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公开(公告)号：US20100080791A1
公开(公告)日：2010-04-01
申请号：US12238991
申请日：2008-09-26
CPC分类号： A61L27/48 , A61L27/446 , A61L27/50
摘要： The present invention provides a composition and method for treating tissue defects. The composition includes thrombin and fibrinogen, or sodium alginate and calcium chloride, and also a surfactant, and non-resorbable polymer microparticles dispersed within the composition.
摘要翻译： 本发明提供了治疗组织缺陷的组合物和方法。 组合物包括凝血酶和纤维蛋白原，藻酸钠和氯化钙，以及分散在组合物内的表面活性剂和不可再吸收的聚合物微粒。
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公开(公告)号：US08800567B2
公开(公告)日：2014-08-12
申请号：US12578271
申请日：2009-10-13
IPC分类号： A61F5/37 , A61F5/56 , A61C5/14 , A61B19/00 , A61F2/20 , A61F2/02 , A61F2/08 , A61B17/56 , A61B17/70
CPC分类号： A61F5/56 , A61B2017/00557 , A61B2017/0404 , A61B2017/0417 , A61B2017/06176 , A61F2/00 , A61F2/0063 , A61F5/566
摘要： A system, method and kit for treating obstructive sleep apnea. The system includes a first implant adapted for implantation in an inframandibular region and having at least one aperture therethrough, and a ribbon-like element having first and second ends and a substantially uniform, non-circular cross section along its length. The ribbon-like element is adapted for implantation in a tongue with the first and second ends extending through the at least one aperture in the first implant for coupling the ribbon-like element with the first implant.
摘要翻译： 一种用于治疗阻塞性睡眠呼吸暂停的系统，方法和试剂盒。 该系统包括适于植入在下颌下区域并且具有穿过其中的至少一个孔的第一植入物，以及具有沿其长度的第一端和第二端以及基本均匀的非圆形截面的带状元件。 带状元件适于植入舌头中，第一和第二端延伸穿过第一植入物中的至少一个孔，用于将带状元件与第一植入物联接。
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公开(公告)号：US20130186412A1
公开(公告)日：2013-07-25
申请号：US13790509
申请日：2013-03-08
IPC分类号： A61F5/56
CPC分类号： A61F5/56 , A61B2017/00557 , A61B2017/0404 , A61B2017/0417 , A61B2017/06176 , A61F2/00 , A61F2/0063 , A61F5/566
摘要： A system, method and kit for treating obstructive sleep apnea. The system includes a first implant adapted for implantation in an inframandibular region and having at least one aperture therethrough, and a ribbon-like element having first and second ends and a substantially uniform, non-circular cross section along its length. The ribbon-like element is adapted for implantation in a tongue with the first and second ends extending through the at least one aperture in the first implant for coupling the ribbon-like element with the first implant.
摘要翻译： 一种用于治疗阻塞性睡眠呼吸暂停的系统，方法和试剂盒。 该系统包括适于植入在下颌下区域并且具有穿过其中的至少一个孔的第一植入物，以及具有沿其长度的第一端和第二端以及基本均匀的非圆形截面的带状元件。 带状元件适于植入舌头中，第一和第二端延伸穿过第一植入物中的至少一个孔，用于将带状元件与第一植入物联接。
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公开(公告)号：US20120225052A1
公开(公告)日：2012-09-06
申请号：US13470873
申请日：2012-05-14
CPC分类号： A61L27/48 , A61L27/446 , A61L27/50
摘要： The present invention provides a composition and method for treating tissue defects. The composition includes thrombin and fibrinogen, or sodium alginate and calcium chloride, and also a surfactant, and non-resorbable polymer microparticles dispersed within the composition.
