公开(公告)号：US20070036731A1

公开(公告)日：2007-02-15

申请号：US11464100

申请日：2006-08-11

申请人： Jane Hirsh ,  Ronald Gurge ,  Mark Hirsh ,  Mark Trumbore

发明人： Jane Hirsh ,  Ronald Gurge ,  Mark Hirsh ,  Mark Trumbore

IPC分类号： A61K31/7034 ,  A61K9/14 ,  A61K31/496 ,  A61K31/4178 ,  A61K31/4196

CPC分类号： A61K47/34 ,  A61K9/0014 ,  A61K9/12 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/7034 ,  A61K47/02

摘要： Aerosol spray formulations capable of delivering high concentrations of active agent-containing materials and/or excipient are described herein. The formulation contains a carrier fluid, a propellant, and a therapeutic, prophylactic, consmeticeutical and/or inert solid suspended, dissolved, or dispersed in the formulation. The active ingredient may be any pharmaceutically active agent, but is preferably an antibiotic, an antihistamine, an anesthetic, an anti-inflammatory, and/or an astringent. In one embodiment, the active agent is an antifungal agent. In another embodiment, the active agent is a consmeticeutical. The active agent can optionally be dispersed on, or associated with, a carrier powder. The carrier fluid is a highly volatile silicone liquid, which evaporates in less than 10 minutes, preferably less than 5 minutes, after application of the formulation to the patient's skin. The formulation may also contain one or more pharmaceutically acceptable excipients such as antioxidants, stabilizers, perfumes, colorants, viscosifiers, emulsifiers, surfactants, and combinations thereof. The formulation can be packaged in a conventional aerosol spray can.

摘要翻译： 本文描述了能够递送高浓度的含活性剂的物质和/或赋形剂的气溶胶喷雾制剂。 制剂含有悬浮，溶解或分散在制剂中的载体流体，推进剂和治疗性，预防性，依赖性和/或惰性固体。 活性成分可以是任何药物活性剂，但优选为抗生素，抗组胺剂，麻醉剂，抗炎剂和/或收敛剂。 在一个实施方案中，活性剂是抗真菌剂。 在另一个实施方案中，活性剂是一种辅助药。 活性剂可以任选地分散在载体粉末上或与载体粉末相关联。 载体流体是高度挥发性的有机硅液体，其在将制剂施用于患者皮肤后在少于10分钟，优选少于5分钟内蒸发。 制剂还可以含有一种或多种药学上可接受的赋形剂，例如抗氧化剂，稳定剂，香料，着色剂，增粘剂，乳化剂，表面活性剂及其组合。 该制剂可以包装在常规的气溶胶喷雾罐中。

公开(公告)号：US20070154402A1

公开(公告)日：2007-07-05

申请号：US11552457

申请日：2006-10-24

申请人： Mark Trumbore ,  Ronald Gurge ,  Jane Hirsh

发明人： Mark Trumbore ,  Ronald Gurge ,  Jane Hirsh

IPC分类号： A61K38/46 ,  A61K9/12 ,  A61K31/19 ,  A61K31/203 ,  A61K36/18 ,  A61K31/17

CPC分类号： A61K9/122 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/12 ,  A61K9/124 ,  A61K31/17 ,  A61K31/19 ,  A61K31/203 ,  A61K38/4873 ,  A61K45/06 ,  A61K47/18 ,  C12Y304/22002 ,  A61K2300/00

摘要： A stable topical alcohol-free aerosol foam containing one or more keratolytic agents is provided. The foam-forming formulation is an emulsion which contains an HFA propellant and one or more keratolytic agents. The emulsion has an oil phase and an aqueous, i.e. water-containing, phase. The active agent(s) may be present in either phase of the emulsion or dispersed in the emulsion. The oil phase may consist at least in part of the HFA propellant. Either or both of the oil phase and the aqueous phase may contain one or more surfactants, emulsifiers, emulsion stabilizers, buffers, and/or other excipients. The foam is stable on the skin, for example, for at least 5 minutes at body temperature, preferably at least 20 minutes at body temperature, and disappears into the skin upon rubbing or after prolonged standing. In one embodiment, the formulation contains an HFA propellant which does not contain additional co-solvents or co-propellants. The formulations demonstrate reduced intensity of the odor and/or color associated with the keratolytic agent(s) as compared to conventional formulations containing keratolytic agents.

