公开(公告)号：US5146832A

公开(公告)日：1992-09-15

申请号：US705189

申请日：1991-05-24

申请人： Kenneth J. Wilson ,  John Morehead

发明人： Kenneth J. Wilson ,  John Morehead

IPC分类号： B21D28/34 ,  B26D7/26

CPC分类号： B21D28/34 ,  B26D7/2614 ,  Y10T403/5761 ,  Y10T403/5793 ,  Y10T403/7039 ,  Y10T83/9423 ,  Y10T83/9476

摘要： A punch has a punch tip with a shank and a punch pad with an orifice for receiving the shank. The punch pad includes a hole positioned closely adjacent the orifice to define a thin wall between the hole and the orifice. The thin wall has a slot which extends through its thickness to define at least one, and preferably two, tabs. An insert, which may be a pin, is provided for insertion into the hole and deforming the tab into supportive, retaining contact with the shank of the punch tip within the orifice. The shank of the punch tip may be provided with a shoulder for abutting the inwardly deformed tab or tabs to restrain withdrawal of the punch tip from the punch pad during operation.

摘要翻译： 冲头具有带柄的冲头和具有用于接收柄的孔的冲压垫。 冲压垫包括紧邻孔口定位的孔，以在孔和孔之间限定一薄壁。 薄壁具有延伸穿过其厚度以限定至少一个，优选两个翼片的槽。 插入件可以是销，用于插入到孔中并使突片变形成支撑的，与孔内的冲头的柄部保持接触。 冲头的柄部可以设置有用于抵靠向内变形的凸片或凸片的肩部，以在操作期间抑制冲头尖端从冲压垫提起。

公开(公告)号：US08697716B2

公开(公告)日：2014-04-15

申请号：US11737517

申请日：2007-04-19

申请人： Carl R. Illig ,  Shelley K. Balltentine ,  Jinsheng Chen ,  Sanath K. Meegalla ,  M. Jonathan Rudolph ,  Mark J. Wall ,  Kenneth J. Wilson ,  Renee L. DesJarlais ,  Carl L. Manthey ,  Christopher J. Molloy

发明人： Carl R. Illig ,  Shelley K. Balltentine ,  Jinsheng Chen ,  Sanath K. Meegalla ,  M. Jonathan Rudolph ,  Mark J. Wall ,  Kenneth J. Wilson ,  Renee L. DesJarlais ,  Carl L. Manthey ,  Christopher J. Molloy

IPC分类号： A61K31/41 ,  A61K31/435

CPC分类号： A61K31/5377 ,  A61K31/4178 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098 ,  C07D307/68 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C12N9/99

摘要： A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to C-KIT using a compound of the present invention: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof. The present invention is further directed to methods for treating conditions such as cancers and other cell proliferative disorders.

摘要翻译： 降低或抑制细胞或受试者中C-KIT的激酶活性的方法，以及使用这些化合物在受试者中预防或治疗细胞增殖性疾病和/或与C-KIT相关的病症的方法， 本发明：或其溶剂合物，水合物，互变异构体或其药学上可接受的盐。 本发明还涉及治疗诸如癌症和其它细胞增殖性疾病的病症的方法。

公开(公告)号：US07645755B2

公开(公告)日：2010-01-12

申请号：US11408096

申请日：2006-04-20

申请人： Carl R. Illig ,  Shelley K. Ballentine ,  Jinsheng Chen ,  Sanath K. Meegalla ,  M. Jonathan Rudolph ,  Mark J. Wall ,  Kenneth J. Wilson ,  Renee L. Desjarlais ,  Carl L. Manthey ,  Christopher Flores ,  Christopher J. Molloy

发明人： Carl R. Illig ,  Shelley K. Ballentine ,  Jinsheng Chen ,  Sanath K. Meegalla ,  M. Jonathan Rudolph ,  Mark J. Wall ,  Kenneth J. Wilson ,  Renee L. Desjarlais ,  Carl L. Manthey ,  Christopher Flores ,  Christopher J. Molloy

IPC分类号： A61K31/5377 ,  A61K31/454 ,  C07D413/14 ,  C07D401/02

CPC分类号： C07D307/71 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14

摘要： The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

公开(公告)号：USH1890H

公开(公告)日：2000-10-03

申请号：US226615

申请日：1998-12-22

申请人： Timothy P. Parr ,  Klaus Schadow ,  Kenneth J. Wilson ,  Robert A. Smith ,  Kenneth Yu

发明人： Timothy P. Parr ,  Klaus Schadow ,  Kenneth J. Wilson ,  Robert A. Smith ,  Kenneth Yu

IPC分类号： F23C15/00 ,  F23G7/06 ,  F23C11/04

CPC分类号： F23C15/00 ,  F23C2205/10 ,  F23G7/065

摘要： This invention involves an improved technique for the modulation of waste an actively controlled compact waste incinerator afterburner. This improved technique utilizes acoustic driving to affect indirect modulation of waste flow velocities. The waste surrogate gases are modulated indirectly by periodic entrainment created by the roll-up of the main air vortex as well as indirect acoustic excitation of secondary air injection. One of the main advantages of this new configuration is the acoustic drivers used to phase inject the waste into the vortex for proper combustion are not in direct contact with the hot waste and therefore can be less expensive and more durable over the long term.

