和病症 ，包括癌症，病毒和/或细菌感染，阿尔茨海默病，组织移植排斥，自身免疫疾病和慢性炎性疾病。 本发明还提供了与这些方法相关的组合物和研究工具，包括用于增加或抑制巨噬细胞和巨噬细胞样细胞中巨噬细胞和巨噬细胞样细胞，巨噬细胞和巨噬细胞样细胞表达的载体的载体，用于过表达的转基因小鼠 目标肽酶或靶蛋白酶的表达已被破坏，以及巨噬细胞中肽酶活性的选择性调节剂以及用于鉴定和使用这些调节剂的方法。

公开(公告)号：US4936582A

公开(公告)日：1990-06-26

申请号：US316138

申请日：1989-02-24

申请人： Kenneth Bernstein

发明人： Kenneth Bernstein

IPC分类号： A63B53/00

CPC分类号： A63B53/00 ,  A63B53/007 ,  Y10S273/08

摘要： This invention is comprised of a golf club molded in a single piece including grip, shaft and head, preferably in the form of a putter or a wedge or in an alternative embodiment a golf club employing a flexible plastic shaft with a conventional grip and club head. These clubs are molded out of rubber or a flexible plastic material with appropriate physical properties to approximate the appearance and feel of a conventional golf club. However, the characteristics of rubber or rubber like material permit the club to be bent, twisted or deformed by violent contact with the ground or other objects. The material of construction permits a club after such distortion to be returned to its initial shape. These characteristics are designed primarily to permit a frustrated golfer to vent his feelings of frustration or dissatisfaction in a way that is non-destructive of his equipment. The preferred material for the molded club or the shaft is either polyurethane of 75 durometer; Shore D rating or natural rubber of 70 durometer Shore A rating, each with 2000 psi tensile strength.

摘要翻译： 本发明包括一个模制成单件的高尔夫球杆，包括把手，轴和头部，优选地为推杆或楔块的形式，或者在替代实施例中，使用具有常规手柄和球杆头的柔性塑料轴的高尔夫球杆 。 这些俱乐部由具有适当物理性质的橡胶或柔性塑料材料成型，以接近常规高尔夫球杆的外观和感觉。 然而，橡胶或橡胶状材料的特性允许球杆与地面或其他物体剧烈接触而弯曲，扭曲或变形。 建筑材料允许俱乐部在这种变形之后恢复初始形状。 这些特征的设计主要是为了让沮丧的高尔夫球手以无损的设备的方式发泄沮丧或不满的感觉。 用于模制的球杆或轴的优选材料是75硬度的聚氨酯; 肖氏D级或天然橡胶，70硬度邵氏A等级，各自具有2000 psi拉伸强度。

公开(公告)号：USD678533S1

公开(公告)日：2013-03-19

申请号：US29413006

申请日：2012-02-09

申请人： Kenneth Bernstein

设计人： Kenneth Bernstein