摘要翻译： 提供了含有一种或多种角质分解剂的稳定的局部无酒精气溶胶泡沫体。 泡沫形成制剂是含有HFA推进剂和一种或多种角质分解剂的乳液。 乳液具有油相和含水相，即含水相。 活性剂可以存在于乳液的任一相中或分散在乳液中。 油相可以至少部分地由HFA推进剂组成。 油相和水相中的任一种或两者可以含有一种或多种表面活性剂，乳化剂，乳液稳定剂，缓冲剂和/或其它赋形剂。 泡沫在皮肤上是稳定的，例如在体温下至少5分钟，优选在体温至少20分钟，并且在摩擦或长时间放置后消失在皮肤中。 在一个实施方案中，制剂含有不含额外的共溶剂或共推进剂的HFA推进剂。 与含有角质分解剂的常规制剂相比，该配方表现出与角质分解剂相关的气味和/或颜色的强度降低。

公开(公告)号：US20050281806A1

公开(公告)日：2005-12-22

申请号：US11147567

申请日：2005-06-08

申请人： Mark Trumbore ,  Roman Rariy ,  Mark Hirsh ,  Jane Hirsh ,  Julie Saunders

发明人： Mark Trumbore ,  Roman Rariy ,  Mark Hirsh ,  Jane Hirsh ,  Julie Saunders

IPC分类号： A61K9/00 ,  A61K9/12 ,  A61K33/18 ,  A61K33/36 ,  A61K33/38 ,  A61K36/48 ,  A61K38/46 ,  A61K38/48 ,  A61K47/44 ,  A61K35/78

CPC分类号： A61K9/0014 ,  A61K9/12 ,  A61K33/18 ,  A61K33/38 ,  A61K36/48 ,  A61K38/482 ,  A61K38/4826 ,  A61K38/4873 ,  A61K38/4886 ,  A61K47/44 ,  A61L15/34 ,  A61L15/38 ,  A61L15/48 ,  A61K2300/00

摘要： Formulations are described for the treatment by enzymatic debridement of wounds and ulcers. The formulations have a clear, transparent composition that allows for easy visualization of the wound, and are non-staining for easy clean up. These formulations can also exhibit increased enzymatic debridement activity, improved post-treatment lubricity and coating occlusivity, and stability. The formulations, optionally containing non-animal source biologics, may be in the form of lotions, aerosols to provide a spray, or a foam. A non-reactive substrate may be used as a composition carrier. A non-aqueous lotion formulation having improved enzymatic activity is provided. The non-aqueous lotion viscosity is adjusted to achieve high enzymatic activity while maintaining the application benefits of high viscosity non-aqueous lotions. The lotion formulation may be delivered in a patch.

摘要翻译： 描述了用于通过创伤和溃疡的酶清除治疗的制剂。 制剂具有清晰，透明的组合物，其允许容易地观察伤口，并且是无污染的以便于清洁。 这些制剂还可以表现出增加的酶清除活性，改善的后处理润滑性和涂层封闭性以及稳定性。 任选地含有非动物源生物制剂的制剂可以是洗剂，提供喷雾剂或泡沫剂的气溶胶的形式。 非反应性底物可以用作组合物载体。 提供了具有改善的酶活性的非水性乳液制剂。 调节非水性乳液粘度以达到高酶活性，同时保持高粘度非水性乳液的应用益处。 洗剂制剂可以在贴剂中递送。

