公开(公告)号：US08585771B2

公开(公告)日：2013-11-19

申请号：US11807107

申请日：2007-05-25

申请人： Kenneth F. Binmoeller ,  Matthew Yurek ,  Zhenyong Keck ,  James T. McKinley

发明人： Kenneth F. Binmoeller ,  Matthew Yurek ,  Zhenyong Keck ,  James T. McKinley

IPC分类号： A61F2/04

CPC分类号： A61F5/0076 ,  A61F2002/044 ,  A61F2002/045 ,  A61F2210/0014 ,  A61N1/36007

摘要： The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and/or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.

摘要翻译： 本发明涉及操作有助于抑制食欲和/或减少食物摄取的装置的装置和方法。 在一些实施方案中，本发明的方法和装置包括肠/十二指肠插入物，其包含具有至少一个流动减少元件的细长构件，其可以引起一种或多种饱腹感的生物学信号的刺激。 插入的装置的一些实施例通过驻留在胃中的锚固构件锚定在十二指肠部位，装置的其它实施例通过适当的长度尺寸以及对应的装置的一个或多个成角度的部分而被稳定在目标部位 到达目标地点的角部分。 该装置的实施方案由于物理存在以及通过更积极的干预形式（包括释放生物活性物质和电刺激神经元）而发挥作用。

公开(公告)号：US20110137227A1

公开(公告)日：2011-06-09

申请号：US12999180

申请日：2009-07-02

申请人： James T. McKinley ,  Zhenyong Keck ,  Fiona M. Sander

发明人： James T. McKinley ,  Zhenyong Keck ,  Fiona M. Sander

IPC分类号： A61F2/04

CPC分类号： A61F5/0079 ,  A61M27/002

摘要： Devices are described that are adapted and configured for use within the duodenum of a mammal. One aspect of the device includes a spine having a proximal end and a distal end; an atraumatic feature positioned on at least one of the proximal end and the distal end of the spine; and a flow reduction element positioned along the spine and having a variable porosity along its length. In another aspect, there is a flow reduction device adapted and configured for use within the duodenum of a mammal having a spine having a length, a proximal end and a distal end; a first atraumatic feature positioned adjacent to the spine proximal end; a second atraumatic feature positioned adjacent to the spine distal end wherein the length of the spine is selected so that when the first atraumatic feature is in the stomach the second atraumatic feature is in the fourth portion of the duodenum; and a flow reduction element having a proximal end, a distal end, an interior portion, an exterior portion and a variable porosity between the proximal end and the distal end. Additionally or alternatively, some or all of the components of the device may be formed from or coated with a lipid-philic material. There is also provided a method for adjusting the passage of ingesta through the duodenum of a mammal. The method includes placing the distal end of a flow reduction device in the duodenum of a mammal; placing the proximal end of the flow reduction device in a stomach of the mammal; expanding within the duodenum of the mammal a variable porosity flow reduction element supported by the flow reduction device; and directing at least a portion of the flow of ingesta through the duodenum through the proximal end of the variable porosity flow reduction element and into an interior portion of the variable porosity flow reduction element.

摘要翻译： 描述适于和配置用于哺乳动物十二指肠内的装置。 该装置的一个方面包括具有近端和远端的脊柱; 位于脊柱的近端和远端中的至少一个上的无创伤特征; 以及沿着脊柱定位的沿着其长度具有可变孔隙率的流动减少元件。 在另一方面，存在一种适于和构造用于具有脊柱的哺乳动物十二指肠内的流动减少装置，其具有长度，近端和远端; 邻近脊柱近端定位的第一无创伤特征; 第二无创伤特征位于脊柱远端附近，其中脊柱的长度被选择为使得当第一无创伤特征在胃中时，第二无创伤特征位于十二指肠的第四部分中; 以及流动减少元件，其具有近端，远端，内部部分，外部部分和近端和远端之间的可变孔隙率。 另外或替代地，装置的部分或全部组分可以由亲脂材料形成或涂覆有脂质材料。 还提供了一种用于调节通过哺乳动物十二指肠的食入通道的方法。 该方法包括将流量减少装置的远端放置在哺乳动物的十二指肠中; 将所述减流装置的近端放置在哺乳动物的胃中; 在哺乳动物的十二指肠内扩张由流量减小装置支撑的可变孔隙度流减少元件; 并且通过可变孔隙度流减少元件的近端引导摄食流的至少一部分通过十二指肠并进入可变孔隙度流减少元件的内部。

公开(公告)号：US20060188511A1

公开(公告)日：2006-08-24

申请号：US10958624

申请日：2004-10-05

申请人： Steven Foung ,  Kenneth Hadlock ,  Zhenyong Keck

发明人： Steven Foung ,  Kenneth Hadlock ,  Zhenyong Keck

IPC分类号： A61K39/42

CPC分类号： C07K16/109 ,  A61K39/42 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  A61K2300/00

摘要： Conformational epitopes of the envelope proteins E1 and E2 of the Hepatitis C virus (HCV) have been identified and characterized using a panel of monoclonal antibodies derived from patients infected with HCV. These conserved conformational and linear epitopes of the HCV protein E1 or E2 have been determined to be important in the immune response of humans to HCV and may be particularly important in neutralizing the virus. Based on the identification of these conformational epitopes, vaccines containing peptides and mimotopes with these conformational epitopes intact may be prepared and administered to patients to prevent and/or treat HCV infection. The identification of four distinct groups of monoclonal antibodies with each directed to a particular epitope of E1 or E2 may be used to stratify patients based on their response to HCV and may be used to determine a proper treatment regimen. Pharmaceutical compositions for prevention and treatment of HCV, comprising one or more the monoclonal antibodies, are provided.

摘要翻译： 已经使用来自感染HCV的患者的一组单克隆抗体鉴定和表征丙型肝炎病毒（HCV）的包膜蛋白E1和E2的构象表位。 已经确定HCV蛋白E1或E2的这些保守的构象和线性表位在人类对HCV的免疫应答中是重要的，并且在中和病毒时尤其重要。 基于这些构象表位的鉴定，可以制备含有具有这些构象表位的肽和模拟表位的疫苗，并将其施用于患者以预防和/或治疗HCV感染。 鉴定四种不同组的单克隆抗体，每种单克隆抗体针对E1或E2的特定表位可用于基于其对HCV的反应来对患者进行分层，并且可用于确定适当的治疗方案。 提供了包含一种或多种单克隆抗体的用于预防和治疗HCV的药物组合物。