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207 条记录 (耗时 0.058 秒)

    AMINO ACID DERIVED PRODRUGS OF PROPOFOL, COMPOSITIONS, USES AND CRYSTALLINE FORMS THEREOF
    4.
    发明申请
    AMINO ACID DERIVED PRODRUGS OF PROPOFOL, COMPOSITIONS, USES AND CRYSTALLINE FORMS THEREOF 失效
    丙烯酸的丙烯酸衍生物，组合物，用途及其结晶形式

    公开(公告)号：US20100087536A1

    公开(公告)日：2010-04-08

    申请号：US12572505

    申请日：2009-10-02

    申请人： Feng Xu ,  Mark A. Gallop ,  Vivek Sasikumar ,  Usha Dilip

    发明人： Feng Xu ,  Mark A. Gallop ,  Vivek Sasikumar ,  Usha Dilip

    IPC分类号： A61K31/195 ,  A61P25/28 ,  A61P25/16 ,  A61P9/10 ,  A61P25/22 ,  A61P25/24

    CPC分类号： C07C229/22

    摘要： The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post-chemotherapy or post-operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.

    摘要翻译： 本发明提供异丙酚及其结晶形式的前药，制备异丙酚前药及其结晶形式的方法，异丙酚前药及其结晶形式的药物组合物，使用异丙酚前药及其结晶形式的方法及其药物组合物 治疗诸如头痛，化疗后或术后手术恶心和呕吐，神经变性障碍和情绪障碍的疾病或障碍。

    Amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof
    6.
    发明授权
    Amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof 失效
    丙泊酚的氨基酸衍生前药，组合物，用途及其结晶形式

    公开(公告)号：US08067455B2

    公开(公告)日：2011-11-29

    申请号：US12572505

    申请日：2009-10-02

    申请人： Feng Xu ,  Mark A. Gallop ,  Vivek Sasikumar ,  Usha Dilip

    发明人： Feng Xu ,  Mark A. Gallop ,  Vivek Sasikumar ,  Usha Dilip

    IPC分类号： A61K31/415

    CPC分类号： C07C229/22

    摘要： The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post-chemotherapy or post-operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.

    摘要翻译： 本发明提供异丙酚及其结晶形式的前药，制备异丙酚前药及其结晶形式的方法，异丙酚前药及其结晶形式的药物组合物，使用异丙酚前药及其结晶形式的方法及其药物组合物 治疗诸如头痛，化疗后或术后手术恶心和呕吐，神经变性障碍和情绪障碍的疾病或障碍。

    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    7.
    发明授权
    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 失效
    氨基甲酸氨基甲酸烷基酯前药，合成和使用方法

    公开(公告)号：US07749985B2

    公开(公告)日：2010-07-06

    申请号：US12506961

    申请日：2009-07-21

    申请人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    发明人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    IPC分类号： A61K31/66 ,  C07F9/02

    CPC分类号： C07F9/301

    摘要： Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

    摘要翻译： 3-氨基丙基次膦酸的氨基甲酸烷基酯氨基甲酸酯前药及其类似物，3-氨基丙基次膦酸及其类似物的制备酰氨基烷基氨基甲酸酯前药的方法及其类似物，使用3-氨基丙基次膦酸及其类似物的酰氨基烷基氨基甲酸酯前药的方法和包含酰氨基烷基氨基甲酸酯前药3 - 氨基丙基次膦酸及其类似物用于治疗疾病或病症如轻度认知障碍，与阿尔茨海默氏病相关的认知障碍阿尔茨海默氏病，抑郁症，焦虑和癫痫。 还公开了适用于口服给药和缓释口服剂型的3-氨基丙基次膦酸的氨基氧基烷基氨基甲酸酯前药及其类似物。

    Aromatic prodrugs of propofol, compositions and uses thereof
    9.
    发明授权
    Aromatic prodrugs of propofol, compositions and uses thereof 失效
    丙泊酚的芳族前药，其组合物和用途

    公开(公告)号：US07576127B2

    公开(公告)日：2009-08-18

    申请号：US11507968

    申请日：2006-08-21

    申请人： Mark A. Gallop ,  Feng Xu

    发明人： Mark A. Gallop ,  Feng Xu

    IPC分类号： A61K31/265 ,  A61K31/235

    CPC分类号： C07C271/28

    摘要： Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting are disclosed herein.

    摘要翻译： 丙泊酚的前药，制备丙泊酚前药的方法，丙泊酚前药的药物组合物和使用异丙酚前药的方法及其药物组合物治疗或预防疾病或病症如偏头痛头痛和化疗后或术后手术恶心 和呕吐。