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公开(公告)号：US20150363558A1
公开(公告)日：2015-12-17
申请号：US13603284
申请日：2012-09-04
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , G16B20/00 , G16B40/00
摘要： The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an endometriosis related symptom.
摘要翻译： 本发明涉及与子宫内膜异位症和子宫内膜异位症发生风险相关的新型遗传标记，以及用于确定人受试者是否具有子宫内膜异位症或处于发展子宫内膜异位症风险的方法和材料，以及使用这种风险信息来选择性地施用治疗 至少部分预防或补偿子宫内膜异位症相关症状。
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公开(公告)号：US20150368714A1
公开(公告)日：2015-12-24
申请号：US13789082
申请日：2013-03-07
申请人： Kenneth Ward , Rakesh N. Chettier , Hans Albertsen
发明人： Kenneth Ward , Rakesh N. Chettier , Hans Albertsen
IPC分类号： C12Q1/68
CPC分类号： A61K31/566 , C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an endometriosis related symptom.
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公开(公告)号：US09434991B2
公开(公告)日：2016-09-06
申请号：US13789082
申请日：2013-03-07
申请人： Kenneth Ward , Rakesh N. Chettier , Hans Albertsen
发明人： Kenneth Ward , Rakesh N. Chettier , Hans Albertsen
IPC分类号： C12Q1/68
CPC分类号： A61K31/566 , C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an endometriosis related symptom.
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公开(公告)号：US08932993B1
公开(公告)日：2015-01-13
申请号：US13788913
申请日：2013-03-07
申请人： Kenneth Ward , Rakesh N. Chettier , Hans Albertsen
发明人： Kenneth Ward , Rakesh N. Chettier , Hans Albertsen
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an endometriosis related symptom.
摘要翻译： 本发明涉及与子宫内膜异位症和子宫内膜异位症发生风险相关的新型遗传标记，以及用于确定人受试者是否具有子宫内膜异位症或处于发展子宫内膜异位症风险的方法和材料，以及使用这种风险信息来选择性地施用治疗 至少部分预防或补偿子宫内膜异位症相关症状。
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公开(公告)号：US20100272713A1
公开(公告)日：2010-10-28
申请号：US12765643
申请日：2010-04-22
申请人： Kenneth Ward , Hans Albertsen
发明人： Kenneth Ward , Hans Albertsen
IPC分类号： A61K39/395 , A61K38/16 , A61K31/7088 , A61P15/00 , C12Q1/68
CPC分类号： G01N33/56905 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2333/445
摘要： The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an endometriosis related symptom.
摘要翻译： 本发明涉及与子宫内膜异位症和子宫内膜异位症发生风险相关的新型遗传标记，以及用于确定人受试者是否具有子宫内膜异位症或处于发展子宫内膜异位症风险的方法和材料，以及使用这种风险信息来选择性地施用治疗 至少部分预防或补偿子宫内膜异位症相关症状。
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公开(公告)号：US20080305967A1
公开(公告)日：2008-12-11
申请号：US12056754
申请日：2008-03-27
申请人： Kenneth Ward , Hans Albertsen
发明人： Kenneth Ward , Hans Albertsen
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis.
摘要翻译： 本发明涉及与子宫内膜异位症和子宫内膜异位症发展相关的新型遗传标记，以及用于确定人受试者是否具有子宫内膜异位症或处于发展子宫内膜异位症风险的方法和材料。
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公开(公告)号：US06413727B1
公开(公告)日：2002-07-02
申请号：US08449731
申请日：1995-05-25
申请人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
发明人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
IPC分类号： G01N33574
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译： 公开了一种称为APC的人类基因。 提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。 家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。 这些结果表明APC是肿瘤抑制因子。
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公开(公告)号：USRE40948E1
公开(公告)日：2009-10-27
申请号：US09983543
申请日：2001-10-24
申请人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakumura , Andrew Thliveris , Raymond White
发明人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuke Nakumura , Andrew Thliveris , Raymond White
IPC分类号： C07K16/30 , A61K39/395
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译： 公开了一种称为APC的人类基因。 提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。 家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。 这些结果表明APC是肿瘤抑制因子。
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公开(公告)号：US6114124A
公开(公告)日：2000-09-05
申请号：US450582
申请日：1995-05-25
申请人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
发明人： Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Kenneth Kinzler , Alexander Fred Markham , Yusuke Nakamura , Andrew Thliveris , Bert Vogelstein , Raymond L. White
IPC分类号： C07K14/47 , C07K14/82 , C07K16/32 , C12N5/12 , C12N15/12 , C12Q1/68 , G01N33/53 , G01N33/48 , G01N33/574
CPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10S530/828
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译： 公开了一种称为APC的人类基因。 提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。 家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。 这些结果表明APC是肿瘤抑制因子。
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公开(公告)号：USRE38916E1
公开(公告)日：2005-12-06
申请号：US09442489
申请日：1999-11-18
申请人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuka Nakamura , Andrew Thilveris , Raymond L. White
发明人： Bert Vogelstein , Kenneth W. Kinzler , Hans Albertsen , Rakesh Anand , Mary Carlson , Joanna Groden , Philip John Hedge , Geoff Joslyn , Alexander Fred Markham , Yusuka Nakamura , Andrew Thilveris , Raymond L. White
CPC分类号： C07K14/47
摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
摘要翻译： 公开了一种称为APC的人类基因。 提供了用于评估人类组织和身体样品中APC基因突变的方法和试剂盒。 家族性腺瘤性息肉病患者以及散发性结肠直肠癌患者发现APC突变。 APC在大多数正常组织中表达。 这些结果表明APC是肿瘤抑制因子。
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