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    Method and apparatus for producing oriented plastic strap
    3.
    发明申请
    Method and apparatus for producing oriented plastic strap 有权
    用于生产定向塑料带的方法和设备

    公开(公告)号：US20050218552A1

    公开(公告)日：2005-10-06

    申请号：US10818300

    申请日：2004-04-05

    申请人： Donald Van Erden ,  James Kniola ,  Kenneth Rinehart ,  Otto Weber

    发明人： Donald Van Erden ,  James Kniola ,  Kenneth Rinehart ,  Otto Weber

    IPC分类号： B29C43/24 ,  B29C53/16 ,  B29C55/06 ,  B29C55/18 ,  B29D7/00

    CPC分类号： B29C55/18 ,  B29C55/06

    摘要： A method of producing a plastic sheet-strap includes the steps of providing first and second work rollers such that the work rollers rotate in opposite directions and at different lineal surface velocities. The work rollers are spaced apart with respect to each other so as to define a work roller nip therebetween. A pinch roller is provided that is operably associated with the first work roller. The pinch roller and the first roller defining a deaerating nip therebetween. A solid sheet of material having a thickness is fed into the deaerating nip. The material is pinched against the first work roller and moves with rotation of the first work roller to the work roller nip between the first and second work rollers. The material is simultaneously milled and stretched substantially at the nip during a single pass of the solid sheet material through the nip as the rollers rotate in opposite directions and at different lineal surface velocities to form a milled and stretched oriented sheet. The second roller has a concave profile to work the edges of the sheet more than a central region of the sheet. A chill roller is disposed downstream of the second work roller to cool the milled and stretched oriented sheet.

    摘要翻译： 制造塑料片带的方法包括以下步骤：提供第一和第二加工辊，使得加工辊沿相反方向和不同的线速表面速度旋转。 工作辊相对于彼此间隔开，以便在它们之间限定工作辊辊隙。 提供了与第一工作辊可操作地相关联的夹送辊。 夹送辊和第一辊在其间限定脱气辊隙。 具有厚度的固体材料片材被供给到脱气辊隙中。 材料被夹在第一工作辊上并随着第一工作辊的旋转移动到第一和第二工作辊之间的工作辊辊隙。 当辊在相反方向和不同的线速度下旋转时，在固体片材通过辊隙单次通过期间，材料被同时研磨和拉伸，以形成研磨且拉伸的取向片材。 第二辊具有凹形轮廓以使片材的边缘比片材的中心区域更加均匀。 冷却辊设置在第二工作辊的下游，以冷却被研磨和拉伸的取向片材。

    Bear derived isolate and method
    6.
    发明申请
    Bear derived isolate and method 审中-公开

    公开(公告)号：US20060204589A1

    公开(公告)日：2006-09-14

    申请号：US11407319

    申请日：2006-04-19

    申请人： Ralph Nelson ,  Patricia Miers ,  Kenneth Rinehart

    发明人： Ralph Nelson ,  Patricia Miers ,  Kenneth Rinehart

    IPC分类号： A61K35/16

    CPC分类号： A61K35/22 ,  A61K35/16

    摘要： A bear derived isolate found in denning black bears or black bears from which food has been withheld for at least two weeks when injected into another mammal produces reduced heart rate, reduced respiratory rate, reduced temperature, and a wakeful tranquility not unlike the phenomena of the denning black bear. The isolate is taken from either the serum or urine of such denning bear. The method of the invention involves the steps of fractionating the serum or urine of a denning black bear to produce fractions of varying potency.

    Ecteinascidins
    7.
    发明申请
    Ecteinascidins 审中-公开

    公开(公告)号：US20060030571A1

    公开(公告)日：2006-02-09

    申请号：US11132466

    申请日：2005-05-18

    申请人： Kenneth Rinehart ,  Ryuichi Sakai

    发明人： Kenneth Rinehart ,  Ryuichi Sakai

    IPC分类号： A61K31/519 ,  C07D491/14

    CPC分类号： C07D515/22

    摘要： The present invention is directed to several newly discovered ecteinascidin (Et) species, designated herein as Et 731, Et 745B, Et 815, Et 808, Et 596, Et 597, Et 583, Et 594 and a synthetic derivative of Et 594, N-Acetyl Et 597. The physical properties of these compounds, their preparation and bioactivities are also reported.

    摘要翻译： 本发明涉及几种新发现的被称为Et 731，Et 745B，Et 815，Et 808，Et 596，Et 597，Et 583，Et 594和Et 594的合成衍生物，N， - 乙酰基Et 597.还报道了这些化合物的物理性质，它们的制备和生物活性。

    Ecteinascidins 736 and 722
    9.
    发明授权
    Ecteinascidins 736 and 722 失效
    ECTEINASCIDINS 736 AND 722

    公开(公告)号：US5149804A

    公开(公告)日：1992-09-22

    申请号：US620427

    申请日：1990-11-30

    申请人： Kenneth Rinehart ,  Ryuichi Sakai

    发明人： Kenneth Rinehart ,  Ryuichi Sakai

    IPC分类号： A61K31/435 ,  A61P35/00 ,  C07D515/22

    CPC分类号： C07D515/22

    摘要： Ecteinascidins 722 and 736 (Et's 722 and 736) have been isolated from the Caribbean tunicate Ecteinascidia turbinata and their structures have been assigned as tetrahydro-.beta.-carboline-substituted bis(tetrahydro- isoquinolines) related to the previously reported Et's 729 and 743. Et's 722 and 736 protect mice in vivo at very low concentrations against P388 lymphoma, B16 melanoma, and Lewis lung carcinoma.

    摘要翻译： Ecteinascidins 722和736（Et的722和736）已经从加勒比海带的Ecteinascidia turbinata中分离出来，其结构被分配为与先前报道的Et的729和743相关的四氢-β-咔啉取代的双（四氢 - 异喹啉）。Et 722和736保护小鼠在非常低的浓度对P388淋巴瘤，B16黑素瘤和Lewis肺癌。