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    Peptidyl derivatives as inhibitors of interleukin-1.beta. converting enzyme
    7.
    发明授权
    Peptidyl derivatives as inhibitors of interleukin-1.beta. converting enzyme 失效
    肽基衍生物作为白细胞介素-1β转换酶的抑制剂

    公开(公告)号：US5430128A

    公开(公告)日：1995-07-04

    申请号：US342991

    申请日：1994-11-21

    申请人： Kevin T. Chapman ,  Malcolm MacCoss ,  Adnan Mjalli

    发明人： Kevin T. Chapman ,  Malcolm MacCoss ,  Adnan Mjalli

    IPC分类号： A61K38/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K5/00 ,  C07K7/00 ,  C07K17/00

    CPC分类号： C07K5/0202 ,  A61K38/00

    摘要： Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. ##STR1##

    摘要翻译： 发现式I的新型肽基衍生物是白细胞介素-1β转换酶（ICE）的有效抑制剂。 式I化合物可用于治疗肺和气道炎性或免疫性疾病; 中枢神经系统和周围膜; 眼睛和耳朵 关节，骨骼和结缔组织; 包括心包的心血管系统; 胃肠道和泌尿生殖系统; 皮肤和粘膜。 式I化合物也可用于治疗感染（例如，革兰氏阴性休克）的并发症和其中IL1作为自分泌生长因子或作为恶病质介质的肿瘤。

    Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
    10.
    发明申请
    Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase 审中-公开
    核苷衍生物作为rna依赖性rna病毒聚合酶的抑制剂

    公开(公告)号：US20060234962A1

    公开(公告)日：2006-10-19

    申请号：US10517294

    申请日：2003-06-23

    申请人： David Olsen ,  Malcolm MacCoss ,  Balkrishen Bhat ,  Anne Eldrup

    发明人： David Olsen ,  Malcolm MacCoss ,  Balkrishen Bhat ,  Anne Eldrup

    IPC分类号： A61K31/7076 ,  C07H19/16 ,  C07H19/22

    CPC分类号： C07H19/22 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20

    摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

    摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。 还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。