公开(公告)号：US20050281758A1

公开(公告)日：2005-12-22

申请号：US10871659

申请日：2004-06-18

申请人： Kenneth Dodd ,  Ronald Gurge ,  David Tyndall

发明人： Kenneth Dodd ,  Ronald Gurge ,  David Tyndall

IPC分类号： A61C17/28 ,  A61C17/36 ,  A61K8/25 ,  A61K8/26 ,  A61K8/44 ,  A61K8/46 ,  A61K8/60 ,  A61K8/73 ,  A61K9/16 ,  A61Q11/00 ,  A61K7/20

CPC分类号： A61K8/26 ,  A61C17/28 ,  A61C17/36 ,  A61K8/731 ,  A61Q11/00

摘要： Oral care compositions are described herein. The oral care compositions generally have Theological properties that are desirable for use in a dispensing toothbrush. In some instances, the oral care composition has a yield point of y Pa and a shear slope of x Pa/Sec, wherein the ratio of yield point to shear slope is less than y/(74−370x+470x2). In some instances, the oral care composition has a Newtonian viscosity at 400 Pa of less than 1.0 Pa.s.

摘要翻译： 本文描述了口腔护理组合物。 口腔护理组合物通常具有用于分配牙刷中所需的神学性质。 在一些情况下，口腔护理组合物具有y Pa的屈服点和x Pa / Sec的剪切斜率，其中屈服点与剪切斜率的比值小于y /（74-370×+ 470×2 < / SUP>）。 在一些情况下，口腔护理组合物在400Pa下的牛顿粘度小于1.0Pa。

公开(公告)号：US20060018845A1

公开(公告)日：2006-01-26

申请号：US11057556

申请日：2005-02-14

申请人： Janette Edelstein ,  David Tyndall ,  Ronald Gurge ,  Rajeev Passi

发明人： Janette Edelstein ,  David Tyndall ,  Ronald Gurge ,  Rajeev Passi

IPC分类号： A61K8/73 ,  A61K8/22

CPC分类号： A61K8/0208 ,  A61K8/22 ,  A61K8/73 ,  A61K8/731 ,  A61Q11/00

摘要： Tooth whitening compositions, tooth whitening films, and methods of whitening teeth are described. The tooth whitening compositions and tooth whitening films include a tooth whitening agent and a cellulose polymer of formula (I) wherein; R is H, C1-6 alkyl, (C1-6 alkylO)mR2, or —C(O)R1, wherein at least one R is H, one R is C1-6 alkyl or (C1-6 alkylO)mR2, and one R is —C(O)R1; R1 is C5-10 aryl or C1-6 alkyl, optionally substituted with at least one CO2H; R2 is H or C(O)R1; m is 1-5; and n is 2-350. The tooth whitening compositions are may be, for example, liquids or films that are applied to a tooth for a time sufficient to whiten the tooth.

摘要翻译： 描述了牙齿美白组合物，牙齿美白膜和牙齿美白方法。 牙齿美白组合物和牙齿增白膜包括牙齿增白剂和式（I）的纤维素聚合物，其中： R为H，C 1-6烷基，（C 1-6烷基O）2 R 2，或 -C（O）R 1，其中至少一个R是H，一个R是C 1-6烷基或（C 1-6） > - >烷基O），其中R 1是-C（O）R 1; R 1是C 5〜5〜10个芳基或C 1-6烷基，任选被至少一个CO 2取代 > H; R 2是H或C（O）R 1; m为1-5; n为2-350。 牙齿美白组合物可以是例如施加到牙齿足以使牙齿变白的时间的液体或薄膜。

公开(公告)号：US20070154402A1

公开(公告)日：2007-07-05

申请号：US11552457

申请日：2006-10-24

申请人： Mark Trumbore ,  Ronald Gurge ,  Jane Hirsh

发明人： Mark Trumbore ,  Ronald Gurge ,  Jane Hirsh

IPC分类号： A61K38/46 ,  A61K9/12 ,  A61K31/19 ,  A61K31/203 ,  A61K36/18 ,  A61K31/17

CPC分类号： A61K9/122 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/12 ,  A61K9/124 ,  A61K31/17 ,  A61K31/19 ,  A61K31/203 ,  A61K38/4873 ,  A61K45/06 ,  A61K47/18 ,  C12Y304/22002 ,  A61K2300/00

