公开(公告)号：US08080780B2

公开(公告)日：2011-12-20

申请号：US12649159

申请日：2009-12-29

申请人： Kent C. Burr ,  Daniel Gagnon

发明人： Kent C. Burr ,  Daniel Gagnon

IPC分类号： G01D18/00

CPC分类号： G01T1/208 ,  G01T1/1647

摘要： An apparatus and associated method for gamma ray detection that improves the timing resolution is provided. A crystal of interaction in a scintillation crystal array emits scintillation light in response to interaction with a gamma ray. The scintillation light is detected by one or more photomultiplier tubes. Each photomultiplier tube that detects the scintillation light detects the light at a different time. The apparatus determines the location of the gamma ray interaction and uses the location of the interaction to generate correction times for each waveform generated by the photomultiplier tubes. The waveforms are corrected with the correction timings and combined to extract a time of arrival estimate for the gamma ray. Noise thresholding is also used to select waveforms having low noise for combination to extract the time of arrival estimate.

摘要翻译： 提供了一种提高定时分辨率的用于伽马射线检测的装置和相关方法。 闪烁晶体阵列中的相互作用晶体响应于与γ射线的相互作用发射闪烁光。 闪烁光由一个或多个光电倍增管检测。 检测闪烁光的每个光电倍增管在不同的时间检测光。 该装置确定伽马射线相互作用的位置，并使用相互作用的位置来产生由光电倍增管产生的每个波形的校正时间。 波形用校正定时校正并组合以提取伽马射线的到达时间估计值。 噪声阈值也用于选择具有低噪声的波形用于组合以提取到达时间估计。

公开(公告)号：US20120305782A1

公开(公告)日：2012-12-06

申请号：US13153021

申请日：2011-06-03

申请人： Kent C. BURR ,  Daniel Gagnon ,  Zhengyan Wang

发明人： Kent C. BURR ,  Daniel Gagnon ,  Zhengyan Wang

IPC分类号： G01T1/20

CPC分类号： G01T1/2985 ,  G01T1/1644 ,  H01L31/02325

摘要： A positron emission tomography (PET) detector module includes an array of scintillation crystal elements and a plurality of photosensors arranged to at least partially cover the array of scintillation crystal elements. The photosensors are configured to receive light emitted from the array of scintillation crystal elements. The module includes a transparent adhesive arranged between the array of scintillation crystal elements and the plurality of photosensors. The transparent adhesive extends directly from a surface of at least one of the scintillation crystal elements to a surface of at least one of the photosensors and is configured to distribute the light emitted from one of the scintillation crystal elements to more than one of the photosensors. A method of manufacturing the module includes various steps utilizing a fixture. A PET scanner uses multiple modules arranged circumferentially around an area to be scanned.

摘要翻译： 正电子发射断层摄影（PET）检测器模块包括闪烁晶体元件阵列和布置成至少部分地覆盖闪烁晶体元件阵列的多个光电传感器。 光传感器被配置为接收从闪烁晶体元件阵列发射的光。 该模块包括布置在闪烁晶体元件阵列与多个光电传感器之间的透明粘合剂。 透明粘合剂从至少一个闪烁晶体元件的表面直接延伸到至少一个光电传感器的表面，并且被配置为将从一个闪烁晶体元件发射的光分布到多于一个光电传感器中。 制造该模块的方法包括利用夹具的各种步骤。 PET扫描器使用围绕要扫描的区域周向布置的多个模块。

