公开(公告)号：US08087229B2

公开(公告)日：2012-01-03

申请号：US11970231

申请日：2008-01-07

申请人： Kenneth J. Wilson ,  Warren K. Jaul ,  Robert G. Burman ,  Shannon L. Fitzpatrick

发明人： Kenneth J. Wilson ,  Warren K. Jaul ,  Robert G. Burman ,  Shannon L. Fitzpatrick

IPC分类号： F02K1/00 ,  F02K1/28

CPC分类号： F42C15/32

摘要： A supersonic combustion apparatus including a fixed geometric nozzle having a converging area, throat, and a diverging area, at least one movable combination of a fuel injector and an oxygen injector where the combined fuel injector and the oxygen injector is located within the divergent area of the fixed geometric nozzle, and an exit plane adjacent and downstream to the diverging area. The exit plane Mach speed is varied by heat addition in the diverging area by introduction of a combustible fuel through the fuel injector and oxygen through the oxygen injector and then axially aligning and positioning the combination of the fuel injector and the oxygen injector along the length of the diverging area to obtain a stabilized flame at the exit plane.

摘要翻译： 一种超音速燃烧设备，包括具有会聚区域，喉部和发散区域的固定几何喷嘴，燃料喷射器和氧气喷射器的至少一个可移动组合，其中组合燃料喷射器和氧气喷射器位于 固定的几何喷嘴，以及与发散区域相邻和下游的出口平面。 通过通过燃料喷射器引入可燃燃料并通过氧气喷射器引入氧气，然后沿燃料喷射器和氧气喷射器的长度轴向对准和定位燃料喷射器和氧气喷射器的组合，使出口平面马赫速度通过在发散区域中的热量加法而变化 发散区域在出口平面处获得稳定的火焰。

公开(公告)号：US07662837B2

公开(公告)日：2010-02-16

申请号：US11254276

申请日：2005-10-20

申请人： Carl R. Illig ,  Shelley K. Ballentine ,  Jinsheng Chen ,  Sanath K. Meegalla ,  M. Jonathan Rudolph ,  Mark J. Wall ,  Kenneth J. Wilson ,  Renee L. Desjarlais ,  Carl L. Manthey ,  Christopher Flores ,  Christopher J. Molloy

发明人： Carl R. Illig ,  Shelley K. Ballentine ,  Jinsheng Chen ,  Sanath K. Meegalla ,  M. Jonathan Rudolph ,  Mark J. Wall ,  Kenneth J. Wilson ,  Renee L. Desjarlais ,  Carl L. Manthey ,  Christopher Flores ,  Christopher J. Molloy

IPC分类号： A61K31/454 ,  C07D401/02

CPC分类号： C07D307/71 ,  C07D401/12 ,  C07D401/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14

摘要： The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

摘要翻译： 本发明涉及式I化合物：其中A，X，R 2和W在本说明书中阐述，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体及其药学上可接受的盐 。 治疗自身免疫性疾病的方法 和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，结肠癌，胃癌，毛细胞白血病和非小细胞肺癌的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 还提供了骨质疏松症，佩吉特氏病和其它骨吸收介导包括关节炎，假体失败，溶骨性骨肉瘤，骨髓瘤以及与式I化合物对骨的肿瘤转移的其它疾病。

公开(公告)号：US06948306B1

公开(公告)日：2005-09-27

申请号：US10337667

申请日：2002-12-24

申请人： Kenneth J. Wilson ,  Timothy P. Parr ,  Ken Yu ,  Jaul Warren

发明人： Kenneth J. Wilson ,  Timothy P. Parr ,  Ken Yu ,  Jaul Warren

IPC分类号： B63H11/00 ,  B64G1/40 ,  B64G1/58 ,  B64G7/00 ,  B64G99/00 ,  F02K7/10 ,  F02K7/14 ,  F02K9/00 ,  F23R5/00 ,  B64G9/00 ,  F03H9/00 ,  F23R9/00

CPC分类号： B64G7/00 ,  B64G1/401 ,  B64G1/58 ,  F02K7/10 ,  F02K7/14 ,  F05D2220/10 ,  F05D2250/51 ,  F05D2250/52 ,  F23R5/00

摘要： A supersonic combustion apparatus and method of using the same including a side wall cavity having an enhanced mixing system with ground-based oxygen injection for hypersonic material and engine testing.