摘要翻译： 本发明涉及用于在主动控制的紧凑型垃圾焚烧炉后燃器中调节废物的改进技术。 这种改进的技术利用声学驱动来影响废物流速的间接调制。 通过主空气涡流的卷起以及二次空气喷射的间接声激发产生的周期夹带间接地调节废弃代用气体。 这种新配置的主要优点之一是用于将废物相位注入涡流以用于适当燃烧的声学驱动器不与热废物直接接触，因此可以在长期内更便宜并且更耐用。

公开(公告)号：USH1008H

公开(公告)日：1992-01-07

申请号：US737763

申请日：1985-05-28

申请人： Klaus C. Schadow ,  Ephraim Gutmark ,  James E. Crump ,  Kenneth J. Wilson

发明人： Klaus C. Schadow ,  Ephraim Gutmark ,  James E. Crump ,  Kenneth J. Wilson

IPC分类号： F02K7/10 ,  F23R3/00 ,  F23R3/12

CPC分类号： F23R3/12 ,  F02K7/10 ,  F23R3/00

摘要： In a combustor in which a flow area for fuel and air increases suddenly at dump so as to generate vortices which mix the fuel and air for combustion downstream of the dump, the improvement in which the flow cross section upstream of the dump is noncircular, as triangular or rectangular, causing flow downstream of the dump to be noncoherent so that mixing by the vortices is aperiodic with the result that heat release on mixing is uniform in time and does not drive oscillations in the combustor.

公开(公告)号：US4248111A

公开(公告)日：1981-02-03

申请号：US057967

申请日：1979-07-16

申请人： Kenneth J. Wilson ,  Ronald G. Rosene

发明人： Kenneth J. Wilson ,  Ronald G. Rosene

IPC分类号： B21D28/34 ,  B21D45/00 ,  B26D7/06 ,  B26F1/14

CPC分类号： B21D28/34 ,  B21D45/006 ,  Y10T83/2159 ,  Y10T83/9476

摘要： A punch guide assembly having a removable stripper plate. The assembly includes clip tabs having stripper plate holding tabs formed on ends thereof for disposition through a hole provided in the punch guide and for reception within an appropriate recess in the stripper plate for retaining the stripper plate. The assembly also includes a grooved track disposed about the punch guide and a tool for insertion therein to urge the clip tabs outwardly of the punch guide, to facilitate insertion and removal of the stripper plate.

摘要翻译： 具有可拆卸剥离板的冲头引导组件。 组件包括夹板，其具有形成在其端部上的剥离板保持突片，用于通过设置在冲头引导件中的孔布置，并且用于接纳在剥离板中的适当的凹部中，用于保持剥离板。 组件还包括围绕冲头引导件设置的开槽轨道和用于插入其中的工具，以将夹子突出部推向冲头引导件的外部，以便于剥离板的插入和移除。

公开(公告)号：US07296396B1

公开(公告)日：2007-11-20

申请号：US11014376

申请日：2004-12-14

申请人： Kenneth J. Wilson ,  Warrent K. Jaul ,  Shannon L. Fitzpatrick ,  Robert G. Burman

发明人： Kenneth J. Wilson ,  Warrent K. Jaul ,  Shannon L. Fitzpatrick ,  Robert G. Burman

IPC分类号： C06B43/00

CPC分类号： B64G7/00 ,  B64G1/401 ,  B64G1/58 ,  F02K7/10 ,  F02K7/14 ,  F05D2220/10 ,  F05D2250/51 ,  F05D2250/52 ,  F23R5/00

摘要： A supersonic combustion apparatus and method for using the same including a fixed geometric nozzle having a converging area, throat, and a diverging area, at least one fuel injection means and at least one flame stabilization means located in the divergent area, and an exit plane adjacent and downstream to the diverging area, where an initial first injection/flame stabilization means is located in the diverging area and the exit plane Mach is varied by heat addition in the diverging area by at least one more fuel injection means.