公开(公告)号：US08633444B2

公开(公告)日：2014-01-21

申请号：US13153021

申请日：2011-06-03

申请人： Kent C. Burr ,  Daniel Gagnon ,  Zhengyan Wang

发明人： Kent C. Burr ,  Daniel Gagnon ,  Zhengyan Wang

IPC分类号： G01T1/164

CPC分类号： G01T1/2985 ,  G01T1/1644 ,  H01L31/02325

摘要： A positron emission tomography (PET) detector module includes an array of scintillation crystal elements and a plurality of photosensors arranged to at least partially cover the array of scintillation crystal elements. The photosensors are configured to receive light emitted from the array of scintillation crystal elements. The module includes a transparent adhesive arranged between the array of scintillation crystal elements and the plurality of photosensors. The transparent adhesive extends directly from a surface of at least one of the scintillation crystal elements to a surface of at least one of the photosensors and is configured to distribute the light emitted from one of the scintillation crystal elements to more than one of the photosensors. A method of manufacturing the module includes various steps utilizing a fixture. A PET scanner uses multiple modules arranged circumferentially around an area to be scanned.

公开(公告)号：US09207333B2

公开(公告)日：2015-12-08

申请号：US13091761

申请日：2011-04-21

申请人： Daniel Gagnon

发明人： Daniel Gagnon

IPC分类号： G01T1/164 ,  G01T1/29 ,  A61B6/03

CPC分类号： G01T1/2985 ,  A61B6/037

摘要： A positron emission tomography (PET) scanner, including a first detector portion arranged circumferentially around a patient pallet, the first detector portion having a predetermined axial extent and transaxially subtending more than 180 degrees, but less than 360 degrees with respect to a central axis of the scanner defined by the first detector portion; and a second detector portion arranged separately from and opposing the first detector section, the second detector portion having a radius of curvature smaller than a radius of curvature of the first detector portion, wherein the second detector portion transaxially subtends less than 180 degrees with respect to the central axis of the scanner.

摘要翻译： 正电子发射断层摄影（PET）扫描仪，包括围绕患者托盘周向布置的第一检测器部分，第一检测器部分具有预定的轴向范围，并且相对于中心轴线的轴向轴向对角超过180度但小于360度 所述扫描仪由所述第一检测器部分限定; 以及第二检测器部分，其与第一检测器部分分开设置并相对于第二检测器部分，第二检测器部分具有小于第一检测器部分的曲率半径的曲率半径，其中第二检测器部分相对于 扫描仪的中心轴。

公开(公告)号：US09194960B2

公开(公告)日：2015-11-24

申请号：US13545614

申请日：2012-07-10

申请人： Daniel Gagnon ,  Kent Burr

发明人： Daniel Gagnon ,  Kent Burr

IPC分类号： G01T1/20 ,  G02B6/06 ,  G02B6/08 ,  G01T1/164

CPC分类号： G01T1/1644 ,  G01T1/2006 ,  G01T1/2018 ,  G02B6/06 ,  G02B6/08

摘要： A positron emission tomography scanner system that includes detector modules arranged adjacent to one another to form a cylindrical detector ring. Each of the detector modules includes an array of scintillation crystal elements, a plurality of photosensors arranged to cover the array of crystal elements and configured to receive light emitted from the array of crystal elements, and a fiber optics plate arranged between the array of scintillation crystal elements and the plurality of photosensors, the fiber optics plate including a plurality of fibers configured to guide the light emitted from the scintillation crystal to the plurality of photosensors.

摘要翻译： 正电子发射断层摄影扫描仪系统，其包括彼此相邻布置以形成圆柱形检测器环的检测器模块。 每个检测器模块包括闪烁晶体元件阵列，多个光电传感器布置成覆盖晶体元件阵列并被配置为接收从晶体元件阵列发射的光，以及布置在闪烁晶体阵列之间的光纤板 元件和多个光电传感器，所述光纤板包括被配置为将从闪烁晶体发射的光引导到多个光电传感器的多个光纤。

公开(公告)号：US08809792B2

公开(公告)日：2014-08-19

申请号：US13630787

申请日：2012-09-28

申请人： Wenli Wang ,  Daniel Gagnon ,  Xiaofeng Niu

发明人： Wenli Wang ,  Daniel Gagnon ,  Xiaofeng Niu

IPC分类号： G06F19/00 ,  G01T1/164 ,  G01T1/29 ,  A61B6/03 ,  G06T11/00

CPC分类号： G01T1/2985 ,  A61B6/03 ,  A61B6/032 ,  A61B6/037 ,  A61B6/4258 ,  A61B6/4417 ,  A61B6/5205 ,  G06F19/00 ,  G06T11/005

