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公开(公告)号：US08163958B2
公开(公告)日：2012-04-24
申请号：US13095101
申请日：2011-04-27
申请人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
发明人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
IPC分类号： C07C233/00 , C07C69/00
CPC分类号： C07C235/60 , C07C229/34 , C07C229/36 , C07C235/48 , C07C2601/14 , C07D213/79 , C07D213/80 , C07D213/803
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。
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公开(公告)号：US07601708B2
公开(公告)日：2009-10-13
申请号：US11183911
申请日：2005-07-19
申请人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
发明人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
CPC分类号： C07K5/0205 , A61K31/56 , A61K38/00 , A61K47/54 , A61K47/554 , A61K47/64 , A61K47/65 , C07C237/12 , C07C237/20 , C07C323/60 , C07C2601/14 , C07D207/16 , C07D233/64
摘要： This invention is directed to methods for providing sustained systemic concentrations of therapeutic or prophylactic agents such as GABA analogs following oral administration to animals. This invention is also directed to compounds and pharmaceutical compositions that are used in such methods.
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公开(公告)号：US20090137834A1
公开(公告)日：2009-05-28
申请号：US12364453
申请日：2009-02-02
申请人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
发明人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
IPC分类号： C07C227/14
CPC分类号： C07C235/60 , C07C229/34 , C07C229/36 , C07C235/48 , C07C2601/14 , C07D213/79 , C07D213/80 , C07D213/803
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。
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公开(公告)号：US07323585B2
公开(公告)日：2008-01-29
申请号：US11145280
申请日：2005-06-03
申请人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy
发明人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy
IPC分类号： C07C229/00 , A01N37/00
CPC分类号： C07C229/36
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
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公开(公告)号：US07049305B2
公开(公告)日：2006-05-23
申请号：US11053324
申请日：2005-02-09
申请人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
发明人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
CPC分类号： C07D233/64 , A61K38/00 , A61K47/554 , A61K47/64 , A61K47/65 , C07C237/12 , C07C237/20 , C07C323/60 , C07C2601/14 , C07D207/16 , C07K5/0205 , C07K5/06 , C07K5/08
摘要： This invention is directed to compounds that provide for sustained systemic concentrations of therapeutic or prophylactic agents following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
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公开(公告)号：US20110201817A1
公开(公告)日：2011-08-18
申请号：US13095101
申请日：2011-04-27
申请人： Jia-Ning XIANG , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
发明人： Jia-Ning XIANG , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
IPC分类号： C07C229/36 , C07D213/803
CPC分类号： C07C235/60 , C07C229/34 , C07C229/36 , C07C235/48 , C07C2601/14 , C07D213/79 , C07D213/80 , C07D213/803
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。
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公开(公告)号：US07671089B2
公开(公告)日：2010-03-02
申请号：US12001618
申请日：2007-12-11
申请人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
发明人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
IPC分类号： A61K31/24
CPC分类号： C07C229/36
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。
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8.发明授权公开(公告)号：US07601706B2
公开(公告)日：2009-10-13
申请号：US11388021
申请日：2006-03-24
申请人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
发明人： Kenneth C. Cundy , Mark A. Gallop , Cindy X. Zhou
CPC分类号： C07D233/64 , A61K38/00 , A61K47/554 , A61K47/64 , A61K47/65 , C07C237/12 , C07C237/20 , C07C323/60 , C07C2601/14 , C07D207/16 , C07K5/0205 , C07K5/06 , C07K5/08
摘要： This invention is directed to compounds that provide for sustained systemic concentrations of therapeutic or prophylactic agents following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
摘要翻译： 本发明涉及在给予动物后提供治疗性或预防性药物的持续全身浓度的化合物。 本发明还涉及药物组合物，包括使用这些化合物的方法。
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公开(公告)号：US07534813B2
公开(公告)日：2009-05-19
申请号：US12008473
申请日：2008-01-10
申请人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
发明人： Jia-Ning Xiang , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
CPC分类号： C07C235/60 , C07C229/34 , C07C229/36 , C07C235/48 , C07C2601/14 , C07D213/79 , C07D213/80 , C07D213/803
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译： 公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。
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10.发明授权公开(公告)号：US07101912B2
公开(公告)日：2006-09-05
申请号：US10728942
申请日：2003-12-08
申请人： Jia-Ning Xiang , Mark A. Gallop , Kenneth C. Cundy , Jianhua Li , Feng Xu , Cindy X. Zhou , Laxminarayan Bhat
发明人： Jia-Ning Xiang , Mark A. Gallop , Kenneth C. Cundy , Jianhua Li , Feng Xu , Cindy X. Zhou , Laxminarayan Bhat
IPC分类号： A61K31/216 , C07C229/28
CPC分类号： C07D213/30 , C07C243/18 , C07C281/02 , C07D295/088 , C07D307/89
摘要： Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed.
摘要翻译： 卡比多巴的前药，卡比多前药的衍生物，卡比多巴的前药及其衍生物的制备方法，卡比多巴的前药及其衍生物的使用方法，卡比多巴及其衍生物的前药组合物。
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