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1.发明授权公开(公告)号：US06875184B2
公开(公告)日：2005-04-05
申请号：US10072538
申请日：2002-02-08
CPC分类号： A61B5/6834 , A61B10/0041 , A61B10/0045 , A61B10/0283 , A61M1/06 , A61M1/064 , A61M1/066 , A61M2205/3653
摘要： Disclosed is a method and apparatus for accomplishing a noninvasive screen for breast disease markers, including breast cancer markers and cytologically abnormal cells. Intraductal fluid is noninvasively aspirated using compression, heating and suction cycles. The removed sample is thereafter assayed for the presence of cytologically abnormal cells and/or one or more breast disease markers. In addition to the diagnostic applications of the disclosed method and apparatus, a therapeutic application is also contemplated wherein intraductal fluids are noninvasively aspirated using compression, heating and suction cycles to remove toxic buildups within the fluid.
摘要翻译： 公开了一种用于完成乳腺疾病标志物（包括乳腺癌标志物和细胞学异常细胞）的非侵入性筛查的方法和装置。 使用压缩，加热和抽吸循环非导管式吸入导管内液体。 然后检测去除的样品是否存在细胞学异常细胞和/或一种或多种乳腺疾病标记物。 除了所公开的方法和装置的诊断应用之外，还考虑了治疗应用，其中使用压缩，加热和抽吸循环非侵入式吸入导管内流体以去除流体内的毒性积聚。
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公开(公告)号：US06712785B2
公开(公告)日：2004-03-30
申请号：US10072539
申请日：2002-02-08
IPC分类号： A61M100
CPC分类号： A61B5/6834 , A61B10/0041 , A61B10/0045 , A61B10/0283 , A61M1/06 , A61M1/064 , A61M1/066 , A61M2205/3653
摘要： A method is disclosed for noninvasively obtaining intraductal fluid. The method includes the use of an intraductal fluid sampling device to contact the patient, provide compression, and deliver heat thereto according to predetermined cycle characteristics. The cycle characteristics, such as compression cycle times and compression rates, may be varied and controlled by a control circuit.
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公开(公告)号：US07575557B2
公开(公告)日：2009-08-18
申请号：US10072543
申请日：2002-02-08
CPC分类号： A61B5/6834 , A61B10/0041 , A61B10/0045 , A61B10/0283 , A61M1/06 , A61M1/064 , A61M1/066 , A61M2205/3653
摘要： Disclosed is a disposable closed fluid loop for providing heat and compression to an intraductal fluid aspiration device. A plurality of bladders are configured to receive a pressurized inflation fluid, and to inflate in response thereto. The fluid is further configured to flow adjacent a heat exchanger, thereby receiving thermal energy, which it imparts to the bladders through conduction. Accordingly, the disclosed fluid loop provides heated inflation media to inflate a plurality of bladders to provide heat and compression to an intraductal fluid aspiration patient.
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4.发明授权公开(公告)号：US07468043B2
公开(公告)日：2008-12-23
申请号：US11099295
申请日：2005-04-05
CPC分类号： A61B5/6834 , A61B10/0041 , A61B10/0045 , A61B10/0283 , A61M1/06 , A61M1/064 , A61M1/066 , A61M2205/3653
摘要： Disclosed is a method and apparatus for accomplishing a noninvasive screen for breast disease markers, including breast cancer markers and cytologically abnormal cells. Intraductal fluid is noninvasively aspirated using compression, heating and suction cycles. The removed sample is thereafter assayed for the presence of cytologically abnormal cells and/or one or more breast disease markers. In addition to the diagnostic applications of the disclosed method and apparatus, a therapeutic application is also contemplated wherein intraductal fluids are noninvasively aspirated using compression, heating and suction cycles to remove toxic buildups within the fluid.