公开(公告)号：US20070232695A1

公开(公告)日：2007-10-04

申请号：US11534552

申请日：2006-09-22

申请人： Mark Hirsh ,  Jane Hirsh ,  Mark Trumbore

发明人： Mark Hirsh ,  Jane Hirsh ,  Mark Trumbore

IPC分类号： A61K31/325

CPC分类号： A61K31/325 ,  A61K9/006 ,  A61K9/0063 ,  A61K31/245 ,  A61K45/06 ,  A61K2300/00

摘要： A composition for anesthetizing oral or buccal tissues, especially periodontal pockets, is provided. The composition has a high concentration of topical anesthetic carried in a non-aqueous liquid vehicle containing a gelling agent. The anesthetics are optionally stabilized in the solution by ion-exchange complexation. The composition can anesthetize the gingivae for an extended period, such as 30 minutes or longer. Preferred anesthetics include tetracaine, benzocaine, butamben, and mixtures of these.

摘要翻译： 提供了用于麻醉口腔或颊组织，特别是牙周袋的组合物。 该组合物在含有胶凝剂的非水液体载体中携带高浓度的局部麻醉剂。 麻醉剂任选地通过离子交换络合稳定在溶液中。 组合物可以长时间麻醉牙龈，例如30分钟或更长时间。 优选的麻醉剂包括丁卡因，苯佐卡因，丁苯丁酸及其混合物。

公开(公告)号：US20050255048A1

公开(公告)日：2005-11-17

申请号：US11128947

申请日：2005-05-13

申请人： Mark Hirsh ,  Jane Hirsh ,  Ira Skolnik ,  Mark Trumbore

发明人： Mark Hirsh ,  Jane Hirsh ,  Ira Skolnik ,  Mark Trumbore

IPC分类号： A61K9/12 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/58 ,  A61K31/65 ,  A61K31/704 ,  A61K31/7048

CPC分类号： A61K31/58 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/122 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/65 ,  A61K31/704 ,  A61K31/7048 ,  A61K45/06 ,  A61K2300/00

摘要： A topical spray or foam, methods of making the formulation, and methods of use thereof, has been developed. In one preferred embodiment, the composition includes one or more active agents and exhibits both antibacterial activity and antifungal activity. Excipients such as chemical disinfectants, anti-pruritic agents to minimize itching, and skin protective compounds may be added. The composition may be formulated to be dispensed as a spray or foam and the spray or foam may be administered either by a hand pump or by an aerosolizing propellant. A second single phase formulation has also been developed. The formulation comprises a first drug which is water soluble or hydrophilic and a second drug which is lipid soluble or hydrophobic, wherein at least one of the drugs is bound to an ion-exchange resin. The use of binding resins, such as ion-exchange resins, allows drugs with incompatible solvent requirements to be prepared in a single-phase formulation.

摘要翻译： 已经开发了局部喷雾或泡沫，制备方法及其使用方法。 在一个优选的实施方案中，组合物包含一种或多种活性剂并且表现出抗菌活性和抗真菌活性。 可以加入赋形剂如化学消毒剂，抗瘙痒剂以最小化瘙痒和皮肤保护性化合物。 组合物可以配制成以喷雾或泡沫的形式分配，并且喷雾或泡沫可以通过手泵或雾化推进剂施用。 还开发了第二个单相制剂。 该制剂包含水溶性或亲水性的第一药物和脂溶性或疏水性的第二药物，其中至少一种药物与离子交换树脂结合。 使用结合树脂，例如离子交换树脂，可以在单相制剂中制备具有不相容溶剂要求的药物。

公开(公告)号：US20090010869A9

公开(公告)日：2009-01-08

申请号：US11843158

申请日：2007-08-22

申请人： Mark Trumbore ,  Roman Rariy ,  Mark Hirsh ,  Jane Hirsh ,  Julie Saunders

发明人： Mark Trumbore ,  Roman Rariy ,  Mark Hirsh ,  Jane Hirsh ,  Julie Saunders

IPC分类号： A61K31/74 ,  A61K33/38 ,  A61K35/00 ,  A61K38/43 ,  A61P17/00

CPC分类号： A61K9/0014 ,  A61K9/12 ,  A61K33/18 ,  A61K33/38 ,  A61K36/48 ,  A61K38/482 ,  A61K38/4826 ,  A61K38/4873 ,  A61K38/4886 ,  A61K47/44 ,  A61L15/34 ,  A61L15/38 ,  A61L15/48 ,  A61K2300/00

