利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

47 条记录 (耗时 0.034 秒)

    Butyrophenone derivatives
    3.
    发明授权
    Butyrophenone derivatives 失效
    丁酰苯衍生物

    公开(公告)号：US4009173A

    公开(公告)日：1977-02-22

    申请号：US617730

    申请日：1975-09-29

    申请人： Kikuo Sasajima ,  Masaru Nakao ,  Isamu Maruyama ,  Keiichi Ono ,  Shigenari Katayama ,  Shigeho Inaba ,  Hisao Yamamoto

    发明人： Kikuo Sasajima ,  Masaru Nakao ,  Isamu Maruyama ,  Keiichi Ono ,  Shigenari Katayama ,  Shigeho Inaba ,  Hisao Yamamoto

    IPC分类号： C07D211/64 ,  C07D403/04

    CPC分类号： C07D211/64

    摘要： Novel butyrophenone derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydroxyl group or ##STR2## (wherein R.sub.6 and R.sub.7 are each a hydrogen atom or a lower alkyl group or, when taken together with the adjacent nitrogen atom, may form a heterocyclic group), R.sub.2 represents an optionally substituted phenyl group or ##STR3## (wherein R.sub.8 and R.sub.9 are each a hydrogen atom or a lower alkyl group or, when taken together with the adjacent nitrogen atom, may form a heterocyclic group), R.sub.4 represents a hydrogen atom, a lower alkyl group or an optionally substituted phenyl group, R.sub.5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group, R.sub.10 represents a hydrogen atom or an acyl group represented by R.sub.3 CO- (wherein R.sub.3 is a hydrogen atom, a lower alkyl group or an optionally substituted phenyl group) and Z represents two hydrogen atoms or an oxygen atom, provided that when Z is an oxygen atom and R.sub.1 is ##STR4## R.sub.10 can not be a hydrogen atom, and their acid addition salts, which are useful as central and autonomic nervous system depressants.

    摘要翻译： 下式的新型丁基苯酚衍生物：其中R 1表示羟基或（其中R 6和R 7各自为氢原子或低级烷基，或者当与相邻的氮原子一起形成杂环时 基团），R 2表示任选取代的苯基或者其中R 8和R 9各自为氢原子或低级烷基，或者当与相邻的氮原子一起形成杂环基时，R 4表示 氢原子，低级烷基或任选取代的苯基，R 5表示氢原子，卤素原子，低级烷基，低级烷氧基或三氟甲基，R 10表示氢原子或R 3 CO 3表示的酰基 - （其中R 3是氢原子，低级烷基或任选取代的苯基），Z代表两个氢原子或氧原子，条件是当Z是氧原子且R 1不能是 氢原子， 和它们的酸加成盐，其可用作中枢神经系统抑制剂和自主神经系统抑制剂。

    Butyrophenone compounds
    7.
    发明授权
    Butyrophenone compounds 失效
    丁基苯酚化合物

    公开(公告)号：US4303663A

    公开(公告)日：1981-12-01

    申请号：US795145

    申请日：1977-05-09

    申请人： Kikuo Sasajima ,  Keiichi Ono ,  Masaru Nakao ,  Hisao Yamamoto

    发明人： Kikuo Sasajima ,  Keiichi Ono ,  Masaru Nakao ,  Hisao Yamamoto

    IPC分类号： C07D295/10 ,  A61K31/435 ,  A61K31/443 ,  A61K31/445 ,  A61K31/451 ,  A61P9/12 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/20 ,  A61P29/00 ,  C07D211/14 ,  C07D211/52 ,  C07D405/06 ,  C07D471/10

    CPC分类号： C07D211/52

    摘要： Butyrophenone compounds having excellent psychotropic activities represented by the formula: ##STR1## wherein R.sup.1 is a halogen atom, R.sup.2 is a lower alkyl group, and Z is a group of either one of the formulae: ##STR2## (wherein the dotted line indicates the optional presence of an additional single bond linkage, R.sup.3 is a hydrogen atom or a hydroxyl group but only when said additional single bond linkage is not present and R.sup.4 is a hydrogen atom or a phenyl or benzyl group optionally substituted with one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy and trifluoromethyl on the benzene ring (except monohalophenyl)), ##STR3## (wherein the dotted line indicates the optional presence of an additional single bond linkage, R.sup.5 is a hydrogen atom or a lower alkyl group and R.sup.6 and R.sup.7 are each a hydrogen atom, a halogen atom or a lower alkyl group), ##STR4## (wherein R.sup.8 is a hydrogen atom or a lower alkyl group and R.sup.9 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group), ##STR5## (wherein R.sup.10 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group), or ##STR6##

    Butyrophenone compounds as psychotropics
    8.
    发明授权
    Butyrophenone compounds as psychotropics 失效
    丁基酮化合物作为PSYCHOTROPICS

    公开(公告)号：US4039670A

    公开(公告)日：1977-08-02

    申请号：US568819

    申请日：1975-04-17

    申请人： Kikuo Sasajima ,  Keiichi Ono ,  Masaru Nakao ,  Hisao Yamamoto

    发明人： Kikuo Sasajima ,  Keiichi Ono ,  Masaru Nakao ,  Hisao Yamamoto

    IPC分类号： C07D295/10 ,  A61K31/435 ,  A61K31/443 ,  A61K31/445 ,  A61K31/451 ,  A61P9/12 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/20 ,  A61P29/00 ,  C07D211/14 ,  C07D211/52 ,  C07D405/06 ,  C07D471/10 ,  C07D487/10 ,  A01N9/22

    CPC分类号： C07D211/52

    摘要： Butyrophenone compounds having excellent psychotropic activities represented by the formula: ##STR1## wherein R.sup.1 is a halogen atom, R.sup.2 is a lower alkyl group, and Z is a group of either one of the formulae: ##STR2## (wherein the dotted line indicates the optional presence of an additional single bond linkage, R.sup.3 is a hydrogen atom or a hydroxyl group but only when said additional single bond linkage is not present and R.sup.4 is a hydrogen atom or a phenyl or benzyl group optionally substituted with one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkyoxy and trifluoromethyl on the benzene ring (except monohalophenyl)), ##STR3## (wherein the dotted line indicates the optional presence of an additional single bond linkage, R.sup.5 is a hydrogen atom or a lower alkyl group and R.sup.6 and R.sup.7 are each a hydrogen atom, a halogen atom or a lower alkyl group), ##STR4## (wherein R.sup.8 is a hydrogen atom or a lower alkyl group and R.sup.9 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group), ##STR5## (wherein R.sup.10 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group), or ##STR6##

    摘要翻译： 其中R1为卤原子，R2为低级烷基，Z为下列任何一个基团的基团：其中虚线表示的具有极好的精神活性的丁基苯酚化合物由下式表示： 线表示任选地存在另外的单键键，R3是氢原子或羟基，但仅在所述另外的单键键不存在且R4是氢原子或任选被一个或两个取代基取代的苯基或苄基时 取代基选自苯环上的卤素，低级烷基，低级烷氧基和三氟甲基（单卤代苯基除外）），其中虚线表示任选地存在另外的单键键，R5是 氢原子或低级烷基，R6和R7各自为氢原子，卤素原子或低级烷基），其中R8为氢原子或低级烷基，R9为 氢原子，卤素 原子，低级烷基或低级烷氧基），其中R 10为氢原子，卤素原子，低级烷基，低级烷氧基或三氟甲基。 （5）