摘要翻译： 一种超音速燃烧装置及其使用方法，其包括具有增强的混合系统的侧壁空腔，其具有用于超音速材料和发动机测试的基于地面的氧气喷射。

公开(公告)号：US06492403B1

公开(公告)日：2002-12-10

申请号：US09500783

申请日：2000-02-09

申请人： Carl R. Illig ,  Nalin L. Subasinghe ,  James B. Hoffman ,  Kenneth J. Wilson ,  M. Jonathan Rudolph ,  Roger F. Bone ,  Scott L. Klein ,  Troy L. Randle

发明人： Carl R. Illig ,  Nalin L. Subasinghe ,  James B. Hoffman ,  Kenneth J. Wilson ,  M. Jonathan Rudolph ,  Roger F. Bone ,  Scott L. Klein ,  Troy L. Randle

IPC分类号： A61K31427

CPC分类号： C07D409/04 ,  A61K31/427 ,  C07D333/38 ,  C07D409/12 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4, X, Y and Z are defined in the specification.

摘要翻译： 公开了一种治疗由补体级联的经典途径介导的急性或慢性障碍的症状的方法，其包括向需要这种治疗的哺乳动物施用治疗有效量的式I化合物或溶剂合物，水合物或药学上 其可接受的盐; 其中R1，R2，R3，R4，X，Y和Z在说明书中定义。

公开(公告)号：USH1931H

公开(公告)日：2001-01-02

申请号：US08982134

申请日：1997-12-01

申请人： Timothy P. Parr ,  Kenneth J. Wilson ,  Kenneth Yu ,  Klaus Schadow ,  Robert A. Smith

发明人： Timothy P. Parr ,  Kenneth J. Wilson ,  Kenneth Yu ,  Klaus Schadow ,  Robert A. Smith

IPC分类号： F23G500

CPC分类号： F23C15/00 ,  F23C2205/10 ,  F23G7/065

摘要： This invention involves an improved technique for the modulation of waste in an actively controlled compact waste incinerator afterburner. This improved technique utilizes acoustic driving to affect indirect modulation of waste flow velocities. The waste surrogate gases are modulated indirectly by periodic entrainment created by the roll-up of the main air vortex as well as indirect acoustic excitation of secondary air injection. One of the main advantages of this new configuration is the acoustic drivers used to phase inject the waste into the vortex for proper combustion are not in direct contact with the hot waste and therefore can be less expensive and more durable over the long term.

摘要翻译： 本发明涉及用于在主动控制的紧凑型垃圾焚烧炉后燃器中调节废物的改进技术。 这种改进的技术利用声学驱动来影响废物流速的间接调制。 通过主空气涡流的卷起以及二次空气喷射的间接声激发产生的周期夹带间接地调节废弃代用气体。 这种新配置的主要优点之一是用于将废物相位注入涡流以用于适当燃烧的声学驱动器不与热废物直接接触，因此可以在长期内更便宜并且更耐用。

公开(公告)号：US6003360A

公开(公告)日：1999-12-21

申请号：US886648

申请日：1997-07-01

申请人： David M. Runk ,  Kenneth J. Wilson ,  Jason A. Doolittle ,  Wayne F. Peloquin ,  Richard L. Timp

发明人： David M. Runk ,  Kenneth J. Wilson ,  Jason A. Doolittle ,  Wayne F. Peloquin ,  Richard L. Timp

IPC分类号： B21D37/14 ,  B21D5/02 ,  B21D37/04

CPC分类号： B21D5/0236 ,  B21D5/0209

摘要： A press brake tool holder having a horizontally elongated body having a support plate, and a horizontally elongated clamp having upper and lower portions and pivotally attached to the body between the upper and lower portions so as to capture between it and the support plate the upwardly extending shank of a brake press tool. A handle-operated cam shaft is carried by the body and is linked to the upper portion of the clamp by cam follower elements which provide a rigid linkage. Clamps may be thus mounted to both sides of the body, and each can be independently operated when the other is removed. The clamp is mounted to the body by means of mounting pins having articulating heads that are slidingly received in slots in the body, the slots having enlarged entryways enabling the clamp to be removed from or attached to the body by sliding the clamp with respect to the body to align the articulating heads with the slot entryways.

摘要翻译： 具有具有支撑板的水平细长主体的压制工具保持器和具有上部和下部的水平细长夹具，并且在上部和下部之间枢转地附接到主体，以便在其与支撑板之间捕获向上延伸的 制动压机工具的柄。 手柄操作的凸轮轴由主体承载并通过提供刚性连杆的凸轮从动元件连接到夹具的上部。 夹具可以这样安装到主体的两侧，并且每个夹具可以在另一个被移除时独立地操作。 夹具通过具有铰接头的安装销安装到主体上，该铰接头滑动地容纳在主体中的狭槽中，该狭槽具有扩大的入口通道，使夹具能够相对于 主体将铰接头与槽入口对准。

公开(公告)号：US4446767A

公开(公告)日：1984-05-08

申请号：US325650

申请日：1981-11-30

申请人： Kenneth J. Wilson

发明人： Kenneth J. Wilson

IPC分类号： B21D45/00 ,  B26D7/18 ,  B21D45/08

CPC分类号： B21D45/006 ,  Y10T83/215 ,  Y10T83/2159 ,  Y10T83/9457

摘要： A removeable stripper plate assembly. The assembly includes a punch guide sleeve with a stripper plate support means to aid in supporting a stripper plate within and at the end of the punch guide sleeve. A split locking ring having adjacent ends moveable toward and away from each other is received in a groove in the punch guide sleeve, and extends inwardly of the punch guide sleeve to lock the stripper plate in place. Locking means are provided to maintain the spacing between ends of the split locking ring to thereby maintain it in the groove.