摘要： Formulations are described for the treatment by enzymatic debridement of wounds and ulcers. The formulations have a clear, transparent composition that allows for easy visualization of the wound, and are non-staining for easy clean up. These formulations can also exhibit increased enzymatic debridement activity, improved post-treatment lubricity and coating occlusivity, and stability. The formulations, optionally containing non-animal source biologics, may be in the form of lotions, aerosols to provide a spray, or a foam. A non-reactive substrate may be used as a composition carrier. A non-aqueous lotion formulation having improved enzymatic activity is provided. The non-aqueous lotion viscosity is adjusted to achieve high enzymatic activity while maintaining the application benefits of high viscosity non-aqueous lotions. The lotion formulation may be delivered in a patch.

摘要翻译： 描述了用于通过创伤和溃疡的酶清除治疗的制剂。 制剂具有清晰，透明的组合物，其允许容易地观察伤口，并且是无污染的以便于清洁。 这些制剂还可以表现出增加的酶清除活性，改善的后处理润滑性和涂层封闭性以及稳定性。 任选地含有非动物源生物制剂的制剂可以是洗剂，提供喷雾剂或泡沫剂的气溶胶的形式。 非反应性底物可以用作组合物载体。 提供了具有改善的酶活性的非水性乳液制剂。 调节非水性乳液粘度以达到高酶活性，同时保持高粘度非水性乳液的应用益处。 洗剂制剂可以在贴剂中递送。

公开(公告)号：US20080014169A1

公开(公告)日：2008-01-17

申请号：US11843158

申请日：2007-08-22

申请人： Mark Trumbore ,  Roman Rariy ,  Mark Hirsh ,  Jane Hirsh ,  Julie Saunders

发明人： Mark Trumbore ,  Roman Rariy ,  Mark Hirsh ,  Jane Hirsh ,  Julie Saunders

IPC分类号： A61K31/74 ,  A61K33/38 ,  A61K35/00 ,  A61K38/43 ,  A61P17/00

CPC分类号： A61K9/0014 ,  A61K9/12 ,  A61K33/18 ,  A61K33/38 ,  A61K36/48 ,  A61K38/482 ,  A61K38/4826 ,  A61K38/4873 ,  A61K38/4886 ,  A61K47/44 ,  A61L15/34 ,  A61L15/38 ,  A61L15/48 ,  A61K2300/00

摘要： Formulations are described for the treatment by enzymatic debridement of wounds and ulcers. The formulations have a clear, transparent composition that allows for easy visualization of the wound, and are non-staining for easy clean up. These formulations can also exhibit increased enzymatic debridement activity, improved post-treatment lubricity and coating occlusivity, and stability. The formulations, optionally containing non-animal source biologics, may be in the form of lotions, aerosols to provide a spray, or a foam. A non-reactive substrate may be used as a composition carrier. A non-aqueous lotion formulation having improved enzymatic activity is provided. The non-aqueous lotion viscosity is adjusted to achieve high enzymatic activity while maintaining the application benefits of high viscosity non-aqueous lotions. The lotion formulation may be delivered in a patch.

