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公开(公告)号：US08691258B2
公开(公告)日：2014-04-08
申请号：US11008445
申请日：2004-12-09
申请人： Kenneth T. Heruth , Christopher M. Hobot , William J. Hooper , Mark S. Lent , Ruchika Singhal , Robert M. Skime , Randall V. Sparer , Maura G. Donovan , William J. Bertrand
发明人： Kenneth T. Heruth , Christopher M. Hobot , William J. Hooper , Mark S. Lent , Ruchika Singhal , Robert M. Skime , Randall V. Sparer , Maura G. Donovan , William J. Bertrand
CPC分类号： A61N1/05 , A61N1/0568 , A61N1/375
摘要： Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.
摘要翻译： 描述具有抗感染性的植入式医疗装置（IMDS）。 抗感染剂设置在医疗装置的表面的至少一部分上，其上或附近。 抗感染剂设置在车辆中或车辆上，其可以是涂层或覆盖物的形式。 载体可以是可生物降解的，使得随着时间的推移，抗感染剂从植入装置所在的组织位置移除，降低了抗感染剂抗微生物的可能性。 还描述了其上设置有抗感染剂和抗活性剂的IMD，其上或其上。 干扰抗感染剂的活性的抗活性剂可以在不再需要抗感染剂的活性的时候从IMD的表面释放，并且可能降低抗微生物抗性的可能性 抗感染剂会发展。
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公开(公告)号：US20080069856A1
公开(公告)日：2008-03-20
申请号：US11523841
申请日：2006-09-20
申请人： SuPing Lyu , Christopher M. Hobot , Sean M. Haddock , Brian Loy , Randall V. Sparer , K. Matthew Kinnane , Jeffrey M. Gross
发明人： SuPing Lyu , Christopher M. Hobot , Sean M. Haddock , Brian Loy , Randall V. Sparer , K. Matthew Kinnane , Jeffrey M. Gross
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/3683 , A61L27/58 , C08L67/04
摘要： A process for making an implantable material comprising a composite of a biocompatible polymer and a bioactive agent. The composite combines desirable mechanical properties of polymers and the bioactivity of tissue or one or more component of tissue. More particularly, but not exclusively, the invention relates to methods for the manufacture of implantable materials, devices and components via a powder molding process.
摘要翻译： 一种用于制造可植入材料的方法，其包括生物相容性聚合物和生物活性剂的复合物。 该复合物结合聚合物的所需机械性能和组织的生物活性或组织的一种或多种组分。 更具体地但不排他地，本发明涉及通过粉末成型工艺制造可植入材料，装置和部件的方法。
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公开(公告)号：US07101956B2
公开(公告)日：2006-09-05
申请号：US10292993
申请日：2002-11-13
申请人： Michael Eric Benz , Edward DiDomenico , Christopher M. Hobot , Randall V. Sparer , Kenneth B. Wagener , John E. Schwendeman
发明人： Michael Eric Benz , Edward DiDomenico , Christopher M. Hobot , Randall V. Sparer , Kenneth B. Wagener , John E. Schwendeman
IPC分类号： C08G18/63
CPC分类号： C08G18/6204 , A61L27/18 , C08F236/20 , C08L101/02 , C08L75/00
摘要： Compounds that include diorgano groups having quaternary carbons and optionally urethane groups, urea groups, or combinations thereof (i.e., polyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.
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4.发明授权Implantable medical device having flat electrolytic capacitor with connector block and sealed feedthroughs 失效具有扁平电解电容器的可插入式医疗设备，具有连接器块和密封馈通公开(公告)号：US06212063B1
公开(公告)日：2001-04-03
申请号：US09104104
申请日：1998-06-24
申请人： William L. Johnson , Anthony R. Rorvick , Mark D. Breyen , Paul A. Pignato , Norma K. Bullock , Joseph F. Lessar , Andrew J. Ries , Randall V. Sparer , Christopher M. Hobot , Edward Di Domenico , Steven G. Rockow
发明人： William L. Johnson , Anthony R. Rorvick , Mark D. Breyen , Paul A. Pignato , Norma K. Bullock , Joseph F. Lessar , Andrew J. Ries , Randall V. Sparer , Christopher M. Hobot , Edward Di Domenico , Steven G. Rockow
IPC分类号： H01G908
CPC分类号： A61N1/375 , A61N1/3758 , A61N1/3956
摘要： An implantable medical device such as a defibrillator is described. The device includes an hermetically sealed housing containing a flat electrolytic capacitor and an energy source such as a battery. The battery is connected to the capacitor and provides charge thereto. The capacitor stores the charge at a relatively high voltage. The charge stored in the capacitor is discharged through a defibrillation lead to a site on or in the heart when fibrillation of the heart is detected by the implantable medical device. Methods of making and using the implantable medical device, the capacitor, and their various components are disclosed.