摘要： A method and apparatus for determining a coincidence window for imaging a region of interest of an object using a Positron Emission Tomography (PET) scanner. The method includes determining a diameter of a transverse field of view (FOV) for imaging the region of interest of the object; and calculating the coincidence window based on the determined diameter, a ring diameter of the PET scanner, an axial length of the PET scanner, and a time-of-flight resolution of the PET scanner.

摘要翻译： 一种用于使用正电子发射断层摄影（PET）扫描仪确定用于对物体感兴趣区域成像的符合窗口的方法和装置。 该方法包括确定用于对物体的感兴趣区域成像的横视场（FOV）的直径; 以及基于确定的直径，PET扫描仪的环直径，PET扫描器的轴向长度和PET扫描仪的飞行时间分辨率来计算重合窗口。

公开(公告)号：US08660636B2

公开(公告)日：2014-02-25

申请号：US13145115

申请日：2009-12-23

申请人： Daniel Gagnon ,  Piotr J. Maniawski

发明人： Daniel Gagnon ,  Piotr J. Maniawski

IPC分类号： A61B5/00

CPC分类号： G06T11/006 ,  A61B6/037

摘要： A method for reconstructing list mode data comprises: reconstructing all list mode data of a list mode data set (30, 160) to generate a first reconstructed image (32, 62); selecting a sub-set of the list mode data set; and reconstructing the sub-set of the list mode data set to generate an enhanced reconstructed image (84, 86). An image generation system comprises: a reconstruction module (24) configured to perform a standard reconstruction of a list mode data set to generate a standard reconstructed image (32, 62); and a re-reconstruction module (24, 70, 80, 82, 150, 152, 154) configured to perform a reconstruction other than the standard reconstruction of at least a portion of the list mode data set to generate an enhanced reconstructed image (84, 86).

摘要翻译： 重建列表模式数据的方法包括：重建列表模式数据集（30,160）的所有列表模式数据，以生成第一重建图像（32,62）; 选择列表模式数据集的子集; 以及重建列表模式数据集的子集以生成增强的重建图像（84,86）。 一种图像生成系统包括：重建模块（24），被配置为执行列表模式数据集的标准重建以生成标准重建图像（32,62）; 以及重建重建模块（24,70,80,82,150,152,154），其被配置为执行不同于所述列表模式数据集的至少一部分的标准重建的生成增强重建图像（84 ，86）。

公开(公告)号：US08516636B2

公开(公告)日：2013-08-27

申请号：US12195655

申请日：2008-08-21

申请人： Daniel Gagnon ,  Michael A. Morich ,  Douglas M. Blakeley

发明人： Daniel Gagnon ,  Michael A. Morich ,  Douglas M. Blakeley

IPC分类号： A61B6/04

CPC分类号： A61B5/0555 ,  A61B5/0035 ,  A61B6/032 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/4429

摘要： A hybrid imaging system and a patient bed for same are disclosed. The hybrid imaging system includes a magnetic resonance scanner and a second modality imaging system spaced apart from the magnetic resonance scanner by a gap. In some embodiments, the gap is less than seven meters. The patient bed is disposed at least partially in the gap between the magnetic resonance scanner and the second modality imaging system, and includes a linearly translatable patient support pallet aligned to be selectively moved into an examination region of the magnetic resonance scanner for magnetic resonance imaging and into an examination region of the second modality imaging system for second modality imaging. In some embodiments, a linear translation range of the linearly translatable pallet is less than five times a length of the patient support pallet along the direction of linear translation.

