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公开(公告)号：US07855056B2
公开(公告)日：2010-12-21
申请号：US10548688
申请日：2004-03-09
IPC分类号： G01N33/53
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。
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2.发明申请Oculospanin as a tumor specific antigen and methods and compositions utilizing same 审中-公开Oculospanin作为肿瘤特异性抗原以及利用其的方法和组合物公开(公告)号：US20070025996A1
公开(公告)日：2007-02-01
申请号：US11345651
申请日：2006-01-31
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30 , C40B40/10 , C40B30/06
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有特异性抗体的药物组合物来检测癌症的方法
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公开(公告)号：US20070166312A1
公开(公告)日：2007-07-19
申请号：US10548688
申请日：2004-03-09
IPC分类号： A61K39/395 , C07K16/30 , C12Q1/68 , G01N33/574
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。
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公开(公告)号：US20060127405A1
公开(公告)日：2006-06-15
申请号：US11223812
申请日：2005-09-09
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。
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公开(公告)号：US07741447B2
公开(公告)日：2010-06-22
申请号：US11872479
申请日：2007-10-15
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
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公开(公告)号：US20080146785A1
公开(公告)日：2008-06-19
申请号：US11872479
申请日：2007-10-15
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。
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公开(公告)号：US07361340B2
公开(公告)日：2008-04-22
申请号：US11223812
申请日：2005-09-09
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。
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公开(公告)号：US20060265765A1
公开(公告)日：2006-11-23
申请号：US11134165
申请日：2005-05-19
IPC分类号： A01K67/027 , C12N5/06 , A61K48/00
CPC分类号： C12N15/1135 , C07K14/82 , C12N2310/14
摘要： A method of producing cancer cells using an oncogene, a method of detecting cancer using the cancer cell, a method of screening compounds having cancer therapeutic and/or preventive effects and a cancer therapeutic and/or preventive pharmaceutical composition. There could be provided a method of detecting cancer using the expression of HOXB13 as an indicator wherein HOXB13 gene is excessively expressed in a cell, and a cell line in which cell growth ability is changed is selected; a method of screening compounds having novel cancer therapeutic and/or preventive effects by using OXB13; a pharmaceutical composition; and a method of treating cancer using said pharmaceutical composition.
摘要翻译： 使用癌基因产生癌细胞的方法，使用癌细胞检测癌症的方法，筛选具有癌症治疗和/或预防作用的化合物的方法以及癌症治疗和/或预防药物组合物。 可以提供使用HOXB13的表达作为指示剂检测癌症的方法，其中HOXB13基因在细胞中过度表达，并且选择其中细胞生长能力改变的细胞系; 通过使用OXB13筛选具有新型癌症治疗和/或预防效果的化合物的方法; 药物组合物; 以及使用所述药物组合物治疗癌症的方法。
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公开(公告)号：US09371395B2
公开(公告)日：2016-06-21
申请号：US13455021
申请日：2012-04-24
申请人： Shu Takahashi , Tatsuji Matsuoka , Kenji Murakami , Takeshi Takizawa , Kenji Hirotani , Atsushi Urano , Keisuke Fukuchi , Mitsuhiro Yazawa
发明人： Shu Takahashi , Tatsuji Matsuoka , Kenji Murakami , Takeshi Takizawa , Kenji Hirotani , Atsushi Urano , Keisuke Fukuchi , Mitsuhiro Yazawa
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/42 , C07K2317/24 , C07K2317/40 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or the functional fragment, methods for making the antibody or the functional fragment, methods for treating a tumor using the antibody or the functional fragment, and polynucleotides encoding the antibody or the functional fragment.
摘要翻译： 显示与B7-H3（抗体的功能片段）结合的抗肿瘤活性的抗体，包含抗体或功能片段的药物组合物，制备抗体或功能片段的方法，使用抗体治疗肿瘤的方法或 功能片段和编码抗体或功能片段的多核苷酸。
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公开(公告)号：US20130078234A1
公开(公告)日：2013-03-28
申请号：US13455021
申请日：2012-04-24
申请人： Shu Takahashi , Tatsuji Matsuoka , Kenji Murakami , Takeshi Takizawa , Kenji Hirotani , Atsushi Urano , Keisuke Fukuchi , Mitsuhiro Yazawa
发明人： Shu Takahashi , Tatsuji Matsuoka , Kenji Murakami , Takeshi Takizawa , Kenji Hirotani , Atsushi Urano , Keisuke Fukuchi , Mitsuhiro Yazawa
IPC分类号： C07K16/42
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/42 , C07K2317/24 , C07K2317/40 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or the functional fragment, methods for making the antibody or the functional fragment, methods for treating a tumor using the antibody or the functional fragment, and polynucleotides encoding the antibody or the functional fragment.
摘要翻译： 显示与B7-H3（抗体的功能片段）结合的抗肿瘤活性的抗体，包含抗体或功能片段的药物组合物，制备抗体或功能片段的方法，使用抗体治疗肿瘤的方法或 功能片段和编码抗体或功能片段的多核苷酸。
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