摘要翻译： 公开了一种用于完成乳腺疾病标志物（包括乳腺癌标志物和细胞学异常细胞）的非侵入性筛查的方法和装置。 使用压缩，加热和抽吸循环非导管式吸入导管内液体。 然后检测去除的样品是否存在细胞学异常细胞和/或一种或多种乳腺疾病标记物。 除了所公开的方法和装置的诊断应用之外，还考虑了治疗应用，其中使用压缩，加热和抽吸循环非侵入式吸入导管内流体以去除流体内的毒性积聚。
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公开(公告)号：US06676610B2
公开(公告)日：2004-01-13
申请号：US10072546
申请日：2002-02-08
IPC分类号： A61B500
CPC分类号： A61B5/6834 , A61B10/0041 , A61B10/0045 , A61B10/0283 , A61M1/06 , A61M1/064 , A61M1/066 , A61M2205/3653
摘要： Disclosed is a disposable patient interface for an intraductal fluid aspiration system. The interface has a flexible tubular distal member for contacting the patient, and a rigid proximal member forming a vacuum chamber therein. The rigid member has a vacuum aperture for communication with a source of vacuum. The flexible member preferably has a low modulus of elasticity and a high tear strength, such that it can be stretched to fit over a rigid support without rupture.
摘要翻译： 公开了用于管内液体抽吸系统的一次性患者接口。 界面具有用于接触患者的柔性管状远端构件和在其中形成真空室的刚性近端构件。 刚性构件具有用于与真空源连通的真空孔。 柔性构件优选地具有低的弹性模量和高的撕裂强度，使得其可被拉伸以配合在刚性支撑件上而不破裂。
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公开(公告)号：US20110118627A1
公开(公告)日：2011-05-19
申请号：US13014424
申请日：2011-01-26
IPC分类号： A61B5/00
CPC分类号： A61B10/0045 , A61B5/4288 , A61B5/4312 , A61B5/6834 , A61B10/0041 , A61B10/0283 , A61B17/42 , A61B2017/0023 , A61B2017/00473 , A61B2017/00862 , A61M1/064 , A61M1/066 , A61M2205/3653
摘要： Disclosed is a disposable patient interface for an intraductal fluid aspiration system. The interface has a flexible tubular distal member for contacting the patient, and a proximal support portion forming a vacuum chamber therein. The support portion has a vacuum aperture for communication with a source of vacuum, and a retention structure for releasably mounting within a hand piece of an intraductal fluid aspiration system. The flexible member preferably has a low modulus of elasticity and a high tear strength, such that it can be stretched to fit over a rigid support without rupture.
摘要翻译： 公开了用于管内液体抽吸系统的一次性患者接口。 界面具有用于接触患者的柔性管状远端构件和在其中形成真空室的近端支撑部分。 支撑部分具有用于与真空源连通的真空孔，以及用于可释放地安装在管内液体抽吸系统的手部件内的保持结构。 柔性构件优选地具有低的弹性模量和高的撕裂强度，使得其可被拉伸以配合在刚性支撑件上而不破裂。
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公开(公告)号：US06981950B2
公开(公告)日：2006-01-03
申请号：US10072537
申请日：2002-02-08
CPC分类号： A61B5/6834 , A61B10/0041 , A61B10/0045 , A61B10/0283 , A61M1/06 , A61M1/064 , A61M1/066 , A61M2205/3653
摘要： Disclosed is an apparatus for noninvasive intraductal fluid aspiration. Intraductal fluid is noninvasively aspirated using compression, heating and suction cycles. The device is configured to provide a compression force, deliver heat, and apply a vacuum pressure to encourage the aspiration of patient fluid. The device includes an adjustable support and a movable wall for applying compression. Withdrawn fluid may be used either for diagnostic or therapeutic purposes.