摘要翻译： 本发明提供了治疗组织缺陷的组合物和方法。 组合物包括凝血酶和纤维蛋白原，藻酸钠和氯化钙，以及分散在组合物内的表面活性剂和不可再吸收的聚合物微粒。
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公开(公告)号：US08561617B2
公开(公告)日：2013-10-22
申请号：US12261102
申请日：2008-10-30
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A method of treating obstructive sleep apnea includes providing an elongated element having a central buttress area and first and second arms extending from opposite ends of the central buttress area. The method includes implanting the central buttress area in a tongue so that a longitudinal axis of the central buttress area intersects an anterior-posterior axis of the tongue. The first and second arms are advanced through the tongue until the first and second arms engage inframandibular musculature. Tension is applied to the first and second arms for pulling the central buttress area toward the inframandibular musculature for moving a posterior surface of the tongue away from an opposing surface of a pharyngeal wall. The first and second arms are anchored to the inframandibular musculature for maintaining a space between the posterior surface of the tongue and the opposing surface of the pharyngeal wall.
摘要翻译： 治疗阻塞性睡眠呼吸暂停的方法包括提供具有中心支撑区域的细长元件和从中心支撑区域的相对端部延伸的第一和第二臂。 该方法包括将中心支撑区域植入舌部，使得中央支撑区域的纵向轴线与舌头的前后轴线相交。 第一和第二臂通过舌头前进，直到第一和第二臂与下颌下肌肉组织接合。 将张力施加到第一和第二臂上，用于将中央支撑区域拉向下颌下肌肉组织，以将舌的后表面远离咽壁的相对表面移动。 第一和第二臂被锚固到下颌骨肌肉组织，以保持舌的后表面和咽壁的相对表面之间的空间。
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6.发明申请TONGUE SUSPENSION SYSTEM WITH HYOID-EXTENDER FOR TREATING OBSTRUCTIVE SLEEP APNEA 有权用于治疗阻塞性睡眠障碍的超声剂延迟系统公开(公告)号：US20110100377A1
公开(公告)日：2011-05-05
申请号：US12608168
申请日：2009-10-29
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A system for treating obstructive sleep apnea includes a first element implantable in a tongue and a second element implantable between muscle planes of an inframandibular region. The second element has a first end coupled with the first element and a second end coupled with a hyoid bone for preventing the base of the tongue from collapsing against an opposing pharyngeal wall during sleep. The first and second implantable elements have outer surfaces that are substantially impermeable to tissue in-growth to allow for post-surgical adjustment or removal, if necessary. The first implantable element is elongated and includes a first end, a second end, and a center section located between the first and second ends. The center section is implantable in the tongue, and the first and second ends of the first implantable element are advanceable beneath the tongue for being coupled with the anterior end of the second implantable element.
摘要翻译： 用于治疗阻塞性睡眠呼吸暂停的系统包括可植入舌头的第一元件和可植入在下颌下区域的肌肉平面之间的第二元件。 第二元件具有与第一元件相结合的第一端和与舌骨相连的第二端，用于防止舌头的基部在睡眠期间塌陷在相对的咽壁上。 第一和第二可植入元件具有外表面，其对组织生长进行基本上是不可渗透的，以便在需要时进行手术后调整或移除。 第一可植入元件是细长的并且包括第一端部，第二端部和位于第一端部和第二端部之间的中心部分。 中心部分可植入舌部，并且第一可植入元件的第一和第二端可在舌下方前进，以与第二可植入元件的前端相连。
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7.发明授权Methods and devices for the indirect displacement of the hyoid bone for treating obstructive sleep apnea 有权舌骨间接移位用于治疗阻塞性睡眠呼吸暂停的方法和装置公开(公告)号：US08561616B2
公开(公告)日：2013-10-22
申请号：US12257563
申请日：2008-10-24
CPC分类号： A61F5/566
摘要： An implant for treating obstructive sleep apnea includes an elongated body having a central region, a first end, and a second end opposite the first end. The central region of the elongated body engages inframandibular musculature that extends between a mandible and a hyoid bone. The first and second ends of the elongated body are optionally anchored to the mandible. The elongated body is under tension for urging the inframandibular musculature in an inferior direction, which, in turn, pulls the hyoid bone anteriorly for minimizing the likelihood of occurrence of obstructive sleep apnea episodes.
