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1.发明授权Liquid chalcogenide compositions and methods of manufacturing and using the same 有权液体硫族化合物组合物及其制备和使用方法公开(公告)号：US07923037B2
公开(公告)日：2011-04-12
申请号：US12023840
申请日：2008-01-31
CPC分类号： A61K33/04 , A61J1/06 , A61K9/0019 , A61K9/08 , A61K33/00 , A61K33/24 , A61K47/02 , A61K47/12 , B65D81/2069
摘要： The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
摘要翻译： 本发明提供包含硫族化合物或其盐的新型稳定的液体组合物。 这些组合物可以用于各种目的，包括治疗和预防缺血性或缺氧性损伤以及保护生物物质。
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公开(公告)号：US20110162994A1
公开(公告)日：2011-07-07
申请号：US13049227
申请日：2011-03-16
CPC分类号： A61K33/04 , A61J1/06 , A61K9/0019 , A61K9/08 , A61K33/00 , A61K33/24 , A61K47/02 , A61K47/12 , B65D81/2069
摘要： The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
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3.发明申请Liquid Chalcogenide Compositions and Methods of Manufacturing and Using the Same 有权液态硫族化合物组合物及其制造和使用方法公开(公告)号：US20110165268A1
公开(公告)日：2011-07-07
申请号：US13049220
申请日：2011-03-16
CPC分类号： A61K33/04 , A61J1/06 , A61K9/0019 , A61K9/08 , A61K33/00 , A61K33/24 , A61K47/02 , A61K47/12 , B65D81/2069
摘要： The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
摘要翻译： 本发明提供包含硫族化合物或其盐的新型稳定的液体组合物。 这些组合物可以用于各种目的，包括治疗和预防缺血性或缺氧性损伤以及保护生物物质。
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公开(公告)号：US20080199541A1
公开(公告)日：2008-08-21
申请号：US12023840
申请日：2008-01-31
CPC分类号： A61K33/04 , A61J1/06 , A61K9/0019 , A61K9/08 , A61K33/00 , A61K33/24 , A61K47/02 , A61K47/12 , B65D81/2069
摘要： The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
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5.发明申请LIQUID CHALCOGENIDE COMPOSITIONS AND METHODS OF MANUFACTURING AND USING THE SAME 审中-公开液体氯化铝组合物及其制备方法和使用方法公开(公告)号：US20080187604A1
公开(公告)日：2008-08-07
申请号：US11868348
申请日：2007-10-05
CPC分类号： A61K33/04 , A61K9/0095 , A61K9/2013 , A61K9/2054
摘要： The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
摘要翻译： 本发明提供包含硫族化合物或其盐的新型稳定的液体组合物。 这些组合物可以用于各种目的，包括治疗和预防缺血性或缺氧性损伤以及保护生物物质。
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6.发明授权Liquid chalcogenide compositions and methods of manufacturing and using the same 有权液体硫族化合物组合物及其制备和使用方法公开(公告)号：US08226986B2
公开(公告)日：2012-07-24
申请号：US13049220
申请日：2011-03-16
CPC分类号： A61K33/04 , A61J1/06 , A61K9/0019 , A61K9/08 , A61K33/00 , A61K33/24 , A61K47/02 , A61K47/12 , B65D81/2069
摘要： The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
摘要翻译： 本发明提供包含硫族化合物或其盐的新型稳定的液体组合物。 这些组合物可以用于各种目的，包括治疗和预防缺血性或缺氧性损伤以及保护生物物质。
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7.发明授权Inhibition of apoptosis using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors 失效使用白细胞介素-1β转换酶（ICE）/ CED-3家族抑制剂抑制细胞凋亡公开(公告)号：US06528506B2
公开(公告)日：2003-03-04
申请号：US10083862
申请日：2002-02-25
IPC分类号： A61K3155
CPC分类号： A61K31/404 , A01N1/0226 , A61K38/55 , C07K5/0202
摘要： The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viablility of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.
摘要翻译： 本发明提供了使用白细胞介素-1β转换酶（ICE）/ CED-3家族抑制剂扩增和增加造血细胞群的存活，延长移植器官的可行性以及增强生物生产的方法。 本文提供了可用于本发明方法的示例性化合物。
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公开(公告)号：US06525024B1
公开(公告)日：2003-02-25
申请号：US09837614
申请日：2001-04-17
IPC分类号： C07K506
CPC分类号： C07C311/51
摘要： This invention is directed to novel sulfonimide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, X, R, R1, R2, n, q, and r are as defined herein. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
摘要翻译： 本发明涉及具有以下结构的新型磺酰亚胺（取代）酰基二肽基ICE / ced-3家族抑制剂化合物：其中A，B，X，R，R 1，R 2，n，q和r如本文所定义。 本发明还涉及含有这些化合物的药物组合物，以及这些组合物在治疗患有炎症，自身免疫和神经变性疾病的患者中的用途，用于预防缺血性损伤以及用于保存经受的器官 移植手术。
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公开(公告)号：US06515173B1
公开(公告)日：2003-02-04
申请号：US09482813
申请日：2000-01-13
IPC分类号： C07K506
CPC分类号： C07K5/06191 , A61K38/00 , C07C311/51 , C07K5/06026 , C07K5/06034 , C07K5/06078
摘要： This invention s directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, p and q are as defined herein. The invention s all directed to pharmaceutical compositions containing one or more of thee compound, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that to undergo a transplantation procedure.
摘要翻译： 本发明涉及具有以下结构的新型草酰二肽ICE / ced-3家族抑制剂化合物：其中A，B，R，R 1，p和q如本文所定义。 本发明全部涉及含有一种或多种化合物的药物组合物，以及这些组合物在治疗患有炎症，自身免疫和神经变性疾病的患者中的用途，用于预防缺血性损伤和用于保护 要进行移植手术的器官。
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公开(公告)号：US06790989B2
公开(公告)日：2004-09-14
申请号：US09908969
申请日：2001-07-18
IPC分类号： C07K506
CPC分类号： C07C311/51 , A61K38/05 , C07K5/0202
摘要： This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, R, R1, R1′ p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmnune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
摘要翻译： 本发明涉及具有以下结构的新型恶草二肽ICE / ced-3家族抑制剂化合物：其中A，B，R，R 1，R 1，p和q如本文所定义。 本发明还涉及含有这些化合物中的一种或多种的药物组合物，以及这些组合物在治疗患有炎性，自身免疫和神经变性疾病的患者中的用途，用于预防缺血性损伤和用于保护 要进行移植手术的器官。
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