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公开(公告)号：US06649657B2
公开(公告)日：2003-11-18
申请号：US10256985
申请日：2002-09-26
IPC分类号： A61K31235
CPC分类号： C07D207/263 , A61K45/06 , C07C235/34 , C07C311/04 , C07C311/06 , C07C323/49 , C07C2601/14 , C07C2602/08 , C07D209/14 , C07D213/42 , C07D215/18 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D271/12 , C07D277/28 , C07D277/56 , C07D307/24 , C07D307/52 , C07D307/68 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/24 , C07D333/34 , C07D333/38 , C07D409/12
摘要： Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.
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公开(公告)号：US06492412B2
公开(公告)日：2002-12-10
申请号：US09897824
申请日：2001-06-29
IPC分类号： A61K3140
CPC分类号： C07D207/263 , A61K45/06 , C07C235/34 , C07C311/04 , C07C311/06 , C07C323/49 , C07C2601/14 , C07C2602/08 , C07D209/14 , C07D213/42 , C07D215/18 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D271/12 , C07D277/28 , C07D277/56 , C07D307/24 , C07D307/52 , C07D307/68 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/24 , C07D333/34 , C07D333/38 , C07D409/12
摘要： Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.
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3.发明授权Prevention and treatment of skeletal disorder with EP2 receptor subtype selective prostaglandin E2 agonists 失效用EP2受体亚型选择性前列腺素E2激动剂预防和治疗骨骼疾病公开(公告)号：US06426359B1
公开(公告)日：2002-07-30
申请号：US09331078
申请日：1999-06-11
IPC分类号： A61K3141
CPC分类号： A61K31/195 , A61K31/00 , A61K31/18 , A61K31/192 , A61K31/197 , A61K31/20 , A61K31/381 , A61K31/41
摘要： This invention relates to the use of EP2 receptor subtype selective prostaglandin E2 agonists to augment bone mass including the prevention and treatment of skeletal disorders in mammals, including humans.
摘要翻译： 本发明涉及EP2受体亚型选择性前列腺素E2激动剂用于增加骨量的用途，包括预防和治疗哺乳动物（包括人）中的骨骼疾病。
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公开(公告)号：US06998423B2
公开(公告)日：2006-02-14
申请号：US10652188
申请日：2003-08-29
IPC分类号： A61K31/18 , A61K31/38 , C07C303/00 , C07D333/12
CPC分类号： C07D207/263 , A61K45/06 , C07C235/34 , C07C311/04 , C07C311/06 , C07C323/49 , C07C2601/14 , C07C2602/08 , C07D209/14 , C07D213/42 , C07D215/18 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D271/12 , C07D277/28 , C07D277/56 , C07D307/24 , C07D307/52 , C07D307/68 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/24 , C07D333/34 , C07D333/38 , C07D409/12
摘要： Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.
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5.发明授权Prevention of loss and restoration of bone mass by certain prostaglandin agonists 失效预防某些前列腺素激动剂损失和恢复骨量公开(公告)号：US06288120B1
公开(公告)日：2001-09-11
申请号：US09331081
申请日：1999-06-11
IPC分类号： A61K3116
CPC分类号： C07D207/263 , A61K45/06 , C07C235/34 , C07C311/04 , C07C311/06 , C07C323/49 , C07C2601/14 , C07C2602/08 , C07D209/14 , C07D213/42 , C07D215/18 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D271/12 , C07D277/28 , C07D277/56 , C07D307/24 , C07D307/52 , C07D307/68 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/24 , C07D333/34 , C07D333/38 , C07D409/12
摘要： Prostaglandin agonists of formula (I), in which, for example, A is a sulphonyl or acyl group, B is N or CH, M contains a ring and K and Q are linking groups, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits useful for the treatment of bone disorders including osteoporosis.
摘要翻译： 式（I）的前列腺素激动剂，其中例如A是磺酰基或酰基，B是N或CH，M包含环，K和Q是连接基团，使用这种前列腺素激动剂的方法，含有 这种前列腺素激动剂和用于治疗包括骨质疏松症在内的骨疾病的试剂盒。
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