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    Conformationally-Stabilized Intraluminal Device for Medical Applications
    1.
    发明申请
    Conformationally-Stabilized Intraluminal Device for Medical Applications 有权
    用于医疗应用的构象稳定的管腔内装置

    公开(公告)号：US20090187206A1

    公开(公告)日：2009-07-23

    申请号：US12174337

    申请日：2008-07-16

    申请人： Kenneth F. Binmoeller ,  James T. McKinley ,  Matthew Yurek ,  Fiona M. Sander

    发明人： Kenneth F. Binmoeller ,  James T. McKinley ,  Matthew Yurek ,  Fiona M. Sander

    IPC分类号： A61M29/00

    CPC分类号： A61F5/0036 ,  A61F5/0013 ,  A61F5/003 ,  A61F5/0076 ,  A61F2002/044 ,  A61F2002/045 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/009

    摘要： The invention relates to devices that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and/or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.

    摘要翻译： 本发明涉及通过其构象（包括长度和曲率的尺寸）稳定在胃肠道内腔内停留部位的装置。 整个装置对应于居住地点的构造; 更具体地，弯曲或成角度的部分对应于居住部位的弯曲或成角度部分，并且不符合直接近端或远端部位。 在一些实施例中，构象稳定的装置可以影响驻留位置形状的变化，这有助于装置的稳定性。 一些实施例旨在限制食欲和/或减少食物摄取，其他实施方案可以针对其他治疗目的。 设备的一些实施例被设计为完全驻留在十二指肠中; 其他的主要存在于十二指肠内，但是向近端延伸到胃窦内，而其它实施例被设计为驻留在胃肠道内的其他地方。

    High vapor pressure attenuation device
    3.
    发明申请
    High vapor pressure attenuation device 有权
    高蒸气压衰减装置

    公开(公告)号：US20060100478A1

    公开(公告)日：2006-05-11

    申请号：US11314601

    申请日：2005-12-20

    申请人： Kevin Connors ,  William Pintauro ,  Sheila Wallin ,  John Kilcoyne ,  Hung Cao ,  Khoi Nguyen ,  Matthew Yurek

    发明人： Kevin Connors ,  William Pintauro ,  Sheila Wallin ,  John Kilcoyne ,  Hung Cao ,  Khoi Nguyen ,  Matthew Yurek

    IPC分类号： A61F2/00

    CPC分类号： A61F2/02 ,  A61F2/042 ,  A61F9/00781 ,  A61F2250/0067

    摘要： Disclosed herein is an attenuation device, comprising a flexible housing and a high vapor pressure media having a vapor pressure approximately equal to the intravesical pressure of the bladder and a permeability of less than 1 ml/day at body temperature through the outer wall of the flexible housing. In one embodiment, the high vapor pressure media comprises perfluorooctylbromide. In another embodiment, the high vapor pressure media comprises perfluorohexane. In yet another embodiment, the high vapor pressure media comprises perfluorodecalin. Also disclosed herein is a method of treating a patient, comprising providing a compressible attenuation device and introducing within the attenuation device at least one high vapor pressure media.

    摘要翻译： 本文公开了一种衰减装置，其包括柔性壳体和高蒸汽压介质，其具有大约等于膀胱的膀胱内压的蒸气压，并且在体温下通过柔性外壁的渗透率小于1ml /天 住房。 在一个实施方案中，高蒸气压介质包含全氟辛基溴。 在另一个实施方案中，高蒸气压介质包括全氟己烷。 在另一个实施方案中，高蒸气压介质包括全氟萘烷。 本文还公开了一种治疗患者的方法，包括提供可压缩衰减装置并在衰减装置内引入至少一个高蒸气压介质。

    METHODS AND DEVICES TO CURB APPETITE AND/OR TO REDUCE FOOD INTAKE
    4.
    发明申请
    METHODS AND DEVICES TO CURB APPETITE AND/OR TO REDUCE FOOD INTAKE 审中-公开
    CURB的方法和设备提示和/或减少食物摄入

    公开(公告)号：US20140114228A1

    公开(公告)日：2014-04-24

    申请号：US14062744

    申请日：2013-10-24

    申请人： Kenneth F. BINMOELLER ,  Matthew YUREK ,  Zhenyong KECK ,  James T. MCKINLEY

    发明人： Kenneth F. BINMOELLER ,  Matthew YUREK ,  Zhenyong KECK ,  James T. MCKINLEY

    IPC分类号： A61F5/00

    CPC分类号： A61F5/0076 ,  A61F2002/044 ,  A61F2002/045 ,  A61F2210/0014 ,  A61N1/36007

    摘要： The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and/or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.