摘要： A stable topical alcohol-free aerosol foam containing one or more keratolytic agents is provided. The foam-forming formulation is an emulsion which contains an HFA propellant and one or more keratolytic agents. The emulsion has an oil phase and an aqueous, i.e. water-containing, phase. The active agent(s) may be present in either phase of the emulsion or dispersed in the emulsion. The oil phase may consist at least in part of the HFA propellant. Either or both of the oil phase and the aqueous phase may contain one or more surfactants, emulsifiers, emulsion stabilizers, buffers, and/or other excipients. The foam is stable on the skin, for example, for at least 5 minutes at body temperature, preferably at least 20 minutes at body temperature, and disappears into the skin upon rubbing or after prolonged standing. In one embodiment, the formulation contains an HFA propellant which does not contain additional co-solvents or co-propellants. The formulations demonstrate reduced intensity of the odor and/or color associated with the keratolytic agent(s) as compared to conventional formulations containing keratolytic agents.

摘要翻译： 提供了含有一种或多种角质分解剂的稳定的局部无酒精气溶胶泡沫体。 泡沫形成制剂是含有HFA推进剂和一种或多种角质分解剂的乳液。 乳液具有油相和含水相，即含水相。 活性剂可以存在于乳液的任一相中或分散在乳液中。 油相可以至少部分地由HFA推进剂组成。 油相和水相中的任一种或两者可以含有一种或多种表面活性剂，乳化剂，乳液稳定剂，缓冲剂和/或其它赋形剂。 泡沫在皮肤上是稳定的，例如在体温下至少5分钟，优选在体温至少20分钟，并且在摩擦或长时间放置后消失在皮肤中。 在一个实施方案中，制剂含有不含额外的共溶剂或共推进剂的HFA推进剂。 与含有角质分解剂的常规制剂相比，该配方表现出与角质分解剂相关的气味和/或颜色的强度降低。

公开(公告)号：US20070036731A1

公开(公告)日：2007-02-15

申请号：US11464100

申请日：2006-08-11

申请人： Jane Hirsh ,  Ronald Gurge ,  Mark Hirsh ,  Mark Trumbore

发明人： Jane Hirsh ,  Ronald Gurge ,  Mark Hirsh ,  Mark Trumbore

IPC分类号： A61K31/7034 ,  A61K9/14 ,  A61K31/496 ,  A61K31/4178 ,  A61K31/4196

CPC分类号： A61K47/34 ,  A61K9/0014 ,  A61K9/12 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/7034 ,  A61K47/02

摘要： Aerosol spray formulations capable of delivering high concentrations of active agent-containing materials and/or excipient are described herein. The formulation contains a carrier fluid, a propellant, and a therapeutic, prophylactic, consmeticeutical and/or inert solid suspended, dissolved, or dispersed in the formulation. The active ingredient may be any pharmaceutically active agent, but is preferably an antibiotic, an antihistamine, an anesthetic, an anti-inflammatory, and/or an astringent. In one embodiment, the active agent is an antifungal agent. In another embodiment, the active agent is a consmeticeutical. The active agent can optionally be dispersed on, or associated with, a carrier powder. The carrier fluid is a highly volatile silicone liquid, which evaporates in less than 10 minutes, preferably less than 5 minutes, after application of the formulation to the patient's skin. The formulation may also contain one or more pharmaceutically acceptable excipients such as antioxidants, stabilizers, perfumes, colorants, viscosifiers, emulsifiers, surfactants, and combinations thereof. The formulation can be packaged in a conventional aerosol spray can.

摘要翻译： 本文描述了能够递送高浓度的含活性剂的物质和/或赋形剂的气溶胶喷雾制剂。 制剂含有悬浮，溶解或分散在制剂中的载体流体，推进剂和治疗性，预防性，依赖性和/或惰性固体。 活性成分可以是任何药物活性剂，但优选为抗生素，抗组胺剂，麻醉剂，抗炎剂和/或收敛剂。 在一个实施方案中，活性剂是抗真菌剂。 在另一个实施方案中，活性剂是一种辅助药。 活性剂可以任选地分散在载体粉末上或与载体粉末相关联。 载体流体是高度挥发性的有机硅液体，其在将制剂施用于患者皮肤后在少于10分钟，优选少于5分钟内蒸发。 制剂还可以含有一种或多种药学上可接受的赋形剂，例如抗氧化剂，稳定剂，香料，着色剂，增粘剂，乳化剂，表面活性剂及其组合。 该制剂可以包装在常规的气溶胶喷雾罐中。