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公开(公告)号：US08585771B2
公开(公告)日：2013-11-19
申请号：US11807107
申请日：2007-05-25
IPC分类号： A61F2/04
CPC分类号： A61F5/0076 , A61F2002/044 , A61F2002/045 , A61F2210/0014 , A61N1/36007
摘要： The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and/or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.
摘要翻译： 本发明涉及操作有助于抑制食欲和/或减少食物摄取的装置的装置和方法。 在一些实施方案中，本发明的方法和装置包括肠/十二指肠插入物，其包含具有至少一个流动减少元件的细长构件，其可以引起一种或多种饱腹感的生物学信号的刺激。 插入的装置的一些实施例通过驻留在胃中的锚固构件锚定在十二指肠部位，装置的其它实施例通过适当的长度尺寸以及对应的装置的一个或多个成角度的部分而被稳定在目标部位 到达目标地点的角部分。 该装置的实施方案由于物理存在以及通过更积极的干预形式（包括释放生物活性物质和电刺激神经元）而发挥作用。
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2.发明申请公开(公告)号：US20090187206A1
公开(公告)日：2009-07-23
申请号：US12174337
申请日：2008-07-16
IPC分类号： A61M29/00
CPC分类号： A61F5/0036 , A61F5/0013 , A61F5/003 , A61F5/0076 , A61F2002/044 , A61F2002/045 , A61F2210/0014 , A61F2210/0019 , A61F2210/009
摘要： The invention relates to devices that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and/or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.
摘要翻译： 本发明涉及通过其构象（包括长度和曲率的尺寸）稳定在胃肠道内腔内停留部位的装置。 整个装置对应于居住地点的构造; 更具体地，弯曲或成角度的部分对应于居住部位的弯曲或成角度部分，并且不符合直接近端或远端部位。 在一些实施例中，构象稳定的装置可以影响驻留位置形状的变化，这有助于装置的稳定性。 一些实施例旨在限制食欲和/或减少食物摄取，其他实施方案可以针对其他治疗目的。 设备的一些实施例被设计为完全驻留在十二指肠中; 其他的主要存在于十二指肠内，但是向近端延伸到胃窦内，而其它实施例被设计为驻留在胃肠道内的其他地方。
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3.发明授权公开(公告)号：US09060835B2
公开(公告)日：2015-06-23
申请号：US12174337
申请日：2008-07-16
CPC分类号： A61F5/0036 , A61F5/0013 , A61F5/003 , A61F5/0076 , A61F2002/044 , A61F2002/045 , A61F2210/0014 , A61F2210/0019 , A61F2210/009
摘要： The invention relates to devices that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and/or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.
摘要翻译： 本发明涉及通过其构象（包括长度和曲率的尺寸）稳定在胃肠道内腔内停留部位的装置。 整个装置对应于居住地点的构造; 更具体地，弯曲或成角度的部分对应于居住部位的弯曲或成角度部分，并且不符合直接近端或远端部位。 在一些实施例中，构象稳定的装置可以影响驻留位置形状的变化，这有助于装置的稳定性。 一些实施例旨在限制食欲和/或减少食物摄取，其他实施方案可以针对其他治疗目的。 设备的一些实施例被设计为完全驻留在十二指肠中; 其他的主要存在于十二指肠内，但是向近端延伸到胃窦内，而其它实施例被设计为驻留在胃肠道内的其他地方。
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公开(公告)号：US08454632B2
公开(公告)日：2013-06-04
申请号：US12427215
申请日：2009-04-21
IPC分类号： A61B17/08
CPC分类号： A61B17/12009 , A61B17/11 , A61B17/1114 , A61B17/3468 , A61B17/3478 , A61B2017/00278 , A61B2017/0034 , A61B2017/1139 , A61B2017/3486 , A61F2/82 , A61M25/1002 , A61M2025/0096 , A61M2025/09125 , A61M2025/1059
摘要： Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.
