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公开(公告)号：US08029817B2
公开(公告)日：2011-10-04
申请号：US12245554
申请日：2008-10-03
申请人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
IPC分类号： A61F2/00 , A61K9/14 , A61K33/42 , A61K33/00 , C01F11/00 , C01B25/32 , C01B33/24 , A01N59/26 , A01N59/00
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si-OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译： 本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。 硅取代的氧磷灰石化合物具有式Ca 5（PO 4）3-x（SiO 4）x O（1-x）/ 2，其中0
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公开(公告)号：US07115743B2
公开(公告)日：2006-10-03
申请号：US11009237
申请日：2004-12-10
申请人： Kenneth L. Rinehart , Jose J. Morales , Joel Reid , Isabel Reymundo , Pablo Floriano , Lola Garcia Gravalos
发明人： Kenneth L. Rinehart , Jose J. Morales , Joel Reid , Isabel Reymundo , Pablo Floriano , Lola Garcia Gravalos
IPC分类号： C07D221/18
CPC分类号： C07D515/22 , C07D217/10 , C07D317/64
摘要： The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:
摘要翻译： 已经完成了人细胞色素CYP3A4对几种Et 743代谢产物的纯化和结构解析。 这些化合物在本文中简称为“ETM”，后面是表示近似分子量的数值。 目前已经鉴定了三种化合物，即ETM 305，ETM 775和ETM 204.这些ecteinidinidin代谢物的结构如下：
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公开(公告)号：US20050261326A1
公开(公告)日：2005-11-24
申请号：US11009237
申请日：2004-12-10
申请人： Kenneth Rinehart , Jose Morales , Joel Reid , Isabel Reymindo , Pablo Floriano , Lola Gravalos
发明人： Kenneth Rinehart , Jose Morales , Joel Reid , Isabel Reymindo , Pablo Floriano , Lola Gravalos
IPC分类号： A61K31/357 , A61K31/36 , A61K31/39 , A61K31/47 , A61K31/472 , A61K31/4747 , A61K31/4995 , A61K35/02 , A61P35/00 , C07D217/10 , C07D217/24 , C07D317/44 , C07D317/64 , C07D317/66 , C07D327/02 , C07D411/14 , C07D491/14 , C07D497/22 , C07D515/22
CPC分类号： C07D515/22 , C07D217/10 , C07D317/64
摘要： The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:
摘要翻译： 已经完成了人细胞色素CYP3A4对几种Et 743代谢产物的纯化和结构解析。 这些化合物在本文中简称为“ETM”，后面是表示近似分子量的数值。 目前已经鉴定了三种化合物，即ETM 305，ETM 775和ETM 204.这些ecteinidinidin代谢物的结构如下：
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公开(公告)号：US07498043B2
公开(公告)日：2009-03-03
申请号：US11088094
申请日：2005-03-24
申请人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译： 本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。 硅取代的氧磷灰石化合物具有式Ca 5（PO 4）3-x（SiO 4）x O（1-x）/ 2，其中0
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公开(公告)号：US20090030089A1
公开(公告)日：2009-01-29
申请号：US12245554
申请日：2008-10-03
申请人： Michael Sayer , Joel Reid , Timothy J.N. Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy J.N. Smith , Jason Hendry
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译： 本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。 硅取代的氧磷灰石化合物具有式Ca 5（PO 4）3-x（SiO 4）x O（1-x）/ 2，其中0
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公开(公告)号：US20050244449A1
公开(公告)日：2005-11-03
申请号：US11088094
申请日：2005-03-24
申请人： Michael Sayer , Joel Reid , Timothy Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy Smith , Jason Hendry
IPC分类号： A61F13/00 , A61K33/42 , A61L24/00 , A61L27/12 , A61L27/32 , A61L27/42 , A61L27/46 , A61L27/54 , C01B15/16 , C01B25/32 , C01B33/20
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译： 本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。 硅取代的氧磷灰石化合物具有式Ca 3（PO 4）3-x（SiO 4） （1-x）/ 2 <0，其中0
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7.发明授权Metabolites of ecteinascidin 743 formed by human cytochrome CYP3A4 失效人细胞色素CYP3A4形成的ecteinascidin 743的代谢物公开(公告)号：US06867334B2
公开(公告)日：2005-03-15
申请号：US09971852
申请日：2001-10-03
申请人： Kenneth L. Rinehart , Jose J. Morales , Joel Reid , Isabel Reymundo , Pablo Floriano , Lola Garcia Gravalos
发明人： Kenneth L. Rinehart , Jose J. Morales , Joel Reid , Isabel Reymundo , Pablo Floriano , Lola Garcia Gravalos
IPC分类号： A61K31/357 , A61K31/36 , A61K31/39 , A61K31/47 , A61K31/472 , A61K31/4747 , A61K31/4995 , A61K35/02 , A61P35/00 , C07D217/10 , C07D217/24 , C07D317/44 , C07D317/64 , C07D317/66 , C07D327/02 , C07D411/14 , C07D491/14 , C07D497/22 , C07D515/22 , C07C205/00
CPC分类号： C07D515/22 , C07D217/10 , C07D317/64
摘要： The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:
摘要翻译： 已经完成了人细胞色素CYP3A4对几种Et 743代谢产物的纯化和结构解析。 这些化合物在本文中简称为“ETM”，后面是表示近似分子量的数值。 目前已经鉴定了三种化合物，即ETM 305，ETM 775和ETM 204.这些ecteinidinidin代谢物的结构如下：
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公开(公告)号：US06316214B1
公开(公告)日：2001-11-13
申请号：US09309947
申请日：1999-05-11
申请人： Kenneth L. Rinehart , Jose J. Morales , Joel Reid , Isabel Reymundo , Pablo Floriano , Lola Garcia Gravalos
发明人： Kenneth L. Rinehart , Jose J. Morales , Joel Reid , Isabel Reymundo , Pablo Floriano , Lola Garcia Gravalos
IPC分类号： C12Q126
CPC分类号： C07D515/22 , C07D217/10 , C07D317/64
摘要： The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value, which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:
摘要翻译： 已经完成了人细胞色素CYP3A4对几种Et 743代谢产物的纯化和结构解析。 这些化合物在本文中简称为“ETM”，随后是表示近似分子量的数值。 目前已经鉴定了三种化合物，即ETM 305，ETM 775和ETM 204.这些ecteinidinidin代谢物的结构如下：
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