摘要翻译： 可拆卸的剥离板组件。 组件包括具有剥离板支撑装置的冲头引导套筒，以帮助在冲头引导套筒的内部和底部支撑剥离板。 具有相互移动并彼此远离的相邻端部的分离锁定环被容纳在冲头引导套筒的凹槽中，并且在冲头引导套筒的内部延伸以将剥离板锁定在适当的位置。 提供锁定装置以保持分离锁定环的端部之间的间隔，从而将其保持在凹槽中。

公开(公告)号：US4092888A

公开(公告)日：1978-06-06

申请号：US812128

申请日：1977-07-01

申请人： Kenneth J. Wilson

发明人： Kenneth J. Wilson

IPC分类号： B21D28/34 ,  B21D45/00 ,  B26F1/14

CPC分类号： B21D45/006 ,  B21D28/34 ,  Y10T83/2159 ,  Y10T83/2166 ,  Y10T83/8785

摘要： A punching device for use in a fixed frame adapted to support punch means in alignment with a ram. An assembly of a punch, a guide and stripper plate and a stripping spring is removable as a unit. The assembly of this invention is characterized by means by which the assembly is retained together when removed from the frame of the punching machine. The assembly includes a quick release guide, a clip ring spring support retainer and a replaceable stripper plate.

摘要翻译： 一种用于固定框架的冲压装置，其适于支撑与冲头对准的冲压装置。 冲头，引导件和剥离板和剥离弹簧的组件可作为一个单元移动。 本发明的组件的特征在于，当从冲孔机的框架移除时，组件保持在一起。 组件包括快速释放引导件，夹环弹簧支撑保持器和可替换的剥离板。

公开(公告)号：US06640549B1

公开(公告)日：2003-11-04

申请号：US10421186

申请日：2003-04-24

申请人： Kenneth J. Wilson ,  Kenneth H. Yu ,  Timothy Parr ,  Klaus C. Schadow

发明人： Kenneth J. Wilson ,  Kenneth H. Yu ,  Timothy Parr ,  Klaus C. Schadow

IPC分类号： F02C500

CPC分类号： F02C5/00 ,  F02K7/02 ,  F05D2260/96 ,  F23M20/005 ,  F23R2900/00013 ,  F23R2900/03281

摘要： This invention relates to air breathing engines, such as ramjets, scramjets and internal combustion, and more particularly to an active combustion control device for a combustor. In more particularity, the present invention relates to a method and apparatus that applies active combustion control technology to advanced propulsion devices and closed-loop fuel injection at sub-harmonic frequencies of the instability frequency of the combustor. The problem of limited actuator frequency response is addressed by injecting fuel pulses at sub-harmonic frequencies of the instability. The fuel may be liquid, solid or gas. To achieve this desired result, a closed loop controller is designed to determine sub-harmonic frequencies using a divider to divide the instability frequency of a combustor, yielding a fraction of the harmonic frequency. Also, this invention also combines open loop injection control with closed loop injection control to obtain enhanced engine performance, which includes extension of the stable combustion zone.

公开(公告)号：US06562840B1

公开(公告)日：2003-05-13

申请号：US10082127

申请日：2002-02-26

申请人： Carl R. Illig ,  Nalin L. Subasinghe ,  James B. Hoffman ,  Kenneth J. Wilson ,  M. Jonathan Rudolph ,  Juan José Marugán

发明人： Carl R. Illig ,  Nalin L. Subasinghe ,  James B. Hoffman ,  Kenneth J. Wilson ,  M. Jonathan Rudolph ,  Juan José Marugán

IPC分类号： A61K3147

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： The present invention is directed to compounds of Formula I: wherein X is O, S or NR7 and R1—R7, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.

摘要翻译： 本发明涉及式I化合物：其中X是O，S或NR 7，R 1 -R 7，Y和Z在说明书中列出，以及其水合物，溶剂合物或其药学上可接受的盐。 还描述了制备式I化合物的方法。本发明的新化合物是蛋白酶的有效抑制剂，特别是胰蛋白酶样丝氨酸蛋白酶，例如胰凝乳蛋白酶，胰蛋白酶，纤溶酶和尿激酶。 某些化合物表现出对尿激酶的直接选择性抑制，或者是用于形成具有这种活性的化合物的中间体。