摘要:
There is provided compounds having the formula of structure I: wherein the groups —C(R8)(CH2)vCH(R9)(CH2)y-Q and —C(R8)(CH2)vCH(R9)(CH2)y-J are the same, and R1a, R1b, R2a, R2b, R8, R9, J, Q, W, X, L2, v and y have meanings given in the description. The use of such compounds in the treatment of a condition responsive to changes in melanocortin receptor function in a human or non-human mammal (e.g. male sexual dysfunction, female sexual dysfunction, an eating disorder, above optimal body weight, obesity, below-optimal body weight or cachexia) is also described.
摘要:
A method of modulating energy homeostasis in a mammal without eliciting a sexual response by administration of a therapeutically effective amount of a pharmaceutical composition including a melanocortin receptor compound of the formula: where R1 is a bond or a linker unit including from one to six backbone atoms and an unsubstituted naphthalene group, and L, R2, R3 and Rx are as defined in the specification.
摘要翻译:一种通过施用治疗有效量的药物组合物来调节哺乳动物的能量稳态的方法,其不引起性反应,所述药物组合物包括下式的黑皮质素受体化合物:其中R 1是键或连接基 包含1至6个骨架原子和未取代的萘基的单元,以及L,R 2,R 3和R x x定义如 规格。
摘要:
There is provided compounds having the formula of structure I: wherein the groups —C(R8)(CH2)vCH(R9)(CH2)y-Q and —C(R8)(CH2)vCH(R9)(CH2)y-J are the same, and R1a, R1b, R2a, R2b, R8, R9, J, Q, W, X, L2, v and y have meanings given in the description. Thus use of such compounds in the treatment of a condition responsive to changes in melanocortin receptor function in a human or non-human mammal (e.g. male sexual dysfunction, female sexual dysfunction, an eating disorder, above optimal body weight, obesity, below-optimal body weight or cachexia) is also described.
摘要翻译:提供具有结构式I的化合物:其中基团-C(R 8)(CH 2)2 CH(R' (CH 2)n(CH 2)n(CH 2)q(CH 2) (CH 2))CH(R 9)(CH 2)n Y -J相同,和 R 1a,R 1b,R 2a,R 2b,R 8,R 8, R 9,J,Q,W,X,L 2,v和y具有在说明书中给出的含义。 因此,使用这些化合物治疗对人或非人哺乳动物(例如男性性功能障碍,女性性功能障碍,进食障碍,超过最佳体重,肥胖,低于最佳)的黑色素皮质素受体功能变化的病症 体重或恶病质)也被描述。
摘要:
A highly selective melanocortin-4 receptor antagonist cyclic hexapeptide of the formula where R1, R2, R3a, R3b, R4, R5, x, y and z are as defined in the specification, and a method of treating body weight disorders, including cachexia, sarcopenia and wasting syndrome or disease, and treating inflammation and immune disorders.
摘要翻译:具有下式的高选择性黑皮质素-4受体拮抗剂环状六肽其中R 1,R 2,R 3a,R 3b, R 3,R 5,R 5,x,y和z如说明书中所定义,以及治疗体重紊乱的方法,包括恶病质,肌肉减少症和 浪费综合征或疾病,以及治疗炎症和免疫疾病。
摘要:
A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formula where R1, R2, R3, R4a, R4b, R5, R6, R7, x, y and z are as defined in the specification, and a method of treating body weight disorders, including cachexia, sarcopenia and wasting syndrome or disease, and treating inflammation and immune disorders.