-
公开(公告)号：US20060127405A1
公开(公告)日：2006-06-15
申请号：US11223812
申请日：2005-09-09
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。
-
公开(公告)号：US07741447B2
公开(公告)日：2010-06-22
申请号：US11872479
申请日：2007-10-15
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
-
公开(公告)号：US20080146785A1
公开(公告)日：2008-06-19
申请号：US11872479
申请日：2007-10-15
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。
-
公开(公告)号：US07361340B2
公开(公告)日：2008-04-22
申请号：US11223812
申请日：2005-09-09
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。
-
公开(公告)号：US07855056B2
公开(公告)日：2010-12-21
申请号：US10548688
申请日：2004-03-09
IPC分类号： G01N33/53
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。
-
公开(公告)号：US20070166312A1
公开(公告)日：2007-07-19
申请号：US10548688
申请日：2004-03-09
IPC分类号： A61K39/395 , C07K16/30 , C12Q1/68 , G01N33/574
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有能够特异性识别人oculospanin并对癌细胞具有细胞毒性活性的抗体的药物组合物来检测癌症的方法。
-
7.发明申请Oculospanin as a tumor specific antigen and methods and compositions utilizing same 审中-公开Oculospanin作为肿瘤特异性抗原以及利用其的方法和组合物公开(公告)号：US20070025996A1
公开(公告)日：2007-02-01
申请号：US11345651
申请日：2006-01-31
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30 , C40B40/10 , C40B30/06
CPC分类号： C07K16/30 , C07K2317/732 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically
摘要翻译： 本发明涉及通过使用癌基因检测癌症的方法，筛选用于治疗和/或预防癌症的活性化合物的方法和用于治疗和/或预防癌症的药物组合物。 更具体地，本发明提供了一种基于人oculospanin基因作为标记物的表达和含有特异性抗体的药物组合物来检测癌症的方法
-
公开(公告)号：US20060265765A1
公开(公告)日：2006-11-23
申请号：US11134165
申请日：2005-05-19
IPC分类号： A01K67/027 , C12N5/06 , A61K48/00
CPC分类号： C12N15/1135 , C07K14/82 , C12N2310/14
摘要： A method of producing cancer cells using an oncogene, a method of detecting cancer using the cancer cell, a method of screening compounds having cancer therapeutic and/or preventive effects and a cancer therapeutic and/or preventive pharmaceutical composition. There could be provided a method of detecting cancer using the expression of HOXB13 as an indicator wherein HOXB13 gene is excessively expressed in a cell, and a cell line in which cell growth ability is changed is selected; a method of screening compounds having novel cancer therapeutic and/or preventive effects by using OXB13; a pharmaceutical composition; and a method of treating cancer using said pharmaceutical composition.
摘要翻译： 使用癌基因产生癌细胞的方法，使用癌细胞检测癌症的方法，筛选具有癌症治疗和/或预防作用的化合物的方法以及癌症治疗和/或预防药物组合物。 可以提供使用HOXB13的表达作为指示剂检测癌症的方法，其中HOXB13基因在细胞中过度表达，并且选择其中细胞生长能力改变的细胞系; 通过使用OXB13筛选具有新型癌症治疗和/或预防效果的化合物的方法; 药物组合物; 以及使用所述药物组合物治疗癌症的方法。
-
公开(公告)号：US09403909B2
公开(公告)日：2016-08-02
申请号：US13206736
申请日：2011-08-10
申请人： Reimi Kawaida , Toshiaki Ohtsuka , Toshinori Agatsuma , Philip Rodley , Sandra Miller , Ulrike Schubert
发明人： Reimi Kawaida , Toshiaki Ohtsuka , Toshinori Agatsuma , Philip Rodley , Sandra Miller , Ulrike Schubert
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2863 , A61K39/39558 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/565 , G01N2333/9121
摘要： The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for MST1R, which plays an integral role in various disorders or conditions, such as cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the disclosure also can be used in the diagnostics field, as well as for further investigating the role of MST1R in the progression of disorders associated with tumors. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译： 本公开提供了重组抗原结合区和包含对MST1R特异性的这种抗原结合区的功能片段，其在各种疾病或病症例如癌症中起积体作用。 因此，这些抗体可用于治疗这些和其他病症和病症。 本公开的抗体也可用于诊断领域，以及用于进一步研究MST1R在与肿瘤相关的疾病进展中的作用。 本公开还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。
-
公开(公告)号：US08449882B2
公开(公告)日：2013-05-28
申请号：US12713041
申请日：2010-02-25
申请人： Jun Hasegawa , Toshiaki Ohtsuka , Atsushi Urano , Junko Yamaguchi , Toshinori Agatsuma , Kaori Nakahara , Takeshi Takizawa
发明人： Jun Hasegawa , Toshiaki Ohtsuka , Atsushi Urano , Junko Yamaguchi , Toshinori Agatsuma , Kaori Nakahara , Takeshi Takizawa
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： Problem to Be SolvedIt is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc.SolutionThe present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.
摘要翻译： 要解决的问题旨在提供具有抑制细胞恶性转化和/或肿瘤细胞生长等的活性的抗体。溶液本发明提供一种抗体，其识别由杂交瘤SH348-1产生的抗体识别的表位 （FERM BP-10836）或杂交瘤SH357-1（FERM BP-10837），由杂交瘤SH348-1或杂交瘤SH357-1产生的抗体，通过将由杂交瘤SH348-1产生的抗体人源化而获得的抗体或 杂交瘤SH357-1是包含抗体作为活性成分的药剂等
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.032 秒)