    摘要翻译： 本发明涉及操作有助于抑制食欲和/或减少食物摄取的装置的装置和方法。 在一些实施方案中，本发明的方法和装置包括肠/十二指肠插入物，其包含具有至少一个流动减少元件的细长构件，其可以引起一种或多种饱腹感的生物学信号的刺激。 插入的装置的一些实施例通过驻留在胃中的锚固构件锚定在十二指肠部位，装置的其它实施例通过适当的长度尺寸以及对应的装置的一个或多个成角度部分而被稳定在目标位置 到达目标地点的角部分。 该装置的实施方案由于物理存在以及通过更积极的干预形式（包括释放生物活性物质和电刺激神经元）而发挥作用。

    IMPLANTABLE SELF-INFLATING ATTENUATION DEVICE AND METHOD FOR TREATING OCULAR PRESSURE SPIKES
    6.
    发明申请
    IMPLANTABLE SELF-INFLATING ATTENUATION DEVICE AND METHOD FOR TREATING OCULAR PRESSURE SPIKES 失效
    可植入式自动衰减装置及治疗眼压的方法

    公开(公告)号：US20070225803A1

    公开(公告)日：2007-09-27

    申请号：US11676257

    申请日：2007-02-16

    申请人： Kevin Connors ,  William Pintauro ,  Sheila Wallin ,  John Kilcoyne ,  Hung Cao ,  Khoi Nguyen ,  Matthew Yurek

    发明人： Kevin Connors ,  William Pintauro ,  Sheila Wallin ,  John Kilcoyne ,  Hung Cao ,  Khoi Nguyen ,  Matthew Yurek

    IPC分类号： A61F2/14

    CPC分类号： A61F2/02 ,  A61F2/042 ,  A61F9/00781 ,  A61F2250/0067

    摘要： Disclosed herein is an attenuation device comprising a flexible housing and a medium capable of transformation to inflate the housing from the first configuration to the second configuration. Also disclose herein are methods of treating a patient, comprising: providing a self-inflating expandable attenuation device, containing a medium which is transformable from a first, reduced volume to a second, expanded volume; positioning the attenuation device within the patient at a treatment site; and transforming the medium from the first volume to the second volume. In one embodiment, a self-inflating expandable attenuation device is used to treat glaucoma.

    摘要翻译： 本文公开了一种衰减装置，其包括柔性壳体和能够转换以使壳体从第一构型向第二构型膨胀的介质。 本文还公开了治疗患者的方法，包括：提供自膨胀的可扩张的衰减装置，其包含可从第一减小的体积转变为第二膨胀体积的介质; 将所述衰减装置定位在患者体内的治疗部位; 并将介质从第一卷转换成第二卷。 在一个实施例中，自充气可扩张衰减装置用于治疗青光眼。

    Apparatus and methods for treating sleep apnea
    7.
    发明授权
    Apparatus and methods for treating sleep apnea 有权
    用于治疗睡眠呼吸暂停的装置和方法

    公开(公告)号：US09265649B2

    公开(公告)日：2016-02-23

    申请号：US13324764

    申请日：2011-12-13

    申请人： D. Russell Pflueger ,  Christopher Paul Thompson ,  Steven R. Bacich ,  Richard L. Quick ,  Matthew Yurek

    发明人： D. Russell Pflueger ,  Christopher Paul Thompson ,  Steven R. Bacich ,  Richard L. Quick ,  Matthew Yurek

    IPC分类号： A61F5/56

    CPC分类号： A61F5/566

    摘要： Apparatus and methods are provided for treating sleep apnea, snoring, and the like using an implant within an oropharyngeal region adjacent an anterior longitudinal ligament. The implant may include a relatively narrow central region between first and second relatively wide outer regions. In one embodiment, one of the outer regions is compressible to allow the outer region to be directed through or behind the ligament such that the central region is disposed within or behind the ligament, the outer region being resiliently expandable after passing through or behind the ligament. In another embodiment, the implant may include one or more tines or other features that may be directed into adjacent tissue to secure the implant within the oropharyngeal region.

    摘要翻译： 提供了使用邻近前纵韧带的口咽部区域内的植入物来治疗睡眠呼吸暂停，打鼾等的装置和方法。 植入物可以包括在第一和第二相对宽的外部区域之间的相对窄的中心区域。 在一个实施例中，外部区域之一是可压缩的，以允许外部区域被引导通过韧带的后面或后面，使得中心区域设置在韧带内或后面，外部区域在穿过或穿过韧带之后可弹性地扩张 。 在另一个实施例中，植入物可以包括一个或多个尖齿或可被引导到相邻组织中的其它特征，以将植入物固定在口咽部区域内。

    Methods and devices to curb appetite and/or to reduce food intake
    8.
    发明授权
    Methods and devices to curb appetite and/or to reduce food intake 失效
    抑制食欲和/或减少食物摄入的方法和装置

    公开(公告)号：US08585771B2

    公开(公告)日：2013-11-19

    申请号：US11807107

    申请日：2007-05-25

    申请人： Kenneth F. Binmoeller ,  Matthew Yurek ,  Zhenyong Keck ,  James T. McKinley

    发明人： Kenneth F. Binmoeller ,  Matthew Yurek ,  Zhenyong Keck ,  James T. McKinley

    IPC分类号： A61F2/04

    CPC分类号： A61F5/0076 ,  A61F2002/044 ,  A61F2002/045 ,  A61F2210/0014 ,  A61N1/36007

    摘要： The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and/or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.

    摘要翻译： 本发明涉及操作有助于抑制食欲和/或减少食物摄取的装置的装置和方法。 在一些实施方案中，本发明的方法和装置包括肠/十二指肠插入物，其包含具有至少一个流动减少元件的细长构件，其可以引起一种或多种饱腹感的生物学信号的刺激。 插入的装置的一些实施例通过驻留在胃中的锚固构件锚定在十二指肠部位，装置的其它实施例通过适当的长度尺寸以及对应的装置的一个或多个成角度的部分而被稳定在目标部位 到达目标地点的角部分。 该装置的实施方案由于物理存在以及通过更积极的干预形式（包括释放生物活性物质和电刺激神经元）而发挥作用。