公开(公告)号：US06348570B1

公开(公告)日：2002-02-19

申请号：US07808994

申请日：1991-12-17

申请人： Kevin T. Chapman ,  Malcolm Maccoss ,  Richard A. Mumford ,  Nancy A. Thornberry ,  Jeffrey R. Weidner ,  William K. Hagmann

发明人： Kevin T. Chapman ,  Malcolm Maccoss ,  Richard A. Mumford ,  Nancy A. Thornberry ,  Jeffrey R. Weidner ,  William K. Hagmann

IPC分类号： A61K3804

CPC分类号： C07K5/1016 ,  C07K14/545

摘要： Disclosed are novel chromophore containing compounds of Formula I and their use in determining interleukin-1&bgr; convertase (ICE) activity. ICE has been implicated in inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes.

摘要翻译： 公开了含有式I化合物的新颖发色团及其在测定白细胞介素-1β转化酶（ICE）活性中的用途。 ICE已经涉及肺和气道的炎性或免疫性疾病; 中枢神经系统和周围膜; 眼睛和耳朵 关节，骨骼和结缔组织; 包括心包的心血管系统; 胃肠道和泌尿生殖系统; 皮肤和粘膜。

公开(公告)号：US5434248A

公开(公告)日：1995-07-18

申请号：US70483

申请日：1993-06-02

申请人： Kevin T. Chapman ,  Herb G. Bull ,  Malcolm MacCoss ,  Nancy A. Thornberry ,  Jeffrey R. Weidner ,  Adnan M. Mjalli

发明人： Kevin T. Chapman ,  Herb G. Bull ,  Malcolm MacCoss ,  Nancy A. Thornberry ,  Jeffrey R. Weidner ,  Adnan M. Mjalli

IPC分类号： A61K38/55 ,  A61P11/00 ,  A61P29/00 ,  C07C233/47 ,  C07C233/51 ,  C07C237/22 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K17/00

CPC分类号： C07K5/0202 ,  C07C233/47 ,  C07C233/51

摘要： Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. ##STR1##