摘要翻译： 用于治疗阻塞性睡眠呼吸暂停的植入物包括具有中心区域，第一端和与第一端相对的第二端的细长体。 细长体的中心区域接合在下颌骨和舌骨之间延伸的下颌骨肌肉组织。 细长体的第一和第二端可选地被锚定到下颌骨。 细长的身体处于紧张状态，用于沿较低的方向推动下颌骨肌肉组织，这又反过来拉动舌骨前方以最小化发生阻塞性睡眠呼吸暂停发作的可能性。
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公开(公告)号：US20130174857A1
公开(公告)日：2013-07-11
申请号：US13784077
申请日：2013-03-04
IPC分类号： A61F5/56
摘要： A pharyngeal retractor device and implantation methods are provided for use in the treatment of obstructive sleep apnea. The device includes a retracting element and a tissue engaging element that promotes tissue ingrowth around or onto the retracting element. The device is implanted in tissue space beneath the pharyngeal wall to alter the shape of the wall. The device may be implanted through the oral cavity alone or by using a trocar or a hand-held delivery system to deliver the device through the pharyngeal wall. Alternatively, the device may be implanted using an open, direct visualization approach from the side of a patient's neck.
摘要翻译： 提供咽收缩器装置和植入方法用于治疗阻塞性睡眠呼吸暂停。 该装置包括回缩元件和组织接合元件，其促进组织向内生长在收缩元件周围或上。 该装置植入咽壁下方的组织空间以改变壁的形状。 该装置可以单独地通过口腔植入，或者通过使用套管针或手持递送系统将装置输送通过咽壁。 或者，可以使用来自患者颈部侧面的开放的直接可视化方法来植入该装置。
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公开(公告)号：US20100132719A1
公开(公告)日：2010-06-03
申请号：US12325350
申请日：2008-12-01
CPC分类号： A61F5/566
摘要： A system for treating obstructive sleep apnea includes an anchoring element having scar tissue located in an inframandibular region, and a tongue implant having at least one arm extending therefrom, whereby the tongue implant is implantable in a tongue with the at least one arm being connectable with the anchoring element for coupling the tongue implant with the anchoring element. In one embodiment, the anchoring element includes a first implant part such as a flexible layer implantable in the inframandibular region and the scar tissue is formed on, in, and/or around the first implant part. The tongue implant is coupled with the anchoring element and/or the scar tissue through the at least one arm. The length of the at least one arm may be adjusted for shifting the tongue anteriorly.
摘要翻译： 用于治疗阻塞性睡眠呼吸暂停的系统包括具有位于下颌区域中的瘢痕组织的锚定元件和具有从其延伸的至少一个臂的舌植入物，由此所述舌植入物可植入舌头中，所述至少一个臂可与 用于将舌植入物与锚定元件联接的锚固元件。 在一个实施例中，锚定元件包括第一植入部分，例如可植入在下颌下区域中的柔性层，并且瘢痕组织形成在第一植入部分上，内和/或周围。 舌植入物通过至少一个臂与锚定元件和/或瘢痕组织联接。 可以调节至少一个臂的长度以使舌头向前移动。
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公开(公告)号：US09687262B2
公开(公告)日：2017-06-27
申请号：US11290780
申请日：2005-11-30
CPC分类号： A61B17/22 , A61B17/00491 , A61B17/12022 , A61B17/12136 , A61B17/12181 , A61B2017/00893 , A61B2017/22082 , A61M25/1002
摘要： This invention provides methods, devices and kits for treating coronary artery disease, particularly “soft” or vulnerable plaque. The invention is based on the local delivery of crosslinking means to crosslink the collagen covering the plaque and other proteins that may be present at the site to stabilize the plaque and prevent leakage of thrombogenic material into the lumen of the coronary artery. In certain embodiments, catheters are employed to achieve local delivery of a crosslinking agent or ultraviolet light.
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