摘要翻译： 描述了用于通过创伤和溃疡的酶清除治疗的制剂。 制剂具有清晰，透明的组合物，其允许容易地观察伤口，并且是无污染的以便于清洁。 这些制剂还可以表现出增加的酶清除活性，改善的后处理润滑性和涂层封闭性以及稳定性。 任选地含有非动物源生物制剂的制剂可以是洗剂，提供喷雾剂或泡沫剂的气溶胶的形式。 非反应性底物可以用作组合物载体。 提供了具有改善的酶活性的非水性乳液制剂。 调节非水性乳液粘度以达到高酶活性，同时保持高粘度非水性乳液的应用益处。 洗剂制剂可以在贴剂中递送。

公开(公告)号：US20070036843A1

公开(公告)日：2007-02-15

申请号：US11341016

申请日：2006-01-27

申请人： Jane Hirsh ,  Roman Rariy ,  Mark Trumbore ,  Alison Fleming ,  Mark Hirsh

发明人： Jane Hirsh ,  Roman Rariy ,  Mark Trumbore ,  Alison Fleming ,  Mark Hirsh

IPC分类号： A61K9/70 ,  A61K9/22

CPC分类号： A61K31/4402 ,  A61K9/006 ,  A61K9/5026 ,  A61K31/137 ,  A61K47/585

摘要： An improved controlled release composition for non-parenteral administration of active agents and other therapeutics, particularly for oral or topical administration, has been developed. The composition is made by dispersing a complex formed of an active agent bound to an ion-exchange resin or to another form of resin or carrier, in a non-ionic non-aqueous (“NINA”) vehicle. The complexes are optionally coated with one or more layers of coating material to provide a controlled pattern of release of active agent from the carrier. Replacing the usual aqueous vehicle with a NINA vehicle, such as an oil or an ointment, allows the active agent-carrier complexes, with or without coatings, to be both orally and topically administered. The compositions can be formulated as powders, liquids, liquid suspensions, gels, capsules, soft gelatin capsules, tablets, chewable tablets, topical ointments, lotions, pourable or pumpable fluids, semisolid, crushable tablets, and unit-of-use sachets or capsules for reconstitution or direct application. The combination of multiple active agents is possible with this system, in which one or more active agents are bound to particles and one or more active agents are dissolved or dispersed in the NINA vehicle. This allows the combination of two or more active agents, which are otherwise incompatible, into a single dosage form.

摘要翻译： 已经开发了用于非肠胃外给药活性剂和其它治疗剂，特别是用于口服或局部给药的改进的控释组合物。 该组合物通过在非离子非水（“NINA”）载体中分散由与离子交换树脂结合的活性剂形成的络合物或另一种形式的树脂或载体。 复合物任选地涂覆有一层或多层涂层材料，以提供活性剂从载体中释放的受控模式。 用诸如油或软膏的NINA载体代替普通的水性载体，允许具有或不具有涂层的活性剂 - 载体复合物均经口和局部施用。 组合物可以配制成粉末，液体，液体悬浮液，凝胶，胶囊，软明胶胶囊，片剂，咀嚼片，局部软膏，洗剂，可倾倒或可泵送的液体，半固体，可压碎片剂和单位使用的小袋或胶囊 用于重组或直接应用。 该系统可以使用多种活性剂的组合，其中一种或多种活性剂与颗粒结合，一种或多种活性剂溶解或分散在NINA载体中。 这允许将两种或更多种否则不相容的活性剂组合成单一剂型。

公开(公告)号：US20060134048A1

公开(公告)日：2006-06-22

申请号：US11313986

申请日：2005-12-21

申请人： Douglas Shander ,  James Henry ,  Hsing-Mei Wu ,  Natalia Botchkareva ,  Gurpreet Ahluwalia ,  Mark Trumbore

发明人： Douglas Shander ,  James Henry ,  Hsing-Mei Wu ,  Natalia Botchkareva ,  Gurpreet Ahluwalia ,  Mark Trumbore

IPC分类号： A61K48/00 ,  A61K8/73

CPC分类号： A61K9/0014 ,  A61K8/49 ,  A61K8/4906 ,  A61K8/73 ,  A61K2800/242 ,  A61Q7/02

摘要： A method of reducing hair growth includes topical application of a heat shock protein inhibitor and/or a compound that promotes apoptosis in conjunction with heat.

摘要翻译： 减少毛发生长的方法包括局部施用热休克蛋白抑制剂和/或促进与热结合的凋亡的化合物。