摘要翻译： 描述了诸如除颤器的可植入医疗装置。 该装置包括一个包含平坦的电解电容器和诸如电池的能量源的气密密封的外壳。 电池连接到电容器并提供电荷。 电容器将电荷存储在较高的电压。 存储在电容器中的电荷通过除颤导线排出到心脏上或心脏中的部位，通过可植入医疗装置检测心脏的颤动。 公开了制造和使用可植入医疗装置，电容器及其各种部件的方法。
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5.发明授权公开(公告)号：US06984700B2
公开(公告)日：2006-01-10
申请号：US10246807
申请日：2002-09-17
申请人： Michael Eric Benz , Christopher M. Hobot , David L. Miller , David A. Pearson , Mark A. Tapsak , Edward DiDomenico , Randall V. Sparer
发明人： Michael Eric Benz , Christopher M. Hobot , David L. Miller , David A. Pearson , Mark A. Tapsak , Edward DiDomenico , Randall V. Sparer
IPC分类号： C08L83/05
摘要： Compounds that include silicon-containing groups, and optionally urethane groups, urea groups, or combinations thereof (i.e., polyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.
摘要翻译： 包括含硅基团和任选的氨基甲酸酯基团，脲基团或其组合（即聚氨酯，聚脲或聚氨酯 - 脲）的化合物以及用于制备这些化合物的材料和方法。
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公开(公告)号：US08637064B2
公开(公告)日：2014-01-28
申请号：US11523841
申请日：2006-09-20
申请人： SuPing Lyu , Christopher M. Hobot , Sean M. Haddock , Brian A. Loy , Randall V. Sparer , K. Matthew Kinnane , Jeffrey M. Gross
发明人： SuPing Lyu , Christopher M. Hobot , Sean M. Haddock , Brian A. Loy , Randall V. Sparer , K. Matthew Kinnane , Jeffrey M. Gross
IPC分类号： A61F2/00
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/3683 , A61L27/58 , C08L67/04
摘要： A process for making an implantable material comprising a composite of a biocompatible polymer and a bioactive agent. The composite combines desirable mechanical properties of polymers and the bioactivity of tissue or one or more component of tissue. More particularly, but not exclusively, the invention relates to methods for the manufacture of implantable materials, devices and components via a powder molding process.
摘要翻译： 一种用于制造可植入材料的方法，其包括生物相容性聚合物和生物活性剂的复合物。 该复合物结合聚合物的所需机械性能和组织的生物活性或组织的一种或多种组分。 更具体地但不排他地，本发明涉及通过粉末成型工艺制造可植入材料，装置和部件的方法。
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公开(公告)号：US20110269720A1
公开(公告)日：2011-11-03
申请号：US12768913
申请日：2010-04-28
CPC分类号： A61K31/495 , A61K31/65 , A61K2300/00
摘要： Methods and kits for treating infection associated with implantation of a medical device use of minocycline and rifampin microparticles. The microparticles, in a suitable medium, can be injected in a patient in proximity to the device. The drugs may be configured to be released from the polymer matrix in a controlled manner by manipulation of the properties of the polymer forming the microparticle. By injecting the drugs in the form of microparticles, the drugs can be distributed in a manner so that the entire pocket is protected without affecting device function. The microparticles can be produced aseptically without affecting the manufacturing of the device.
摘要翻译： 用于治疗与植入医疗器械相关的感染的方法和试剂盒使用米诺环素和利福平微粒。 在合适的介质中的微粒可以被注射到设备附近的患者体内。 药物可以被配置为通过操纵形成微粒的聚合物的性质以受控的方式从聚合物基质释放。 通过以微粒的形式注射药物，药物可以以使得整个口袋被保护而不影响装置功能的方式分布。 微粒可以无菌地生产，而不影响器件的制造。
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8.发明授权公开(公告)号：US07365134B2
公开(公告)日：2008-04-29
申请号：US11133627
申请日：2005-05-20
申请人： Michael Eric Benz , Christopher M. Hobot , David L. Miller , David A. Pearson , Mark A. Tapsak , Edward DiDomenico , Randall V. Sparer
发明人： Michael Eric Benz , Christopher M. Hobot , David L. Miller , David A. Pearson , Mark A. Tapsak , Edward DiDomenico , Randall V. Sparer
IPC分类号： C08L83/05
摘要： Compounds that include silicon-containing groups, and optionally urethane groups, urea groups, or combinations thereof (i.e., polyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.
摘要翻译： 包括含硅基团和任选的氨基甲酸酯基团，脲基团或其组合（即聚氨酯，聚脲或聚氨酯 - 脲）的化合物以及用于制备这些化合物的材料和方法。
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公开(公告)号：US20070249754A1
公开(公告)日：2007-10-25
申请号：US11789131
申请日：2007-04-24
申请人： SuPing Lyu , Thomas P. Grailer , James Louis Schley , Christopher M. Hobot , Christopher A. Deegan , Randall V. Sparer
发明人： SuPing Lyu , Thomas P. Grailer , James Louis Schley , Christopher M. Hobot , Christopher A. Deegan , Randall V. Sparer
CPC分类号： C08K5/19 , C08K9/04 , C08L75/04 , C08L75/08 , C08L2666/62
摘要： Methods of modifying polyurethanes using surface treated clay are disclosed herein. Such methods can be useful for controlling the surface concentration of one or more additives in the polyurethane, which can be useful for fabricating medical devices therefrom.
摘要翻译： 本文公开了使用表面处理的粘土改性聚氨酯的方法。 这种方法可用于控制聚氨酯中的一种或多种添加剂的表面浓度，其可用于从其制备医疗装置。
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公开(公告)号：US08940315B2
公开(公告)日：2015-01-27
申请号：US12426031
申请日：2009-04-17
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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