摘要翻译： 一种超音速燃烧装置及其使用方法，包括具有会聚区域，喉部和发散区域的固定几何喷嘴，至少一个燃料喷射装置和位于发散区域中的至少一个火焰稳定装置，以及出射平面 相邻和下游到发散区域，其中初始的第一喷射/火焰稳定装置位于发散区域中，并且出射平面马赫通过至少一个以上燃料喷射装置在发散区域中的热量添加而改变。

公开(公告)号：US06291514B1

公开(公告)日：2001-09-18

申请号：US09372748

申请日：1999-08-11

申请人： Carl R. Illig ,  Nalin L. Subasinghe ,  James B. Hoffman ,  Kenneth J. Wilson ,  M. Jonathan Rudolph ,  Juan José Marugán

发明人： Carl R. Illig ,  Nalin L. Subasinghe ,  James B. Hoffman ,  Kenneth J. Wilson ,  M. Jonathan Rudolph ,  Juan José Marugán

IPC分类号： A61K3138

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： The present invention is directed to compounds of Formula I: wherein X is O, S or NR7 and R1-R7, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.

摘要翻译： 本发明涉及式I化合物：其中X是O，S或NR 7，R 1 -R 7，Y和Z在说明书中列出，以及其水合物，溶剂合物或其药学上可接受的盐。 还描述了制备式I化合物的方法。本发明的新化合物是蛋白酶的有效抑制剂，特别是胰蛋白酶样丝氨酸蛋白酶，例如胰凝乳蛋白酶，胰蛋白酶，纤溶酶和尿激酶。 某些化合物表现出对尿激酶的直接选择性抑制，或者是用于形成具有这种活性的化合物的中间体。

公开(公告)号：US5149908A

公开(公告)日：1992-09-22

申请号：US751362

申请日：1991-08-19

申请人： Klaus C. Schadow ,  Ephraim Gutmark ,  Kenneth J. Wilson ,  Robert A. Smith

发明人： Klaus C. Schadow ,  Ephraim Gutmark ,  Kenneth J. Wilson ,  Robert A. Smith

IPC分类号： F41A1/04

CPC分类号： F41A1/04

摘要： A regenerative liquid propellant gun and pertains includes a modified contional fixed bolt extending into a conventional combustion chamber of the regenerative liquid propellant gun. The modified fixed bolt of this invention provides for improved operation of the otherwise conventional regenerative liquid propellant gun and has modified end portion embodiments and internal propellant injection passages, all for the purpose of creating turbulent propellant flow.

摘要翻译： 再生式液体推进剂枪包括延伸到再生液体推进剂枪的常规燃烧室中的改进的常规固定螺栓。 本发明的改进的固定螺栓提供了改进的常规再生液体推进剂枪的操作，并且具有改进的端部实施例和内部推进剂注射通道，所有这些都是为了产生湍流推进剂流。

公开(公告)号：US08087229B2

公开(公告)日：2012-01-03

申请号：US11970231

申请日：2008-01-07

申请人： Kenneth J. Wilson ,  Warren K. Jaul ,  Robert G. Burman ,  Shannon L. Fitzpatrick

发明人： Kenneth J. Wilson ,  Warren K. Jaul ,  Robert G. Burman ,  Shannon L. Fitzpatrick

IPC分类号： F02K1/00 ,  F02K1/28

CPC分类号： F42C15/32

摘要： A supersonic combustion apparatus including a fixed geometric nozzle having a converging area, throat, and a diverging area, at least one movable combination of a fuel injector and an oxygen injector where the combined fuel injector and the oxygen injector is located within the divergent area of the fixed geometric nozzle, and an exit plane adjacent and downstream to the diverging area. The exit plane Mach speed is varied by heat addition in the diverging area by introduction of a combustible fuel through the fuel injector and oxygen through the oxygen injector and then axially aligning and positioning the combination of the fuel injector and the oxygen injector along the length of the diverging area to obtain a stabilized flame at the exit plane.

摘要翻译： 一种超音速燃烧设备，包括具有会聚区域，喉部和发散区域的固定几何喷嘴，燃料喷射器和氧气喷射器的至少一个可移动组合，其中组合燃料喷射器和氧气喷射器位于 固定的几何喷嘴，以及与发散区域相邻和下游的出口平面。 通过通过燃料喷射器引入可燃燃料并通过氧气喷射器引入氧气，然后沿燃料喷射器和氧气喷射器的长度轴向对准和定位燃料喷射器和氧气喷射器的组合，使出口平面马赫速度通过在发散区域中的热量加法而变化 发散区域在出口平面处获得稳定的火焰。