摘要翻译： 组织锚固件包括编织长丝编织体，其具有细长的管状构造和缩短构型，其中主体的近端和远端径向扩展成双壁凸缘结构，同时在其间留下圆柱形鞍形区域。 组织锚固件通过相邻组织层之间的穿透进行展开，其中凸缘接合组织层的外表面，并且鞍形区域位于组织穿透之内。
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公开(公告)号：US20130253546A1
公开(公告)日：2013-09-26
申请号：US13892958
申请日：2013-05-13
IPC分类号： A61B17/12
CPC分类号： A61B17/12009 , A61B17/11 , A61B17/1114 , A61B17/3468 , A61B17/3478 , A61B2017/00278 , A61B2017/0034 , A61B2017/1139 , A61B2017/3486 , A61F2/82 , A61M25/1002 , A61M2025/0096 , A61M2025/09125 , A61M2025/1059
摘要： Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.
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6.发明授权公开(公告)号：US09144428B2
公开(公告)日：2015-09-29
申请号：US12913469
申请日：2010-10-27
IPC分类号： A61B17/10 , A61B17/12 , A61B17/04 , A61B17/128 , A61B17/3205 , A61B17/32
CPC分类号： A61B17/32056 , A61B17/0487 , A61B17/12013 , A61B17/1285 , A61B2017/0488 , A61B2017/12004 , A61B2017/320064
摘要： The present embodiments provide apparatus and methods for treating tissue by applying a force to the tissue. In one embodiment, the apparatus comprises a deployable segment having proximal and distal regions, a main body extending therebetween, and a loop member formed at the distal region of the deployable segment. A cannula having a bore is dimensioned to circumferentially surround at least a portion of the main body at a location proximal to the loop member, and a spring member is disposed between the cannula and the loop member. The proximal end of the spring member is affixed to the cannula, and the distal end of the spring member is movable to apply a compressive force to adjust the size of the opening of the loop member and compress tissue disposed within the opening of the loop member. In an alternative embodiment, the cannula is omitted, and a diameter of the loop member is configured to be reduced and increased any number of times before final deployment of the deployable segment.
摘要翻译： 本实施例提供了通过向组织施加力来治疗组织的装置和方法。 在一个实施例中，该装置包括具有近端区域和远侧区域的可展开区段，在其间延伸的主体以及形成在可部署区段的远侧区域处的环构件。 具有孔的套管的尺寸被设计成在靠近环构件的位置周向地围绕主体的至少一部分，并且弹簧构件设置在套管和环构件之间。 弹簧构件的近端固定到套管上，并且弹簧构件的远端可移动以施加压缩力以调节环构件的开口的尺寸并压缩设置在环构件的开口内的组织 。 在替代实施例中，省略套管，并且环形构件的直径被配置为在可展开段的最终部署之前减少并增加任何次数。
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公开(公告)号：US08777967B2
公开(公告)日：2014-07-15
申请号：US11640106
申请日：2006-12-14
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/0401 , A61B17/0482 , A61B17/0487 , A61B17/0625 , A61B17/12013 , A61B2017/003 , A61B2017/00827 , A61B2017/0409 , A61B2017/0454 , A61B2017/0464 , A61B2017/06176
摘要： The present invention relates to a tissue securement system, device and method for endoscopy or endosonography-guided transluminal interventions through which a ligation is placed and secured into tissue. An objective of this invention is to provide a stable securement platform for the coupling of secondary anchors to the gastrointestinal tract. Specifically, endoscopy is used to insert an anchoring element through the walls of adjacent body cavities. The ends of the anchoring element are coupled together to form a loop. This anchoring element can be used to secure other anchors or devices to the gastrointestinal tract.
