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    Anti-infective medical device
    1.
    发明授权
    Anti-infective medical device 有权
    抗感染医疗器械

    公开(公告)号：US08691258B2

    公开(公告)日：2014-04-08

    申请号：US11008445

    申请日：2004-12-09

    申请人： Kenneth T. Heruth ,  Christopher M. Hobot ,  William J. Hooper ,  Mark S. Lent ,  Ruchika Singhal ,  Robert M. Skime ,  Randall V. Sparer ,  Maura G. Donovan ,  William J. Bertrand

    发明人： Kenneth T. Heruth ,  Christopher M. Hobot ,  William J. Hooper ,  Mark S. Lent ,  Ruchika Singhal ,  Robert M. Skime ,  Randall V. Sparer ,  Maura G. Donovan ,  William J. Bertrand

    IPC分类号： A61F13/00 ,  A01N25/00

    CPC分类号： A61N1/05 ,  A61N1/0568 ,  A61N1/375

    摘要： Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.

    摘要翻译： 描述具有抗感染性的植入式医疗装置（IMDS）。 抗感染剂设置在医疗装置的表面的至少一部分上，其上或附近。 抗感染剂设置在车辆中或车辆上，其可以是涂层或覆盖物的形式。 载体可以是可生物降解的，使得随着时间的推移，抗感染剂从植入装置所在的组织位置移除，降低了抗感染剂抗微生物的可能性。 还描述了其上设置有抗感染剂和抗活性剂的IMD，其上或其上。 干扰抗感染剂的活性的抗活性剂可以在不再需要抗感染剂的活性的时候从IMD的表面释放，并且可能降低抗微生物抗性的可能性 抗感染剂会发展。

    Pacemaker
    2.
    发明授权
    Pacemaker 失效
    起搏器

    公开(公告)号：US5456698A

    公开(公告)日：1995-10-10

    申请号：US158832

    申请日：1993-11-23

    申请人： James K. Byland ,  Michael D. DeFranco ,  William J. Hooper ,  James M. Sikorski ,  David L. Thompson

    发明人： James K. Byland ,  Michael D. DeFranco ,  William J. Hooper ,  James M. Sikorski ,  David L. Thompson

    IPC分类号： A61N1/375

    CPC分类号： A61N1/375 ,  A61N1/37229 ,  A61N1/3758

    摘要： An enclosure for use in pacemaker as well as other implantable medical devices has a substantially planar lid which is welded to a circumferential flange formed on a deep drawn shield. The shield and lid form a "container" which is encased in a compliant shroud which isolates the welded flange from direct body contact and which enhances the biocompatibility of the entire device. A resilient and compliant shroud material accepts connector module components, integrates seals, provides storage for lead wrap, and provides a simple low cost and reliable method of attaching stimulating leads or other structures required by the medical device.

    摘要翻译： 用于起搏器和其它可植入医疗装置的外壳具有基本上平坦的盖子，其被焊接到形成在深拉屏蔽上的圆周凸缘。 屏蔽罩和盖子形成一个“容器”，其被包裹在顺应的护罩中，其将焊接的凸缘与直接的身体接触隔离，并且增强了整个装置的生物相容性。 弹性和柔顺的护罩材料接受连接器模块组件，集成密封件，提供铅封的存储，并提供简单的低成本和可靠的方法来附接刺激引线或医疗设备所需的其他结构。

    Method and apparatus for accessing a nonvolatile memory
    3.
    发明授权
    Method and apparatus for accessing a nonvolatile memory 失效
    用于访问非易失性存储器的方法和装置

    公开(公告)号：US5080096A

    公开(公告)日：1992-01-14

    申请号：US549568

    申请日：1990-07-06

    申请人： William J. Hooper ,  David L. Thompson

    发明人： William J. Hooper ,  David L. Thompson

    IPC分类号： A61N1/365 ,  A61N1/37 ,  A61N1/372

    CPC分类号： A61N1/37252 ,  A61N1/36542 ,  A61N1/37

    摘要： A method and apparatus for accessing a nonvolatile electrically erasable programmable read only memory (EEPROM) following hermetic closure of a device containing the EEPROM. The EEPROM is accessed by a direct connection to a feedthrough pin extending through the hermetic enclosure. Following hermetic sealing, the memory is still accessible for programming.In the implantable medical device field, the invention may be utilized to program in the device serial number or similar data which may be telemetered out of the device on command of an external programmer/transciever in order to identify the device. In a specific application, a rate responsive pacemaker, an activity sensor mounted within the hermetically sealed enclosure is electrically connected to the EEPROM and other operating circuitry. At final test, the output of the activity sensor may be checked against specific levels of mechanical activity input applied to the exterior of the enclosure by observing the pacing rates developed from the sensor signal values, calculating a gain factor and storing the gain factor(s) in the EEPROM for adjusting the activity sensor derived pacing rate through its normal range of response. This trimming of the response of the activity sensor minimizes the number of completed medical devices that fail to meet specification tolerances and allows those tolerances to be narrowed to assure relatively consistent variations in pacing rate as a function of applied mechanical force. Once the factor(s) is stored and its accuracy is confirmed by retesting the pacing rate, the dedicated feedthrough pin is removed or rendered inaccessible.

    摘要翻译： 一种用于在密封关闭包含EEPROM的装置之后访问非易失性电可擦除可编程只读存储器（EEPROM）的方法和装置。 通过直接连接到延伸穿过密封外壳的馈通销来访问EEPROM。 密封密封后，仍然可以进行编程。 在可植入医疗器械领域中，本发明可用于编程设备序列号或类似数据，该数据可以根据外部编程器/转码器的命令从设备中遥测出来，以识别该设备。 在具体应用中，速率响应起搏器，安装在密封外壳内的活动传感器电连接到EEPROM和其它操作电路。 在最终测试中，活动传感器的输出可以通过观察从传感器信号值产生的起搏速率，计算增益因子并存储增益因子（s）来检查施加到外壳外部的机械活动输入的特定水平 ）在EEPROM中，用于通过其正常的响应范围来调整活动传感器得到的起搏速率。 对活动传感器的响应的这种修剪使得不能满足规格公差的完成的医疗装置的数量最小化，并且允许这些公差被缩小以确保作为施加的机械力的函数的起搏速率的相对一致的变化。 一旦保存了因子，并通过重新测试起搏速率来确认其准确性，则专用馈通引脚被移除或不可访问。