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公开(公告)号：US20120214972A1
公开(公告)日：2012-08-23
申请号：US12908517
申请日：2010-10-20
IPC分类号： C07K16/28
CPC分类号： C07K14/70521 , C07K14/70532 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
摘要翻译： 本发明提供了一种称为BTLA的新型淋巴细胞抑制受体，其在T细胞和B细胞上表达，并鉴定B7家族成员B7x与BTLA相互作用以减弱淋巴细胞活性。 还提供了用于调节BTLA介导的负信号并干扰BTLA和B7x的相互作用用于治疗，诊断和研究目的的方法和组合物。
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公开(公告)号：US20120232259A1
公开(公告)日：2012-09-13
申请号：US13438628
申请日：2012-04-03
IPC分类号： C12N15/117
CPC分类号： C07K14/70521 , C07K14/70532 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
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公开(公告)号：US20080269464A1
公开(公告)日：2008-10-30
申请号：US11875537
申请日：2007-10-19
IPC分类号： C07K14/705 , C07K16/00
CPC分类号： C07K14/70521 , C07K14/70532 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
摘要翻译： 本发明提供了一种称为BTLA的新型淋巴细胞抑制受体，其在T细胞和B细胞上表达，并鉴定B7家族成员B7x与BTLA相互作用以减弱淋巴细胞活性。 还提供了用于调节BTLA介导的负信号并干扰BTLA和B7x的相互作用用于治疗，诊断和研究目的的方法和组合物。
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公开(公告)号：US20120322986A1
公开(公告)日：2012-12-20
申请号：US13474101
申请日：2012-05-17
申请人： Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
发明人： Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
IPC分类号： C07K16/28
CPC分类号： C07K14/70521 , A61K2039/505 , C07K14/70532 , C07K16/2818 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
摘要翻译： 本发明提供一种称为BTLA的新型淋巴细胞抑制受体，其在T细胞和B细胞上表达，并且将HVEM识别为与BTLA相互作用。 还提供了用于调节BTLA介导的信号传导和干扰BTLA和HVEM的相互作用用于治疗，诊断和研究目的的方法和组合物。
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公开(公告)号：US08546541B2
公开(公告)日：2013-10-01
申请号：US12977562
申请日：2010-12-23
申请人： Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
发明人： Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
IPC分类号： C07K16/00
CPC分类号： C07K14/70521 , A61K2039/505 , C07K14/70532 , C07K16/2818 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
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公开(公告)号：US20110230647A1
公开(公告)日：2011-09-22
申请号：US12977562
申请日：2010-12-23
申请人： Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
发明人： Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
IPC分类号： C07K16/18
CPC分类号： C07K14/70521 , A61K2039/505 , C07K14/70532 , C07K16/2818 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
摘要翻译： 本发明提供一种称为BTLA的新型淋巴细胞抑制受体，其在T细胞和B细胞上表达，并且将HVEM识别为与BTLA相互作用。 还提供了用于调节BTLA介导的信号传导和干扰BTLA和HVEM的相互作用用于治疗，诊断和研究目的的方法和组合物。
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公开(公告)号：US07304149B2
公开(公告)日：2007-12-04
申请号：US10600997
申请日：2003-06-20
CPC分类号： C07K14/70521 , C07K14/70532 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
摘要翻译： 本发明提供了一种称为BTLA的新型淋巴细胞抑制受体，其在T细胞和B细胞上表达，并鉴定B7家族成员B7x与BTLA相互作用以减弱淋巴细胞活性。 还提供了用于调节BTLA介导的负信号并干扰BTLA和B7x的相互作用用于治疗，诊断和研究目的的方法和组合物。
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公开(公告)号：US09045562B2
公开(公告)日：2015-06-02
申请号：US13341611
申请日：2011-12-30
申请人： Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
发明人： Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
IPC分类号： C07K16/28 , C07K14/705 , A61K39/00
CPC分类号： C07K14/70521 , A61K2039/505 , C07K14/70532 , C07K16/2818 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
摘要翻译： 本发明提供一种称为BTLA的新型淋巴细胞抑制受体，其在T细胞和B细胞上表达，并且将HVEM识别为与BTLA相互作用。 还提供了用于调节BTLA介导的信号传导和干扰BTLA和HVEM的相互作用用于治疗，诊断和研究目的的方法和组合物。
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公开(公告)号：US20120207759A1
公开(公告)日：2012-08-16
申请号：US13341611
申请日：2011-12-30
申请人： Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
发明人： Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
IPC分类号： A61K39/395 , C12N5/02 , A61P37/02 , C07K16/28 , A61P35/00
CPC分类号： C07K14/70521 , A61K2039/505 , C07K14/70532 , C07K16/2818 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
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公开(公告)号：US20110229434A1
公开(公告)日：2011-09-22
申请号：US13052404
申请日：2011-03-21
申请人： RENE DE WAAL MALEFYT , Liu Yong-Jun , Marehalli L. Nagalakshmi , Vassili Soumelis , Norihiko Watanabe , Wei Yuan
发明人： RENE DE WAAL MALEFYT , Liu Yong-Jun , Marehalli L. Nagalakshmi , Vassili Soumelis , Norihiko Watanabe , Wei Yuan
IPC分类号： A61K39/395 , A61K38/20 , A61P37/00 , A61P29/00 , A61P17/06 , A61P19/02 , A61P11/06 , A61P11/00 , C12N5/0783 , C12N5/078
CPC分类号： C07K14/7155 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K14/5418 , C07K16/244
摘要： Provided are methods of modulating dendritic cell activity using agonists or antagonists of a mammalian cytokine. Also provided are methods of treating immune disorders.
摘要翻译： 提供使用哺乳动物细胞因子的激动剂或拮抗剂调节树突状细胞活性的方法。 还提供了治疗免疫疾病的方法。
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