摘要翻译： 公开了一种混合成像系统和用于其的患者床。 混合成像系统包括磁共振扫描器和通过间隙与磁共振扫描器隔开的第二模态成像系统。 在一些实施例中，间隙小于7米。 患者床至少部分地设置在磁共振扫描仪和第二模态成像系统之间的间隙中，并且包括可选择性地移动到用于磁共振成像的磁共振扫描仪的检查区域中的线性可平移的患者支撑托盘， 进入用于第二模态成像的第二模态成像系统的检查区域。 在一些实施例中，线性平移托盘的线性平移范围小于患者支撑托盘沿线性平移方向的长度的五倍。

公开(公告)号：US08460549B2

公开(公告)日：2013-06-11

申请号：US11434764

申请日：2006-05-17

申请人： Harold E. Haney ,  Robert Freeman ,  Rodrigo Lobo Morales ,  Daniel Gagnon

发明人： Harold E. Haney ,  Robert Freeman ,  Rodrigo Lobo Morales ,  Daniel Gagnon

IPC分类号： C02F1/20

CPC分类号： C02F1/34 ,  C02F1/727 ,  C02F1/74 ,  C02F3/00 ,  C02F9/00 ,  C02F11/00 ,  C02F2001/007 ,  C02F2301/066 ,  C02F2303/06

摘要： An apparatus for treating an aqueous medium containing microorganisms comprises an intake for receiving the aqueous medium containing microorganisms. A pressure differential inducer is associated to the intake so as to receive the aqueous medium containing microorganisms with a desired level of gas saturation. The pressure differential inducer is actuatable to expose the aqueous medium containing microorganisms with a desired level of gas saturation to accelerations so as to cause cell wall rupture of the microorganisms. An outlet is associated with the pressure differential inducer for outletting the treated aqueous medium containing ruptured microorganism cells and contents. The treated aqueous medium containing ruptured cell wall of the microorganisms is disposed of and/or recycled.

摘要翻译： 用于处理含有微生物的水性介质的装置包括用于接收含有微生物的水性介质的摄取元件。 压差诱导剂与进食相关联，以便接收含有所需水分气体饱和度的微生物的水性介质。 压差诱导剂可致动以将含有所需水平的气体饱和的微生物的含水介质暴露于加速度，从而引起微生物的细胞壁破裂。 出口与用于出口含有破裂的微生物细胞和内容物的经处理的水性介质的压差诱导剂相关联。 含有微生物破裂的细胞壁的经处理的水性介质被处理和/或再循环。

公开(公告)号：US08378305B2

公开(公告)日：2013-02-19

申请号：US12935302

申请日：2009-03-20

申请人： Daniel Gagnon ,  Douglas B. McKnight

发明人： Daniel Gagnon ,  Douglas B. McKnight

IPC分类号： G01T1/20

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01R33/481

摘要： When performing positron emission tomography (PET) scanning and image reconstruction, a primary PET system (10) with a primary PET detector array (12) is used to image a patient or subject, and a secondary PET detector array (14) is coupled to the system at specific input points to mitigate unnecessary duplication of system components. The primary system (10) provides PET data processing and reconstruction for the secondary array (14), in addition to the first array (12). An adjustable array (120) includes radially movable detectors (122) and stationary detectors (124) with different crystal resolutions. The movable detectors (122) are alternately positioned with the stationary detectors (124) at a first radius to form a large detector ring, or are positioned at a second, smaller radius without the stationary detectors (124) to form a small detector ring.

摘要翻译： 当进行正电子发射断层扫描（PET）扫描和图像重建时，使用具有主要PET检测器阵列（12）的主要PET系统（10）对患者或受试者进行成像，并且将辅助PET检测器阵列（14）耦合到 该系统在特定的输入点，以减轻不必要的系统组件重复。 除了第一阵列（12）之外，主系统（10）还为次级阵列（14）提供PET数据处理和重建。 可调节阵列（120）包括具有不同晶体分辨率的径向可移动探测器（122）和固定探测器（124）。 移动检测器（122）与第一半径处的固定式检测器（124）交替定位以形成大的检测器环，或者定位在第二较小的半径处，而没有固定的检测器（124）以形成小的检测器环。