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公开(公告)号：US06899696B2
公开(公告)日：2005-05-31
申请号：US10811762
申请日：2004-03-29
CPC分类号： A61B5/6834 , A61B10/0041 , A61B10/0045 , A61B10/0283 , A61M1/06 , A61M1/064 , A61M1/066 , A61M2205/3653
摘要： A method is disclosed for noninvasively obtaining intraductal fluid. The method includes the use of an intraductal fluid sampling device to contact the patient, provide compression, and deliver heat thereto according to predetermined cycle characteristics. The cycle characteristics, such as compression cycle times and compression rates, may be varied and controlled by a control circuit.
摘要翻译： 公开了一种非侵入式获得导管内液体的方法。 该方法包括根据预定的循环特征使用导管内液体取样装置接触患者，提供压缩并将热量传递给患者。 诸如压缩循环时间和压缩速率的循环特性可以由控制电路改变和控制。
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9.发明申请公开(公告)号：US20080015495A1
公开(公告)日：2008-01-17
申请号：US11775751
申请日：2007-07-10
申请人： Kevin Morton , Rex Bare , Jeffrey Smith , Timothy Payne , Paul Gleason
发明人： Kevin Morton , Rex Bare , Jeffrey Smith , Timothy Payne , Paul Gleason
IPC分类号： A61M1/06
CPC分类号： A61B5/6834 , A61B10/0041 , A61B10/0045 , A61B10/0283 , A61M1/06 , A61M1/064 , A61M1/066 , A61M2205/3653
摘要： Disclosed is a method and apparatus for accomplishing a noninvasive screen for breast disease markers, including breast cancer markers and cytologically abnormal cells. Intraductal fluid is noninvasively aspirated using compression, heating and suction cycles. The removed sample is thereafter assayed for the presence of cytologically abnormal cells and/or one or more breast disease markers. In addition to the diagnostic applications of the disclosed method and apparatus, a therapeutic application is also contemplated wherein intraductal fluids are noninvasively aspirated using compression, heating and suction cycles to remove toxic buildups within the fluid.
摘要翻译： 公开了一种用于完成乳腺疾病标志物（包括乳腺癌标志物和细胞学异常细胞）的非侵入性筛查的方法和装置。 使用压缩，加热和抽吸循环非导管式吸入导管内液体。 然后检测去除的样品是否存在细胞学异常细胞和/或一种或多种乳腺疾病标记物。 除了所公开的方法和装置的诊断应用之外，还考虑了治疗应用，其中使用压缩，加热和抽吸循环非侵入式吸入导管内流体以去除流体内的毒性积聚。
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公开(公告)号：US20080015469A1
公开(公告)日：2008-01-17
申请号：US11775768
申请日：2007-07-10
申请人： Kevin Morton , Rex Bare , Jeffrey Smith , Timothy Payne , Paul Gleason
发明人： Kevin Morton , Rex Bare , Jeffrey Smith , Timothy Payne , Paul Gleason
IPC分类号： A61B10/02
CPC分类号： A61B10/0045 , A61B5/4288 , A61B5/4312 , A61B5/6834 , A61B10/0041 , A61B10/0283 , A61B17/42 , A61B2017/0023 , A61B2017/00473 , A61B2017/00862 , A61M1/064 , A61M1/066 , A61M2205/3653
摘要： Disclosed is a disposable patient interface for an intraductal fluid aspiration system. The interface has a flexible tubular distal member for contacting the patient, and a proximal support portion forming a vacuum chamber therein. The support portion has a vacuum aperture for communication with a source of vacuum, and a retention structure for releasably mounting within a hand piece of an intraductal fluid aspiration system. The flexible member preferably has a low modulus of elasticity and a high tear strength, such that it can be stretched to fit over a rigid support without rupture.
摘要翻译： 公开了用于管内液体抽吸系统的一次性患者接口。 界面具有用于接触患者的柔性管状远端构件和在其中形成真空室的近端支撑部分。 支撑部分具有用于与真空源连通的真空孔，以及用于可释放地安装在管内液体抽吸系统的手部件内的保持结构。 柔性构件优选地具有低的弹性模量和高的撕裂强度，使得其可被拉伸以配合在刚性支撑件上而不破裂。
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