公开(公告)号：US20100243485A1

公开(公告)日：2010-09-30

申请号：US12730391

申请日：2010-03-24

申请人： Kimihiko SATO ,  Kinya Nihei ,  Makoto Michiaki

发明人： Kimihiko SATO ,  Kinya Nihei ,  Makoto Michiaki

IPC分类号： A61B19/02

CPC分类号： A61C8/0087

摘要： To minimize titanium materials and accurately and easily fix a dental implant fixture, a housing container includes a glass housing main body, a resin cap, and a resin implant fixture holding member, the cap includes a press part at an inner surface, the implant fixture holding member fits into the bottom side of the housing main body, the implant fixture holding member has, at an upper surface side, three or more groove parts formed radially from a center to an end side, and titanium plate-like guide parts which include, at the center side, projected portions slightly projecting from the upper surface, and include, at the radial end side, erected portions extending up to at least equal to or more than ⅓ of a height from a tip of the dental implant fixture to erect around an outer peripheral surface of the dental implant fixture are inserted in the groove parts.

摘要翻译： 为了最小化钛材料并且准确且容易地固定牙种植体固定装置，容纳容器包括玻璃外壳主体，树脂盖和树脂植入物固定构件，所述盖在内表面具有加压部，植入物夹具 保持构件配合到壳体主体的底侧，植入物固定构件在上表面侧具有从中心到端部侧径向形成的三个以上的槽部，以及钛板状的引导部， 在中心侧，从上表面略微突出的突出部分，并且在径向端侧包括直立至少等于或大于牙科植入物固定器的尖端的高度的1/3的直立部分直立 围绕牙种植体固定装置的外周表面插入槽部分。

公开(公告)号：US20130116430A1

公开(公告)日：2013-05-09

申请号：US13730000

申请日：2012-12-28

申请人： Hideyasu FUJIWARA ,  Kimihiko SATO ,  Shinsuke MIZUMOTO ,  Yuichiro SATO ,  Hideki KURIHARA ,  Yohei KUBO ,  Hiyoku NAKATA ,  Yasutaka BABA ,  Takashi TAMURA ,  Hidenobu KUNIYOSHI ,  Shinji HAGIWARA ,  Mari YAMAMOTO

发明人： Hideyasu FUJIWARA ,  Kimihiko SATO ,  Shinsuke MIZUMOTO ,  Yuichiro SATO ,  Hideki KURIHARA ,  Yohei KUBO ,  Hiyoku NAKATA ,  Yasutaka BABA ,  Takashi TAMURA ,  Hidenobu KUNIYOSHI ,  Shinji HAGIWARA ,  Mari YAMAMOTO

IPC分类号： C07D401/12 ,  C07D401/04 ,  C07D213/82 ,  C07D513/04 ,  C07D413/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D401/14 ,  C07D471/04

CPC分类号： C07D401/12 ,  C07D213/82 ,  C07D215/40 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/107 ,  C07D498/04 ,  C07D513/04

摘要： An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

摘要翻译： 本发明的目的是提供具有优异的Syk抑制活性的化合物和药物组合物。 本发明提供下述式（I）表示的烟酰胺衍生物（其中，R1表示卤素原子，R2表示C1-12烷基，C2-12烯基，C2-12炔基，C3-8 环烷基，芳基，芳基-C 1-6烷基或杂环基，各自任选具有至少一个取代基; R 3表示各自任选具有至少一个取代基的芳基或杂环基;以及R 4和R 5各自 独立地表示氢原子; R2和R4可以形成任选具有至少一个取代基的环状氨基以及与它们结合的氮原子）或其盐，以及用于治疗Syk- 其包含烟酰胺衍生物或其盐。

公开(公告)号：US20090029050A1

公开(公告)日：2009-01-29

申请号：US12180889

申请日：2008-07-28

申请人： Kimihiko SATO ,  Yoshihiko Fujie ,  Shinichi Ichikawa ,  Takashi Hoshimiya ,  Naotsugu Muro

发明人： Kimihiko SATO ,  Yoshihiko Fujie ,  Shinichi Ichikawa ,  Takashi Hoshimiya ,  Naotsugu Muro

IPC分类号： B41M5/40 ,  B05D5/00 ,  C07D231/08

CPC分类号： B41M5/385 ,  B41M5/3854 ,  B41M2205/02 ,  C07D231/36 ,  C07D231/52

摘要： A heat-sensitive transfer recording ink sheet, containing a base material sheet and a dye-providing layer formed, wherein at least one kind of yellow dye contained in the dye-providing layer is an arylidenepyrazolone dye represented by formula (1): wherein X represents a substituted or unsubstituted alkoxy group having 1 to 6 carbon atoms; Y represents a halogen atom; R1 represents a substituted or unsubstituted aryl group having 6 to 10 carbon atoms; R2, R5 and R6 each represent a hydrogen atom, an unsubstituted alkyl group having 1 to 4 carbon atoms, an unsubstituted alkoxy group having 1 to 4 carbon atoms, or a halogen atom; and R3 and R4 each represent a substituted or unsubstituted alkyl group having 1 to 5 carbon atoms, or an allyl group.

摘要翻译： 一种含有形成的基材片和染料提供层的热敏转印记录油墨片，其中染料提供层中所含的至少一种黄色染料是由式（1）表示的亚芳基吡唑酮染料：其中X 表示取代或未取代的碳原子数1〜6的烷氧基。 Y表示卤原子; R1表示取代或未取代的碳原子数为6〜10的芳基， R 2，R 5和R 6各自表示氢原子，碳原子数1〜4的未取代烷基，碳原子数1〜4的未取代烷氧基或卤原子。 R 3和R 4各自表示取代或未取代的碳原子数1〜5的烷基或烯丙基。