摘要翻译： 本发明涉及一种组织固定系统，用于内窥镜检查或内窥镜引导的腔内干预的装置和方法，通过该装置将结扎放置并固定到组织中。 本发明的一个目的是提供一种稳定的固定平台，用于将二级锚定器耦合到胃肠道。 具体地说，内窥镜用于通过相邻体腔的壁插入锚定元件。 锚固元件的端部联接在一起以形成环。 该锚固元件可用于将其它锚固件或装置固定到胃肠道。
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公开(公告)号：US20130310833A1
公开(公告)日：2013-11-21
申请号：US13871978
申请日：2013-04-26
申请人： Peter Brown , Sith Khoune , Keke Lepulu , Ryan Donovan , Kenneth F. Binmoeller
发明人： Peter Brown , Sith Khoune , Keke Lepulu , Ryan Donovan , Kenneth F. Binmoeller
CPC分类号： A61B18/1492 , A61B17/1114 , A61B17/320016 , A61B17/3476 , A61B17/3478 , A61B18/1206 , A61B2017/00278 , A61B2017/3425 , A61B2017/3454 , A61B2017/346 , A61B2018/00345 , A61B2018/00494 , A61B2018/00601 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/144
摘要： Adjacent tissue layers can be accessed using a catheter device with a distal tip having a conductive portion including a first cutting feature and one or more projections extending from the first cutting feature towards an outer diameter of the distal tip. Electrical energy can be supplied to the conductive portion of the device to cut tissue. A stent can be delivered to form a fluid communication between the adjacent tissue layers.
摘要翻译： 相邻的组织层可以使用导管装置进行访问，其中远侧末端具有导电部分，该导电部分包括第一切割特征以及从第一切割特征向远侧末端的外径延伸的一个或多个突起。 电能可以被提供给装置的导电部分以切割组织。 可以输送支架以在相邻组织层之间形成流体连通。
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公开(公告)号：US09888926B2
公开(公告)日：2018-02-13
申请号：US13364265
申请日：2012-02-01
申请人： Hoang Phan , John Lunsford , Kenneth F. Binmoeller
发明人： Hoang Phan , John Lunsford , Kenneth F. Binmoeller
IPC分类号： A61B17/11 , A61B17/00 , A61F2/95 , A61F2/966 , A61B17/02 , A61B17/22 , A61B17/34 , A61B17/29 , A61M27/00
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/0218 , A61B17/11 , A61B17/2909 , A61B2017/00278 , A61B2017/00336 , A61B2017/00862 , A61B2017/1107 , A61B2017/1139 , A61B2017/22038 , A61B2017/3484 , A61B2217/005 , A61F2/95 , A61F2/966 , A61M27/002
摘要： Transluminal access system includes a stent delivery catheter having a handle control mechanism. The catheter comprises a number of components for establishing an initial penetration between adjacent body lumens and subsequently implanting a stent or other luminal anchor therebetween. Manipulation of the stent components is achieved using control mechanisms on the handle while the handle is attached to an endoscope which provides access to a first body lumen.
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公开(公告)号：US20130231689A1
公开(公告)日：2013-09-05
申请号：US13865098
申请日：2013-04-17
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B1/0014 , A61B1/00147 , A61B1/041 , A61B17/0401 , A61B17/0469 , A61B17/1114 , A61B2017/00867 , A61B2017/0408 , A61B2017/0409 , A61B2017/0414 , A61B2017/0454 , A61B2017/0464 , A61B2017/1139 , A61N1/05 , A61N1/36007 , A61N1/3601
摘要： The present invention relates to a device for endoscopy or endosonography-guided transluminal interventions whereby two luminal structures in the body may be drawn toward each other and a fluid conduit formed in between. The device may have a hollow central member to which is coupled a distal retention member and in one embodiment a proximal retention member. The retention members may each be positioned inside one of the luminal structures and expanded from a first condition to an expanded second condition having an increased radius. The length of the central member may be shortened and its diameter expanded to approximate the two retention members and thereby the luminal structures.
摘要翻译： 本发明涉及一种用于内窥镜检查或内窥镜引导的腔内干预的装置，其中身体中的两个腔体结构可以彼此牵拉并且在其间形成流体导管。 该装置可以具有中空的中心构件，其中远端定位构件联接到该中心构件，并且在一个实施例中是近侧定位构件。 保持构件可以各自位于一个管腔结构内，并从第一状态扩展到具有增加的半径的扩张的第二状态。 中心构件的长度可以缩短，并且其直径扩大到近似于两个保持构件，从而使腔体结构近似。
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